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• W2094130116 abstract "<h2>Abstract</h2> This study was designed to establish the in vivo relationship between tenoxicam disposition and changes in plasma protein binding measured as an unbound fraction in plasma <i>(f_u).</i> Tenoxicam was administered as a bolus 5-mg/kg dose, and total plasma concentrations, plasma albumin percentage, and <i>f_u</i> were examined in five groups of rats (uremia or anephric states were experimentally induced in four groups to decrease plasma protein levels). Albumin levels were significantly decreased in all experimentally altered groups with respect to control animals (<i>p <</i> 0.01). A two-compartment population pharmacokinetic model that includes the effect of <i>f_u</i> on the kinetic parameters was proposed to describe tenoxicam plasma concentration profiles. Plasma clearance (CL) increased but not proportionally with <i>f_u.</i> Apparent volume of distribution of the central compartment <i>(v)</i> was linearly related to changes in <i>f_u</i>, and intercompartmental clearance was not affected by altered plasma protein binding. Expressing pharmacokinetic parameters as a function of <i>f_u</i> resulted in a three- and five-fold decrease in the variability associated with CL and <i>V,</i> respectively." @default.
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• W2094130116 date "1995-12-01" @default.
• W2094130116 modified "2023-09-27" @default.
• W2094130116 title "Tenoxicam Pharmacokinetics In Rats: A Population Model" @default.
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• W2094130116 doi "https://doi.org/10.1002/jps.2600841216" @default.
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