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- W2094107369 endingPage "2022" @default.
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- W2094107369 abstract "We examine features of intracellular networks that make errors less probable and beneficial responses more probable. In a false negative (F - ) error, a network does not respond to input. A network is reliable if it operates with a low probability of a F - error. Features that promote reliability include fewer reactions in sequence, more alternative pathways, no side reactions and negative feedback. In a false positive (F + ) error, a network produces output without input. Here, a network is specific if it has a low probability of a F + error. Conjunctions of signals within or between pathways can improve specificity through sigmoid steady-state response curves, kinetic proofreading and checkpoints. Both reliability and specificity are important in networks that regulate the fate of a cell and in networks with hubs or modules, and this includes scale-free networks. Some networks discriminate among several inputs by responding to each input through a different combination of pathways." @default.
- W2094107369 created "2016-06-24" @default.
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- W2094107369 date "2003-04-20" @default.
- W2094107369 modified "2023-09-25" @default.
- W2094107369 title "HOW CELLS AVOID ERRORS IN METABOLIC AND SIGNALING NETWORKS" @default.
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- W2094107369 doi "https://doi.org/10.1142/s0217979203018028" @default.
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