FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094166501> ?p ?o ?g. }

• W2094166501 endingPage "368" @default.
• W2094166501 startingPage "358" @default.
• W2094166501 abstract "After birth, the intestinal mucosa undergoes a dramatic transition from a sterile protected site to an environmentally exposed and permanently colonized surface. The mechanisms that facilitate this transition are ill defined. Here, we demonstrate that microRNA-146a-mediated translational repression and proteolytic degradation of the essential Toll-like receptor (TLR) signaling molecule interleukin 1 receptor associated kinase 1 (IRAK1) is sufficient to induce intestinal epithelial innate immune tolerance and provide protection from bacteria-induced epithelial damage in neonates. Despite low IRAK1 protein levels, continuous TLR4- and IRAK1-dependent signal transduction induced by intraepithelial endotoxin persistence during the neonatal period maintains tolerance through sustained miR-146a expression. Strikingly, it additionally facilitates transcription of a distinct set of genes involved in cell survival, differentiation, and homeostasis. Thus, our results identify the underlying molecular mechanisms of intestinal epithelial innate immune tolerance during the neonatal period and characterize tolerance as an active condition involved in the establishment of intestinal mucosal homeostasis." @default.
• W2094166501 created "2016-06-24" @default.
• W2094166501 creator A5022571530 @default.
• W2094166501 creator A5023281192 @default.
• W2094166501 creator A5036467945 @default.
• W2094166501 creator A5039486913 @default.
• W2094166501 creator A5066957565 @default.
• W2094166501 creator A5083360417 @default.
• W2094166501 creator A5084471744 @default.
• W2094166501 date "2010-10-01" @default.
• W2094166501 modified "2023-10-17" @default.
• W2094166501 title "miR-146a Mediates Protective Innate Immune Tolerance in the Neonate Intestine" @default.
• W2094166501 cites W1489852543 @default.
• W2094166501 cites W1646013386 @default.
• W2094166501 cites W1661787331 @default.
• W2094166501 cites W1829670604 @default.
• W2094166501 cites W1974976948 @default.
• W2094166501 cites W2000121863 @default.
• W2094166501 cites W2007908049 @default.
• W2094166501 cites W2020960610 @default.
• W2094166501 cites W2024633528 @default.
• W2094166501 cites W2030605887 @default.
• W2094166501 cites W2035217892 @default.
• W2094166501 cites W2041607290 @default.
• W2094166501 cites W2047376205 @default.
• W2094166501 cites W2052969143 @default.
• W2094166501 cites W2060988634 @default.
• W2094166501 cites W2070413937 @default.
• W2094166501 cites W2075860675 @default.
• W2094166501 cites W2083089709 @default.
• W2094166501 cites W2097063436 @default.
• W2094166501 cites W2100649505 @default.
• W2094166501 cites W2101619948 @default.
• W2094166501 cites W2106694537 @default.
• W2094166501 cites W2109601788 @default.
• W2094166501 cites W2115090185 @default.
• W2094166501 cites W2120046045 @default.
• W2094166501 cites W2129321855 @default.
• W2094166501 cites W2130827011 @default.
• W2094166501 cites W2132780101 @default.
• W2094166501 cites W2136059996 @default.
• W2094166501 cites W2139041007 @default.
• W2094166501 cites W2143300196 @default.
• W2094166501 cites W2147873632 @default.
• W2094166501 cites W2164317756 @default.
• W2094166501 cites W4248219898 @default.
• W2094166501 doi "https://doi.org/10.1016/j.chom.2010.09.005" @default.
• W2094166501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20951969" @default.
• W2094166501 hasPublicationYear "2010" @default.
• W2094166501 type Work @default.
• W2094166501 sameAs 2094166501 @default.
• W2094166501 citedByCount "190" @default.
• W2094166501 countsByYear W20941665012012 @default.
• W2094166501 countsByYear W20941665012013 @default.
• W2094166501 countsByYear W20941665012014 @default.
• W2094166501 countsByYear W20941665012015 @default.
• W2094166501 countsByYear W20941665012016 @default.
• W2094166501 countsByYear W20941665012017 @default.
• W2094166501 countsByYear W20941665012018 @default.
• W2094166501 countsByYear W20941665012019 @default.
• W2094166501 countsByYear W20941665012020 @default.
• W2094166501 countsByYear W20941665012021 @default.
• W2094166501 countsByYear W20941665012022 @default.
• W2094166501 countsByYear W20941665012023 @default.
• W2094166501 crossrefType "journal-article" @default.
• W2094166501 hasAuthorship W2094166501A5022571530 @default.
• W2094166501 hasAuthorship W2094166501A5023281192 @default.
• W2094166501 hasAuthorship W2094166501A5036467945 @default.
• W2094166501 hasAuthorship W2094166501A5039486913 @default.
• W2094166501 hasAuthorship W2094166501A5066957565 @default.
• W2094166501 hasAuthorship W2094166501A5083360417 @default.
• W2094166501 hasAuthorship W2094166501A5084471744 @default.
• W2094166501 hasBestOaLocation W20941665011 @default.
• W2094166501 hasConcept C104317684 @default.
• W2094166501 hasConcept C126322002 @default.
• W2094166501 hasConcept C136449434 @default.
• W2094166501 hasConcept C145059251 @default.
• W2094166501 hasConcept C150194340 @default.
• W2094166501 hasConcept C170493617 @default.
• W2094166501 hasConcept C186310378 @default.
• W2094166501 hasConcept C203014093 @default.
• W2094166501 hasConcept C2776070231 @default.
• W2094166501 hasConcept C2776709828 @default.
• W2094166501 hasConcept C2777702733 @default.
• W2094166501 hasConcept C2781077229 @default.
• W2094166501 hasConcept C3019368612 @default.
• W2094166501 hasConcept C47742525 @default.
• W2094166501 hasConcept C529295009 @default.
• W2094166501 hasConcept C54355233 @default.
• W2094166501 hasConcept C62478195 @default.
• W2094166501 hasConcept C71924100 @default.
• W2094166501 hasConcept C86339819 @default.
• W2094166501 hasConcept C86803240 @default.
• W2094166501 hasConcept C8891405 @default.
• W2094166501 hasConcept C95444343 @default.
• W2094166501 hasConceptScore W2094166501C104317684 @default.
• W2094166501 hasConceptScore W2094166501C126322002 @default.
• W2094166501 hasConceptScore W2094166501C136449434 @default.

• next