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- W2094095902 abstract "Purpose of review The thiazolidinediones are agonists for peroxisome proliferator-activated receptor-γ, and promote insulin sensitization and improve dyslipidemia in patients with type II diabetes mellitus. Peroxisome proliferator-activated receptor-γ transduces its actions by binding to common consensus response elements called peroxisome proliferator-activated receptor-response elements, thus modifying expression of numerous genes. Peroxisome proliferator-activated receptor-γ is widely expressed, including in macrophages and vascular smooth muscle cells. I will review recent novel insights into peroxisome proliferator-activated receptor-γ agonist actions. Recent findings The thiazolidinediones have beneficial effects in humans with type II diabetes related in part to improvement of dysmetabolic syndrome, and also have beneficial effects on progressive renal damage in animal models of diabetic nephropathy and in models with severe hyperlipidemia. Peroxisome proliferator-activated receptor-γ agonists also have direct benefits on progressive renal injury independent of altering the dysmetabolic profile. Summary We will review selected evidence of actions of peroxisome proliferator-activated receptor-γ agonists beyond metabolism, focusing on experimental work, and examine interactions with other key profibrotic mediators, including transforming growth factor-β and the renin–angiotensin system." @default.
- W2094095902 created "2016-06-24" @default.
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- W2094095902 date "2008-05-01" @default.
- W2094095902 modified "2023-09-26" @default.
- W2094095902 title "Potential for peroxisome proliferator-activated receptor-?? agonists in progression: beyond metabolism" @default.
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- W2094095902 doi "https://doi.org/10.1097/mnh.0b013e3282f9b1c0" @default.
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