FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094134310> ?p ?o ?g. }

• W2094134310 endingPage "683" @default.
• W2094134310 startingPage "671" @default.
• W2094134310 abstract "The PLATO (Platelet Inhibition and Patient Outcomes) angiographic substudy sought to compare the efficacy of ticagrelor versus clopidogrel with respect to angiographic outcomes before and after PCI in the setting of acute coronary syndrome. Greater platelet inhibition has been associated with improved angiographic outcomes before and after percutaneous coronary intervention (PCI). Therefore, it was hypothesized that treatment with ticagrelor, which achieves more rapid, higher, and more consistent platelet inhibition, would be associated with improved angiographic outcomes when compared with those of clopidogrel treatment. The angiographic cohort consists of 2,616 patients drawn from the 18,624-patient PLATO trial. Clopidogrel naïve or pre-treated patients were randomized to 180 mg of ticagrelor or 300 mg of clopidogrel (75 mg for clopidogrel pre-treated patients). PCI patients were administered, as per treatment group: 1) an additional 90 mg of ticagrelor if >24 h following the initial loading dose; or 2) an optional further 300 mg of clopidogrel or placebo (total 600 mg) prior to PCI. The substudy primary endpoint was the incidence of post-PCI TIMI (Thrombolysis In Myocardial Infarction) myocardial perfusion grade 3 (TMPG 3) among patients who received a study drug prior to PCI. In total, 21.3% of patients were pretreated with clopidogrel prior to randomization. There was a short time interval between randomization and PCI (median: 0.68 [interquartile range (IQR): 0.30 to 2.21] h) among all patients. Post-PCI TMPG 3 was similar between the ticagrelor and clopidogrel groups (47.1% vs. 46.9%; p = 0.96). Likewise, the following pre-PCI outcomes were similar in the ticagrelor and clopidogrel groups, respectively: TMPG 3 (30.5% vs. 31.2%), TIMI flow grade 3 (37.1% vs. 39.3%), corrected TIMI frame count (median: 100 vs. 71 frames), TIMI thrombus grade 0 (24.1% vs. 27.6%), minimum lumen diameter (median: 0.3 [IQR: 0.0 to 0.6] vs. 0.3 [IQR: 0.0 to 0.6] mm) and percentage of diameter stenosis (median: 89 [IQR: 78 to 100] vs. 89 [IQR: 77 to 100]). Neither coronary flow nor myocardial perfusion, evaluated on coronary angiograms performed before or following PCI procedures within a few hours after the start of oral antiplatelet treatment in the setting of acute coronary syndromes, demonstrated a difference with ticagrelor versus clopidogrel. (A Comparison of Ticagrelor [AZD6140] and Clopidogrel in Patients With Acute Coronary Syndrome [PLATO]; NCT00391872)" @default.
• W2094134310 created "2016-06-24" @default.
• W2094134310 creator A5003831287 @default.
• W2094134310 creator A5004283497 @default.
• W2094134310 creator A5007026783 @default.
• W2094134310 creator A5012282245 @default.
• W2094134310 creator A5027138068 @default.
• W2094134310 creator A5027313461 @default.
• W2094134310 creator A5039450208 @default.
• W2094134310 creator A5047038776 @default.
• W2094134310 creator A5049262839 @default.
• W2094134310 creator A5049601452 @default.
• W2094134310 creator A5060370891 @default.
• W2094134310 creator A5063591215 @default.
• W2094134310 creator A5073596004 @default.
• W2094134310 creator A5075060290 @default.
• W2094134310 date "2013-07-01" @default.
• W2094134310 modified "2023-10-11" @default.
• W2094134310 title "Angiographic Outcomes in the PLATO Trial (Platelet Inhibition and Patient Outcomes)" @default.
• W2094134310 cites W1519150396 @default.
• W2094134310 cites W161671725 @default.
• W2094134310 cites W1970487416 @default.
• W2094134310 cites W1994268354 @default.
• W2094134310 cites W2002429810 @default.
• W2094134310 cites W2004940488 @default.
• W2094134310 cites W2007957848 @default.
• W2094134310 cites W2019628996 @default.
