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• W2094158219 startingPage "6" @default.
• W2094158219 abstract "Transformation of testosterone and progesterone into synthetically challenging 14α-hydroxy derivatives was achieved by using fungal strain Mucor hiemalis. Prolonged incubation led to the formation of corresponding 6β/7α,14α-dihydroxy metabolites. The position and stereochemistry of newly introduced hydroxyl group was determined by detailed spectroscopic analyses. The time course experiment indicated that fungal strain initiated transformation by hydroxylation at 14α-position followed by at 6β- or 7α-positions. Studies using cell-free extracts suggest that the 14α-hydroxylase activity is NADPH dependent and belongs to the cytochrome P450 family." @default.
• W2094158219 created "2016-06-24" @default.
• W2094158219 creator A5031773512 @default.
• W2094158219 creator A5043899615 @default.
• W2094158219 creator A5058502576 @default.
• W2094158219 creator A5072020769 @default.
• W2094158219 date "2014-07-01" @default.
• W2094158219 modified "2023-09-26" @default.
• W2094158219 title "Mucor hiemalis mediated 14α-hydroxylation on steroids: In vivo and in vitro investigations of 14α-hydroxylase activity" @default.
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• W2094158219 doi "https://doi.org/10.1016/j.steroids.2014.04.002" @default.
• W2094158219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24747772" @default.
• W2094158219 hasPublicationYear "2014" @default.
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