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• W2094149847 abstract "In their systematic review of blood brain barrier (BBB) uring ageing and microvascular disease, Drs Andrew Farrall nd Joanna Wardlaw summarized 31 publications on human, nd concluded BBB permeability increases with normal ageng (Farrall and Wardlaw, 2009). In the 31 publications, 8 used maging and 23 used biochemical techniques to assess BBB ermeability, in which 21 used albumin ratio of cerebrospinal uid (CSF)/plasma. I feel that Andrew Farrall and Joanna ardlaw have selected and analysed the data well, howver other interpretations have not been offered. Elevation f CSF/plasma albumin ratio has variously been interpreted s a decline in CSF secretion rate (Reiber, 1994; Silverberg t al., 2003) and/or increased permeability of brain barriers Kleine et al., 1993) as well as isolated blood–CSF barrier ysfunction (IBD) (Brettschneider et al., 2005). CSF is mostly secreted by choroid plexuses, which are ocated throughout four ventricles of the brain. In humans, SF volume is 80–150 ml and new CSF is formed at a rate f approximately 500 ml per day. With increasing age, in he absence of disease, changes have been demonstrated in he choroid plexus and associated CSF circulatory system Preston, 2001; Serot et al., 2003; Emerich et al., 2005). The ate of CSF production in healthy elderly people have been ound to be half that of their younger counterparts: the mean ate of CSF production is approximately 0.41 ml min−1 for oung healthy people and 0.19 ml min−1 for elderly healthy eople (May et al., 1990). Brain volumes start to decrease round 40 years of age with CSF volumes start to increase ccordingly (Matsumae et al., 1996). As such, CSF turn over s slower during ageing: CSF in elderly people with brain trophy is turned over only once a day but in young healthy" @default.
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• W2094149847 date "2011-07-01" @default.
• W2094149847 modified "2023-09-25" @default.
• W2094149847 title "Is it appropriate to use albumin CSF/plasma ratio to assess blood brain barrier permeability?" @default.
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• W2094149847 doi "https://doi.org/10.1016/j.neurobiolaging.2008.08.024" @default.
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