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- W2094122937 abstract "Overflow metabolism characterizes cells strains that are likely to produce inhibiting metabolites resulting from an excess of substrate feeding and a saturated respiratory capacity. The critical substrate level separating the two different metabolic pathways is generally not well defined. This paper proposes two non-model based extremum-seeking strategies preventing a too important accumulation of inhibiting metabolites in fed-batch cultures, by estimating the critical substrate level on the basis of 3 simple measurements related to the feeding, oxygen and carbon dioxide. A simple substrate controller based on Lyapunov stability arguments is then designed and tested in combination with the two extremum-seeking schemes." @default.
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- W2094122937 date "2009-01-01" @default.
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- W2094122937 title "Adaptive extremum-seeking control of fed-batch cultures of micro-organisms exhibiting overflow metabolism" @default.
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- W2094122937 doi "https://doi.org/10.3182/20090712-4-tr-2008.00024" @default.
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