FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094167812> ?p ?o ?g. }

• W2094167812 endingPage "5814" @default.
• W2094167812 startingPage "5809" @default.
• W2094167812 abstract "The structure and dynamics of bacterial communities in the airways of persons with cystic fibrosis (CF) remain largely unknown. We characterized the bacterial communities in 126 sputum samples representing serial collections spanning 8–9 y from six age-matched male CF patients. Sputum DNA was analyzed by bar-coded pyrosequencing of the V3–V5 hypervariable region of the 16S rRNA gene, defining 662 operational taxonomic units (OTUs) from >633,000 sequences. Bacterial community diversity decreased significantly over time in patients with typically progressive lung disease but remained relatively stable in patients with a mild lung disease phenotype. Antibiotic use, rather than patient age or lung function, was the primary driver of decreasing diversity. Interpatient variability in community structure exceeded intrapatient variability in serial samples. Antibiotic treatment was associated with pronounced shifts in community structure, but communities showed both short- and long-term resilience after antibiotic perturbation. There was a positive correlation between OTU occurrence and relative abundance, with a small number of persistent OTUs accounting for the greatest abundance. Significant changes in community structure, diversity, or total bacterial density at the time of pulmonary exacerbation were not observed. Despite decreasing community diversity in patients with progressive disease, total bacterial density remained relatively stable over time. These findings show the critical relationship between airway bacterial community structure, disease stage, and clinical state at the time of sample collection. These features are the key parameters with which to assess the complex ecology of the CF airway." @default.
• W2094167812 created "2016-06-24" @default.
• W2094167812 creator A5004460622 @default.
• W2094167812 creator A5005333977 @default.
• W2094167812 creator A5007210792 @default.
• W2094167812 creator A5012664020 @default.
• W2094167812 creator A5024605926 @default.
• W2094167812 creator A5026573989 @default.
• W2094167812 creator A5036421485 @default.
• W2094167812 creator A5040845006 @default.
• W2094167812 creator A5052692974 @default.
• W2094167812 creator A5062762496 @default.
• W2094167812 creator A5072783446 @default.
• W2094167812 creator A5075444455 @default.
• W2094167812 date "2012-03-26" @default.
• W2094167812 modified "2023-10-11" @default.
• W2094167812 title "Decade-long bacterial community dynamics in cystic fibrosis airways" @default.
• W2094167812 cites W1965165402 @default.
• W2094167812 cites W2009245754 @default.
• W2094167812 cites W2012449112 @default.
• W2094167812 cites W2033168765 @default.
• W2094167812 cites W2088620429 @default.
• W2094167812 cites W2095566399 @default.
• W2094167812 cites W2108718991 @default.
• W2094167812 cites W2121640835 @default.
• W2094167812 cites W2122060678 @default.
• W2094167812 cites W2123989493 @default.
• W2094167812 cites W2147782477 @default.
• W2094167812 cites W2149001759 @default.
• W2094167812 cites W2155737151 @default.
• W2094167812 cites W2157584041 @default.
• W2094167812 cites W2158342176 @default.
• W2094167812 cites W2163064806 @default.
• W2094167812 doi "https://doi.org/10.1073/pnas.1120577109" @default.
• W2094167812 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3326496" @default.
• W2094167812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22451929" @default.
• W2094167812 hasPublicationYear "2012" @default.
• W2094167812 type Work @default.
• W2094167812 sameAs 2094167812 @default.
• W2094167812 citedByCount "517" @default.
• W2094167812 countsByYear W20941678122012 @default.
• W2094167812 countsByYear W20941678122013 @default.
• W2094167812 countsByYear W20941678122014 @default.
• W2094167812 countsByYear W20941678122015 @default.
• W2094167812 countsByYear W20941678122016 @default.
• W2094167812 countsByYear W20941678122017 @default.
• W2094167812 countsByYear W20941678122018 @default.
• W2094167812 countsByYear W20941678122019 @default.
• W2094167812 countsByYear W20941678122020 @default.
• W2094167812 countsByYear W20941678122021 @default.
• W2094167812 countsByYear W20941678122022 @default.
• W2094167812 countsByYear W20941678122023 @default.
• W2094167812 crossrefType "journal-article" @default.
• W2094167812 hasAuthorship W2094167812A5004460622 @default.
• W2094167812 hasAuthorship W2094167812A5005333977 @default.
• W2094167812 hasAuthorship W2094167812A5007210792 @default.
• W2094167812 hasAuthorship W2094167812A5012664020 @default.
• W2094167812 hasAuthorship W2094167812A5024605926 @default.
• W2094167812 hasAuthorship W2094167812A5026573989 @default.
• W2094167812 hasAuthorship W2094167812A5036421485 @default.
• W2094167812 hasAuthorship W2094167812A5040845006 @default.
• W2094167812 hasAuthorship W2094167812A5052692974 @default.
• W2094167812 hasAuthorship W2094167812A5062762496 @default.
• W2094167812 hasAuthorship W2094167812A5072783446 @default.
• W2094167812 hasAuthorship W2094167812A5075444455 @default.
• W2094167812 hasBestOaLocation W20941678121 @default.
• W2094167812 hasConcept C104317684 @default.
• W2094167812 hasConcept C125009961 @default.
• W2094167812 hasConcept C126322002 @default.
• W2094167812 hasConcept C133079900 @default.
• W2094167812 hasConcept C142724271 @default.
• W2094167812 hasConcept C18903297 @default.
• W2094167812 hasConcept C2776301714 @default.
• W2094167812 hasConcept C2776938444 @default.
• W2094167812 hasConcept C2777714996 @default.
• W2094167812 hasConcept C2781069245 @default.
• W2094167812 hasConcept C54355233 @default.
• W2094167812 hasConcept C71924100 @default.
• W2094167812 hasConcept C86803240 @default.
• W2094167812 hasConcept C89423630 @default.
• W2094167812 hasConceptScore W2094167812C104317684 @default.
• W2094167812 hasConceptScore W2094167812C125009961 @default.
• W2094167812 hasConceptScore W2094167812C126322002 @default.
• W2094167812 hasConceptScore W2094167812C133079900 @default.
• W2094167812 hasConceptScore W2094167812C142724271 @default.
• W2094167812 hasConceptScore W2094167812C18903297 @default.
• W2094167812 hasConceptScore W2094167812C2776301714 @default.
• W2094167812 hasConceptScore W2094167812C2776938444 @default.
• W2094167812 hasConceptScore W2094167812C2777714996 @default.
• W2094167812 hasConceptScore W2094167812C2781069245 @default.
• W2094167812 hasConceptScore W2094167812C54355233 @default.
• W2094167812 hasConceptScore W2094167812C71924100 @default.
• W2094167812 hasConceptScore W2094167812C86803240 @default.
• W2094167812 hasConceptScore W2094167812C89423630 @default.
• W2094167812 hasIssue "15" @default.
• W2094167812 hasLocation W20941678121 @default.
• W2094167812 hasLocation W20941678122 @default.
• W2094167812 hasLocation W20941678123 @default.

• next