Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094114098> ?p ?o ?g. }
- W2094114098 endingPage "E747" @default.
- W2094114098 startingPage "E740" @default.
- W2094114098 abstract "Acute ethanol lowers blood pressure (BP) and cardiac output in proestrus and after chronic estrogen (E 2 ) replacement in ovariectomized (OVX) female rats. However, whether rapid nongenomic effects of estrogen mediate these hemodynamic effects of ethanol remains unanswered. To test this hypothesis, we investigated the effect of ethanol (0.5 or 1.5 g/kg iv) on left ventricular (LV) function and oxidative markers in OVX rats pretreated 30 min earlier with 1 μg/kg E 2 (OVXE 2 ) or vehicle (OVX) and in proestrus sham-operated (SO) rats. In SO rats, ethanol caused significant and dose-related reductions in BP, rate of rise in LV pressure (LV dP/d t max ), and LV developed pressure (LVDP). These effects of ethanol disappeared in OVX rats and were restored in OVXE 2 rats, suggesting rapid estrogen receptor signaling mediates the detrimental effects of ethanol on LV function. Ex vivo studies revealed that the estrogen-dependent myocardial dysfunction caused by ethanol was coupled with higher LV 1) generation of reactive oxygen species (ROS), 2) expression of malondialdehyde and 4-hydroxynonenal protein adducts, 3) phosphorylation of protein kinase B (Akt) and extracellular signal-regulated kinases (ERK1/2), and 4) catalase activity. ERK1/2 inhibition by PD-98059 (1 mg/kg iv) abrogated the myocardial dysfunction, hypotension, and the elevation in myocardial ROS generation caused by ethanol. We conclude that rapid estrogen receptor signaling is implicated in cellular events that lead to the generation of aldehyde protein adducts and Akt/ERK1/2 phosphorylation, which ultimately mediate the estrogen-dependent LV oxidative stress and dysfunction caused by ethanol in female rats." @default.
- W2094114098 created "2016-06-24" @default.
- W2094114098 creator A5045120949 @default.
- W2094114098 creator A5066348649 @default.
- W2094114098 date "2014-04-01" @default.
- W2094114098 modified "2023-09-25" @default.
- W2094114098 title "Nongenomic effects of estrogen mediate the dose-related myocardial oxidative stress and dysfunction caused by acute ethanol in female rats" @default.
- W2094114098 cites W1607885763 @default.
- W2094114098 cites W1843920924 @default.
- W2094114098 cites W19048478 @default.
- W2094114098 cites W1973508937 @default.
- W2094114098 cites W1974102018 @default.
- W2094114098 cites W1982181214 @default.
- W2094114098 cites W1986965597 @default.
- W2094114098 cites W1994716040 @default.
- W2094114098 cites W2003318565 @default.
- W2094114098 cites W2010835913 @default.
- W2094114098 cites W2011977714 @default.
- W2094114098 cites W2013781597 @default.
- W2094114098 cites W2022721973 @default.
- W2094114098 cites W2024258467 @default.
- W2094114098 cites W2042748218 @default.
- W2094114098 cites W2048866463 @default.
- W2094114098 cites W2057032896 @default.
- W2094114098 cites W2059266278 @default.
- W2094114098 cites W2060452153 @default.
- W2094114098 cites W2063150273 @default.
- W2094114098 cites W2063776151 @default.
- W2094114098 cites W2067164831 @default.
- W2094114098 cites W2069708529 @default.
- W2094114098 cites W2087206099 @default.
- W2094114098 cites W2087560515 @default.
- W2094114098 cites W2090054477 @default.
- W2094114098 cites W2094806874 @default.
- W2094114098 cites W2097209903 @default.
- W2094114098 cites W2114940674 @default.
- W2094114098 cites W2119909702 @default.
- W2094114098 cites W2120174052 @default.
- W2094114098 cites W2126787507 @default.
- W2094114098 cites W2134896063 @default.
- W2094114098 cites W2140336135 @default.
- W2094114098 cites W2140979949 @default.
- W2094114098 cites W2143166737 @default.
- W2094114098 cites W2151635729 @default.
- W2094114098 cites W2153156437 @default.
- W2094114098 cites W2167970711 @default.
- W2094114098 cites W2171478040 @default.
- W2094114098 cites W2324197323 @default.
- W2094114098 cites W2399534158 @default.
- W2094114098 cites W2414233691 @default.
- W2094114098 doi "https://doi.org/10.1152/ajpendo.00465.2013" @default.
- W2094114098 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3962612" @default.
- W2094114098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24368668" @default.
- W2094114098 hasPublicationYear "2014" @default.
- W2094114098 type Work @default.
- W2094114098 sameAs 2094114098 @default.
- W2094114098 citedByCount "22" @default.
- W2094114098 countsByYear W20941140982014 @default.
- W2094114098 countsByYear W20941140982015 @default.
- W2094114098 countsByYear W20941140982016 @default.
- W2094114098 countsByYear W20941140982017 @default.
- W2094114098 countsByYear W20941140982018 @default.
- W2094114098 countsByYear W20941140982019 @default.
- W2094114098 countsByYear W20941140982020 @default.
- W2094114098 countsByYear W20941140982021 @default.
- W2094114098 countsByYear W20941140982023 @default.
- W2094114098 crossrefType "journal-article" @default.
- W2094114098 hasAuthorship W2094114098A5045120949 @default.
- W2094114098 hasAuthorship W2094114098A5066348649 @default.
- W2094114098 hasBestOaLocation W20941140982 @default.
- W2094114098 hasConcept C11960822 @default.
- W2094114098 hasConcept C121608353 @default.
- W2094114098 hasConcept C126322002 @default.
- W2094114098 hasConcept C134018914 @default.
- W2094114098 hasConcept C185592680 @default.
- W2094114098 hasConcept C2776151105 @default.
- W2094114098 hasConcept C2777164284 @default.
- W2094114098 hasConcept C2778401633 @default.
- W2094114098 hasConcept C48349386 @default.
- W2094114098 hasConcept C530470458 @default.
- W2094114098 hasConcept C55493867 @default.
- W2094114098 hasConcept C71924100 @default.
- W2094114098 hasConcept C75217442 @default.
- W2094114098 hasConcept C8264082 @default.
- W2094114098 hasConcept C84606932 @default.
- W2094114098 hasConceptScore W2094114098C11960822 @default.
- W2094114098 hasConceptScore W2094114098C121608353 @default.
- W2094114098 hasConceptScore W2094114098C126322002 @default.
- W2094114098 hasConceptScore W2094114098C134018914 @default.
- W2094114098 hasConceptScore W2094114098C185592680 @default.
- W2094114098 hasConceptScore W2094114098C2776151105 @default.
- W2094114098 hasConceptScore W2094114098C2777164284 @default.
- W2094114098 hasConceptScore W2094114098C2778401633 @default.
- W2094114098 hasConceptScore W2094114098C48349386 @default.
- W2094114098 hasConceptScore W2094114098C530470458 @default.
- W2094114098 hasConceptScore W2094114098C55493867 @default.
- W2094114098 hasConceptScore W2094114098C71924100 @default.
- W2094114098 hasConceptScore W2094114098C75217442 @default.