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• W2094103113 abstract "RATIONALE: According to current treatment guidelines, the reduction of rescue medication use is one of the goals of asthma therapy. We investigated the effect of mometasone furoate (MF), an inhaled corticosteroid recently approved for the treatment of asthma in children 4 yrs and older, on rescue medication use.METHODS: The efficacy of MF delivered via a dry powder inhaler (DPI) was investigated in a randomized, placebo-controlled, double-blind, 12-week study in children 4-11 years of age with mild to moderate persistent asthma (results for the primary variable have been presented elsewhere). Patients received MF-DPI 100 μg once-daily in the evening (QD PM), the approved pediatric dose, 100 μg twice-daily (BID), or placebo. The effect of treatment on rescue medication use was assessed using analysis of variance on daily data from patient recorded diaries.RESULTS: A total of 296 children were randomized to therapy (99 to 100 μg QD PM; 98 to 100 μg BID; 99 to placebo). Baseline albuterol use was low (1.3 puffs/d) in all treatment groups. Patients in the MF-DPI QD PM and BID groups reported mean endpoint reductions of 19.5% and 13.4%, respectively, while patients on placebo experienced a mean increase of 22.4% (P ≤ 0.006). Analysis of weekly data revealed clear patterns of albuterol use reductions across the 12 weeks in both MF-DPI groups, but not in the placebo group.CONCLUSIONS: MF-DPI 100 μg administered either once daily in the evening or twice daily significantly reduced the need for rescue medication compared to placebo in children with mild to moderate persistent asthma. RATIONALE: According to current treatment guidelines, the reduction of rescue medication use is one of the goals of asthma therapy. We investigated the effect of mometasone furoate (MF), an inhaled corticosteroid recently approved for the treatment of asthma in children 4 yrs and older, on rescue medication use. METHODS: The efficacy of MF delivered via a dry powder inhaler (DPI) was investigated in a randomized, placebo-controlled, double-blind, 12-week study in children 4-11 years of age with mild to moderate persistent asthma (results for the primary variable have been presented elsewhere). Patients received MF-DPI 100 μg once-daily in the evening (QD PM), the approved pediatric dose, 100 μg twice-daily (BID), or placebo. The effect of treatment on rescue medication use was assessed using analysis of variance on daily data from patient recorded diaries. RESULTS: A total of 296 children were randomized to therapy (99 to 100 μg QD PM; 98 to 100 μg BID; 99 to placebo). Baseline albuterol use was low (1.3 puffs/d) in all treatment groups. Patients in the MF-DPI QD PM and BID groups reported mean endpoint reductions of 19.5% and 13.4%, respectively, while patients on placebo experienced a mean increase of 22.4% (P ≤ 0.006). Analysis of weekly data revealed clear patterns of albuterol use reductions across the 12 weeks in both MF-DPI groups, but not in the placebo group. CONCLUSIONS: MF-DPI 100 μg administered either once daily in the evening or twice daily significantly reduced the need for rescue medication compared to placebo in children with mild to moderate persistent asthma." @default.
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• W2094103113 date "2009-02-01" @default.
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• W2094103113 title "Effect of Inhaled Mometasone Furoate on the Use of Rescue Medication in Children Aged 4-11 Years With Mild to Moderate Persistent Asthma" @default.
• W2094103113 doi "https://doi.org/10.1016/j.jaci.2008.12.037" @default.
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