FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094115680> ?p ?o ?g. }

• W2094115680 abstract "Interleukin-8 (IL-8) is a cytokine that plays an important role in tumor progression in a variety of cancer types; however, its regulation is not well understood in oral cancer cells. In the present study, we examined the expression and mechanism of IL-8 in which it is involved by treating immortalized (IHOK) and malignant human oral keratinocytes (HN12) cells with deferoxamine (DFO).IL-8 production was measured by an enzyme-linked immunoabsorbent assay and reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. Electrophoretic mobility shift assays was used to determine NF-kappaB binding activity. Phosphorylation and degradation of the I-kappaB were analyized by Western blot.IHOK cells incubated with DFO showed increased expression of IL-8 mRNA, as well as higher release of the IL-8 protein. The up-regulation of DFO-induced IL-8 expression was higher in IHOK cells than in HN12 cells and was concentration-dependent. DFO acted additively with IL-1beta to strongly up-regulate IL-8 in IHOK cells but not in HN12 cells. Accordingly, selective p38 and ERK1/2 inhibitors for both kinases abolished DFO-induced IL-8 expression in both IHOK and HN12 cells. Furthermore, DFO induced the degradation and phosphorylation of IkappaB, and activation of NF-kappaB. The IL-8 inducing effects of DFO were mediated by a nitric oxide donor (S-nitrosoglutathione), and by pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB, as well as by wortmannin, which inhibits the phosphatidylinositol 3-kinase-dependent activation of NAD(P)H oxidase.This results demonstrate that DFO-induced IL-8 acts via multiple signaling pathways in immortalized and malignant oral keratinocytes, and that the control of IL-8 may be an important target for immunotheraphy against human oral premalignant lesions." @default.
• W2094115680 created "2016-06-24" @default.
• W2094115680 creator A5000845909 @default.
• W2094115680 creator A5045470258 @default.
• W2094115680 creator A5053782281 @default.
• W2094115680 creator A5077437724 @default.
• W2094115680 creator A5078446358 @default.
• W2094115680 date "2007-09-13" @default.
• W2094115680 modified "2023-10-18" @default.
• W2094115680 title "Differential regulation of iron chelator-induced IL-8 synthesis via MAP kinase and NF-κB in immortalized and malignant oral keratinocytes" @default.
• W2094115680 cites W117293536 @default.
• W2094115680 cites W150428852 @default.
• W2094115680 cites W1510258932 @default.
• W2094115680 cites W1512629398 @default.
• W2094115680 cites W1541824835 @default.
• W2094115680 cites W1564880933 @default.
• W2094115680 cites W1575773639 @default.
• W2094115680 cites W1649488331 @default.
• W2094115680 cites W1766651653 @default.
• W2094115680 cites W1798720605 @default.
• W2094115680 cites W1825540737 @default.
• W2094115680 cites W1973050879 @default.
• W2094115680 cites W1978999739 @default.
• W2094115680 cites W1986074616 @default.
• W2094115680 cites W1997767982 @default.
• W2094115680 cites W1999613518 @default.
• W2094115680 cites W2010349134 @default.
• W2094115680 cites W201417514 @default.
• W2094115680 cites W2015834310 @default.
• W2094115680 cites W2020388734 @default.
• W2094115680 cites W2021757854 @default.
• W2094115680 cites W2021975445 @default.
• W2094115680 cites W2023853460 @default.
• W2094115680 cites W2026073973 @default.
• W2094115680 cites W2026948522 @default.
• W2094115680 cites W2027178659 @default.
• W2094115680 cites W202814004 @default.
• W2094115680 cites W2029790299 @default.
• W2094115680 cites W2032514624 @default.
• W2094115680 cites W2035888225 @default.
• W2094115680 cites W2036779260 @default.
• W2094115680 cites W2037647872 @default.
• W2094115680 cites W2048497033 @default.
• W2094115680 cites W2048600513 @default.
• W2094115680 cites W2052452616 @default.
• W2094115680 cites W2056880902 @default.
• W2094115680 cites W2065874620 @default.
• W2094115680 cites W2069736783 @default.
• W2094115680 cites W2073484057 @default.
• W2094115680 cites W2078319346 @default.
• W2094115680 cites W2079340418 @default.
• W2094115680 cites W2089872601 @default.
• W2094115680 cites W2093312816 @default.
• W2094115680 cites W2114269227 @default.
• W2094115680 cites W2114839218 @default.
• W2094115680 cites W2116161064 @default.
• W2094115680 cites W2124459218 @default.
• W2094115680 cites W2145512359 @default.
• W2094115680 cites W2159365184 @default.
• W2094115680 cites W216362062 @default.
• W2094115680 cites W2166059097 @default.
• W2094115680 cites W223983501 @default.
• W2094115680 cites W2413489495 @default.
• W2094115680 cites W2414256411 @default.
• W2094115680 cites W2419541310 @default.
• W2094115680 cites W4241216156 @default.
• W2094115680 doi "https://doi.org/10.1186/1471-2407-7-176" @default.
• W2094115680 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2078595" @default.
• W2094115680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17850672" @default.
• W2094115680 hasPublicationYear "2007" @default.
• W2094115680 type Work @default.
• W2094115680 sameAs 2094115680 @default.
• W2094115680 citedByCount "25" @default.
• W2094115680 countsByYear W20941156802012 @default.
• W2094115680 countsByYear W20941156802013 @default.
• W2094115680 countsByYear W20941156802014 @default.
• W2094115680 countsByYear W20941156802016 @default.
• W2094115680 countsByYear W20941156802018 @default.
• W2094115680 countsByYear W20941156802019 @default.
• W2094115680 countsByYear W20941156802020 @default.
• W2094115680 countsByYear W20941156802022 @default.
• W2094115680 countsByYear W20941156802023 @default.
• W2094115680 crossrefType "journal-article" @default.
• W2094115680 hasAuthorship W2094115680A5000845909 @default.
• W2094115680 hasAuthorship W2094115680A5045470258 @default.
• W2094115680 hasAuthorship W2094115680A5053782281 @default.
• W2094115680 hasAuthorship W2094115680A5077437724 @default.
• W2094115680 hasAuthorship W2094115680A5078446358 @default.
• W2094115680 hasBestOaLocation W20941156801 @default.
• W2094115680 hasConcept C104317684 @default.
• W2094115680 hasConcept C153911025 @default.
• W2094115680 hasConcept C184235292 @default.
• W2094115680 hasConcept C185592680 @default.
• W2094115680 hasConcept C203014093 @default.
• W2094115680 hasConcept C2776415932 @default.
• W2094115680 hasConcept C2776672577 @default.
• W2094115680 hasConcept C2777730290 @default.
• W2094115680 hasConcept C2778308172 @default.
• W2094115680 hasConcept C2778690821 @default.
• W2094115680 hasConcept C2780610907 @default.

• next