Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094163014> ?p ?o ?g. }
- W2094163014 endingPage "123" @default.
- W2094163014 startingPage "114" @default.
- W2094163014 abstract "Insulin and leptin are hypothesized to be 'adiposity signals' for the long-term regulation of body weight by the brain. Accordingly, a change in the plasma levels of leptin or insulin indicates a state of altered energy homeostasis and adiposity, and the brain responds by adjusting food intake to restore adipose tissue mass to a regulated level. The candidate site for the brain's detection of leptin adiposity signaling is the hypothalamic arcuate nucleus, where leptin inhibits expression neuropeptide Y and increases expression of the pro-opiomelanocortin (POMC) precursor of alphaMSH. Insulin also inhibits arcuate nucleus expression of neuropeptide Y but its effects on other hypothalamic signaling systems are not known. Leptin-responsive neurons in the arcuate nucleus are hypothesized to project to the paraventricular nucleus and lateral hypothalamic area where they are proposed to influence the expression of peptides that regulate food intake. Future development of this model will incorporate brain pathways for integration of leptin and insulin adiposity signaling to the hypothalamus with meal-related signals that act in the caudal brainstem. Recent research showing that leptin and insulin enhance the satiety action of peripheral CCK, thereby causing meals to be terminated earlier and reducing cumulative food intake, suggests that hypothalamic pathways that are sensitive to leptin and insulin adiposity signals have anatomical connections with caudal brainstem neurons that respond to meal-related signals and regulate meal size. The recent findings that insulin alters the expression and function of neural transporters for dopamine and norepinephrine indicate that adiposity signals may influence food intake by acting on non-peptide neurotransmitter systems." @default.
- W2094163014 created "2016-06-24" @default.
- W2094163014 creator A5035450241 @default.
- W2094163014 creator A5046785493 @default.
- W2094163014 creator A5053926256 @default.
- W2094163014 creator A5065488328 @default.
- W2094163014 creator A5072056585 @default.
- W2094163014 creator A5072321501 @default.
- W2094163014 date "1999-11-01" @default.
- W2094163014 modified "2023-09-27" @default.
- W2094163014 title "Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight" @default.
- W2094163014 cites W1481893565 @default.
- W2094163014 cites W1486463812 @default.
- W2094163014 cites W1490643348 @default.
- W2094163014 cites W1499189927 @default.
- W2094163014 cites W1512875938 @default.
- W2094163014 cites W1627229807 @default.
- W2094163014 cites W1631449371 @default.
- W2094163014 cites W1639930240 @default.
- W2094163014 cites W1668039320 @default.
- W2094163014 cites W1906815697 @default.
- W2094163014 cites W1966464425 @default.
- W2094163014 cites W1968666103 @default.
- W2094163014 cites W1971974687 @default.
- W2094163014 cites W1972455073 @default.
- W2094163014 cites W1974760551 @default.
- W2094163014 cites W1976083063 @default.
- W2094163014 cites W1976459015 @default.
- W2094163014 cites W1977123850 @default.
- W2094163014 cites W1977769018 @default.
- W2094163014 cites W1978082185 @default.
- W2094163014 cites W1979860654 @default.
- W2094163014 cites W1980392808 @default.
- W2094163014 cites W1980710373 @default.
- W2094163014 cites W1981223547 @default.
- W2094163014 cites W1985528328 @default.
- W2094163014 cites W1992841732 @default.
- W2094163014 cites W1993137505 @default.
- W2094163014 cites W1993506310 @default.
- W2094163014 cites W1996634799 @default.
- W2094163014 cites W1996866169 @default.
- W2094163014 cites W2001660140 @default.
- W2094163014 cites W2001997802 @default.
- W2094163014 cites W2003590296 @default.
- W2094163014 cites W2004267191 @default.
- W2094163014 cites W2005262731 @default.
- W2094163014 cites W2007387523 @default.
- W2094163014 cites W2012953974 @default.
- W2094163014 cites W2014163208 @default.
- W2094163014 cites W2015260700 @default.
- W2094163014 cites W2016261339 @default.
- W2094163014 cites W2017155412 @default.
- W2094163014 cites W2020801856 @default.
- W2094163014 cites W2022908812 @default.
- W2094163014 cites W2023604436 @default.
- W2094163014 cites W2027180375 @default.
- W2094163014 cites W2027357022 @default.
- W2094163014 cites W2027740042 @default.
- W2094163014 cites W2027842060 @default.
- W2094163014 cites W2028654736 @default.
- W2094163014 cites W2032641816 @default.
- W2094163014 cites W2037001250 @default.
- W2094163014 cites W2040393764 @default.
- W2094163014 cites W2040965413 @default.
- W2094163014 cites W2041608072 @default.
- W2094163014 cites W2041677480 @default.
- W2094163014 cites W2041872947 @default.
- W2094163014 cites W2042505278 @default.
- W2094163014 cites W2043551756 @default.
- W2094163014 cites W2044153433 @default.
- W2094163014 cites W2045948521 @default.
- W2094163014 cites W2047578757 @default.
- W2094163014 cites W2047780911 @default.
- W2094163014 cites W2051138072 @default.
- W2094163014 cites W2053448608 @default.
- W2094163014 cites W2056463729 @default.
- W2094163014 cites W2059035261 @default.
- W2094163014 cites W2059768976 @default.
- W2094163014 cites W2061071379 @default.
- W2094163014 cites W2061128822 @default.
- W2094163014 cites W2061211669 @default.
- W2094163014 cites W2061240699 @default.
- W2094163014 cites W2064107055 @default.
- W2094163014 cites W2064342369 @default.
- W2094163014 cites W2065389660 @default.
- W2094163014 cites W2068555170 @default.
- W2094163014 cites W2079965579 @default.
- W2094163014 cites W2080205372 @default.
- W2094163014 cites W2080792301 @default.
- W2094163014 cites W2084234221 @default.
- W2094163014 cites W2085184474 @default.
- W2094163014 cites W2085858671 @default.
- W2094163014 cites W2087771814 @default.
- W2094163014 cites W2088777766 @default.
- W2094163014 cites W2089145764 @default.
- W2094163014 cites W2095566802 @default.
- W2094163014 cites W2099485290 @default.
- W2094163014 cites W2099542131 @default.