Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094166416> ?p ?o ?g. }
- W2094166416 endingPage "184" @default.
- W2094166416 startingPage "176" @default.
- W2094166416 abstract "Nitric oxide (NO) signaling pathways are important in both the maintenance of vascular homeostasis and disease progression. Overproduction of NO has been associated with ischemia/reperfusion (I/R) injury. Growing evidences suggest that NO preconditioning has cytoprotective effects against I/R injury. However, the mechanism with which NO mediates these effects remains to be elucidated. The purpose of this study was to examine the mechanism of how NO preconditioning inhibits subsequent NO-induced apoptosis in vascular smooth muscle cells (VSMC), specifically focusing on heme oxygenase-1 (HO-1). According to our data, sodium nitroprusside (SNP) increased HO-1 expression in a concentration dependent manner. Preconditioning with low concentration SNP (0.3 mM) inhibited subsequent high concentration SNP (1.5 mM)-induced apoptosis, and this effect was reversed by the HO-1 inhibitor SnPP. Low concentration SNP-mediated protection involved p38 kinase inactivation and increased Bcl-2 expression. Furthermore, mitochondrial membrane potential was concomitantly increased with decreased expressions of Bax, Apaf-1, and activity of caspase-3, which was reversed by SnPP treatment. Our results show that low concentration SNP preconditioning suppresses subsequent high concentration SNP-induced apoptosis by inhibiting p38 kinase and mitochondrial death pathway via HO-1-dependent mechanisms in VSMC." @default.
- W2094166416 created "2016-06-24" @default.
- W2094166416 creator A5017076611 @default.
- W2094166416 creator A5019857578 @default.
- W2094166416 creator A5026277569 @default.
- W2094166416 creator A5054692163 @default.
- W2094166416 creator A5075083918 @default.
- W2094166416 creator A5081241518 @default.
- W2094166416 creator A5090619031 @default.
- W2094166416 date "2006-12-01" @default.
- W2094166416 modified "2023-09-27" @default.
- W2094166416 title "Preconditioning with low concentration NO attenuates subsequent NO-induced apoptosis in vascular smooth muscle cells via HO-1-dependent mitochondrial death pathway" @default.
- W2094166416 cites W1500284214 @default.
- W2094166416 cites W1560571961 @default.
- W2094166416 cites W1564622409 @default.
- W2094166416 cites W1592891802 @default.
- W2094166416 cites W1664175075 @default.
- W2094166416 cites W1834041853 @default.
- W2094166416 cites W186823696 @default.
- W2094166416 cites W1945199177 @default.
- W2094166416 cites W1973081785 @default.
- W2094166416 cites W1973470186 @default.
- W2094166416 cites W1974980101 @default.
- W2094166416 cites W1975889968 @default.
- W2094166416 cites W1982669384 @default.
- W2094166416 cites W1985370516 @default.
- W2094166416 cites W1990792990 @default.
- W2094166416 cites W1990798856 @default.
- W2094166416 cites W1997507706 @default.
- W2094166416 cites W2024722417 @default.
- W2094166416 cites W2044615514 @default.
- W2094166416 cites W2048020333 @default.
- W2094166416 cites W2048635427 @default.
- W2094166416 cites W2054998714 @default.
- W2094166416 cites W2065016765 @default.
- W2094166416 cites W2065533511 @default.
- W2094166416 cites W2076708176 @default.
- W2094166416 cites W2077082072 @default.
- W2094166416 cites W2088968342 @default.
- W2094166416 cites W2093470973 @default.
- W2094166416 cites W2106922430 @default.
- W2094166416 cites W2108494929 @default.
- W2094166416 cites W2113226850 @default.
- W2094166416 cites W2113349789 @default.
- W2094166416 cites W2118440238 @default.
- W2094166416 cites W2128451405 @default.
- W2094166416 cites W2133309314 @default.
- W2094166416 cites W2134819997 @default.
- W2094166416 cites W2136391397 @default.
- W2094166416 cites W2139328513 @default.
- W2094166416 cites W2145530136 @default.
- W2094166416 cites W2149301933 @default.
- W2094166416 cites W2164763960 @default.
- W2094166416 cites W2181612539 @default.
- W2094166416 cites W2188229462 @default.
- W2094166416 cites W2313518958 @default.
- W2094166416 cites W4235776510 @default.
- W2094166416 doi "https://doi.org/10.1016/j.taap.2006.08.010" @default.
- W2094166416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17027882" @default.
- W2094166416 hasPublicationYear "2006" @default.
- W2094166416 type Work @default.
- W2094166416 sameAs 2094166416 @default.
- W2094166416 citedByCount "17" @default.
- W2094166416 countsByYear W20941664162015 @default.
- W2094166416 countsByYear W20941664162016 @default.
- W2094166416 countsByYear W20941664162017 @default.
- W2094166416 countsByYear W20941664162019 @default.
- W2094166416 countsByYear W20941664162020 @default.
- W2094166416 crossrefType "journal-article" @default.
- W2094166416 hasAuthorship W2094166416A5017076611 @default.
- W2094166416 hasAuthorship W2094166416A5019857578 @default.
- W2094166416 hasAuthorship W2094166416A5026277569 @default.
- W2094166416 hasAuthorship W2094166416A5054692163 @default.
- W2094166416 hasAuthorship W2094166416A5075083918 @default.
- W2094166416 hasAuthorship W2094166416A5081241518 @default.
- W2094166416 hasAuthorship W2094166416A5090619031 @default.
- W2094166416 hasConcept C134018914 @default.
- W2094166416 hasConcept C178790620 @default.
- W2094166416 hasConcept C184235292 @default.
- W2094166416 hasConcept C185592680 @default.
- W2094166416 hasConcept C190283241 @default.
- W2094166416 hasConcept C2779395532 @default.
- W2094166416 hasConcept C2779610285 @default.
- W2094166416 hasConcept C28859421 @default.
- W2094166416 hasConcept C2992686903 @default.
- W2094166416 hasConcept C48349386 @default.
- W2094166416 hasConcept C51551487 @default.
- W2094166416 hasConcept C519581460 @default.
- W2094166416 hasConcept C55493867 @default.
- W2094166416 hasConcept C62478195 @default.
- W2094166416 hasConcept C86803240 @default.
- W2094166416 hasConcept C95444343 @default.
- W2094166416 hasConcept C97029542 @default.
- W2094166416 hasConcept C98274493 @default.
- W2094166416 hasConceptScore W2094166416C134018914 @default.
- W2094166416 hasConceptScore W2094166416C178790620 @default.
- W2094166416 hasConceptScore W2094166416C184235292 @default.
- W2094166416 hasConceptScore W2094166416C185592680 @default.