• W2094134310 cites W2025430764 @default.
• W2094134310 cites W2036024297 @default.
• W2094134310 cites W2037709494 @default.
• W2094134310 cites W2064667702 @default.
• W2094134310 cites W2082965061 @default.
• W2094134310 cites W2087165431 @default.
• W2094134310 cites W2087951913 @default.
• W2094134310 cites W2100118923 @default.
• W2094134310 cites W2112925618 @default.
• W2094134310 cites W2120828479 @default.
• W2094134310 cites W2140501627 @default.
• W2094134310 cites W2153447053 @default.
• W2094134310 cites W2161055506 @default.
• W2094134310 cites W2161872374 @default.
• W2094134310 cites W2163050713 @default.
• W2094134310 cites W2169284238 @default.
• W2094134310 cites W2170312517 @default.
• W2094134310 cites W2214579191 @default.
• W2094134310 cites W2221460676 @default.
• W2094134310 cites W4235858444 @default.
• W2094134310 cites W2126480769 @default.
• W2094134310 doi "https://doi.org/10.1016/j.jcin.2013.03.014" @default.
• W2094134310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23866179" @default.
• W2094134310 hasPublicationYear "2013" @default.
• W2094134310 type Work @default.
• W2094134310 sameAs 2094134310 @default.
• W2094134310 citedByCount "36" @default.
• W2094134310 countsByYear W20941343102013 @default.
• W2094134310 countsByYear W20941343102014 @default.
• W2094134310 countsByYear W20941343102015 @default.
• W2094134310 countsByYear W20941343102016 @default.
• W2094134310 countsByYear W20941343102017 @default.
• W2094134310 countsByYear W20941343102018 @default.
• W2094134310 countsByYear W20941343102019 @default.
• W2094134310 countsByYear W20941343102021 @default.
• W2094134310 countsByYear W20941343102022 @default.
• W2094134310 countsByYear W20941343102023 @default.
• W2094134310 crossrefType "journal-article" @default.
• W2094134310 hasAuthorship W2094134310A5003831287 @default.
• W2094134310 hasAuthorship W2094134310A5004283497 @default.
• W2094134310 hasAuthorship W2094134310A5007026783 @default.
• W2094134310 hasAuthorship W2094134310A5012282245 @default.
• W2094134310 hasAuthorship W2094134310A5027138068 @default.
• W2094134310 hasAuthorship W2094134310A5027313461 @default.
• W2094134310 hasAuthorship W2094134310A5039450208 @default.
• W2094134310 hasAuthorship W2094134310A5047038776 @default.
• W2094134310 hasAuthorship W2094134310A5049262839 @default.
• W2094134310 hasAuthorship W2094134310A5049601452 @default.
• W2094134310 hasAuthorship W2094134310A5060370891 @default.
• W2094134310 hasAuthorship W2094134310A5063591215 @default.
• W2094134310 hasAuthorship W2094134310A5073596004 @default.
• W2094134310 hasAuthorship W2094134310A5075060290 @default.
• W2094134310 hasConcept C119060515 @default.
• W2094134310 hasConcept C126322002 @default.
• W2094134310 hasConcept C164705383 @default.
• W2094134310 hasConcept C2777028646 @default.
• W2094134310 hasConcept C2777849778 @default.
• W2094134310 hasConcept C2777995511 @default.
• W2094134310 hasConcept C2780400711 @default.
• W2094134310 hasConcept C2780890252 @default.
• W2094134310 hasConcept C35294091 @default.
• W2094134310 hasConcept C45393284 @default.
• W2094134310 hasConcept C500558357 @default.
• W2094134310 hasConcept C71924100 @default.
• W2094134310 hasConceptScore W2094134310C119060515 @default.
• W2094134310 hasConceptScore W2094134310C126322002 @default.
• W2094134310 hasConceptScore W2094134310C164705383 @default.
• W2094134310 hasConceptScore W2094134310C2777028646 @default.
• W2094134310 hasConceptScore W2094134310C2777849778 @default.
• W2094134310 hasConceptScore W2094134310C2777995511 @default.
• W2094134310 hasConceptScore W2094134310C2780400711 @default.

• next