Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094171472> ?p ?o ?g. }
- W2094171472 endingPage "1131" @default.
- W2094171472 startingPage "1125" @default.
- W2094171472 abstract "Smac mimetics are potential anticancer therapeutics selectively killing cancer cells through autocrine tumor necrosis factor (TNF)-mediated apoptosis pathway. Our recent study reveal that the Smac mimetic compound 3 (SMC3)-activated NF-kappaB protects cancer cells against apoptosis, thus blunting SMC3's anticancer activity. Based on our previous observations that the nutrient flavonoid luteolin potently blocks TNF-induced NF-kappaB activation in cancer cells, we investigated if the combination of SMC3 and luteolin would achieve a synergistic anticancer activity. The results show that luteolin had no effect on autocrine TNF but it effectively blocked SMC3-induced nuclear factor kappa B (NF-kappaB) activation and expression of anti-apoptotic NF-kappaB targets. When SMC3 and luteolin were combined in treating cancer cells derived from lung and liver tumors, the activation of TNF-dependent apoptosis was markedly sensitized and a synergistic cytotoxic effect was achieved. In addition, the SMC3 and luteolin co-treatment had marginal effect on immortalized normal human bronchial epithelial cells. The results suggest that combination of SMC3 and luteolin is an effective approach for improving the anticancer value of SMC3, which has implications in cancer prevention and therapy." @default.
- W2094171472 created "2016-06-24" @default.
- W2094171472 creator A5000752349 @default.
- W2094171472 creator A5005424988 @default.
- W2094171472 creator A5007375337 @default.
- W2094171472 creator A5042489662 @default.
- W2094171472 creator A5049798132 @default.
- W2094171472 creator A5050015844 @default.
- W2094171472 date "2009-12-01" @default.
- W2094171472 modified "2023-10-18" @default.
- W2094171472 title "Attenuating Smac mimetic compound 3-induced NF-κB activation by luteolin leads to synergistic cytotoxicity in cancer cells" @default.
- W2094171472 cites W1986978728 @default.
- W2094171472 cites W1998423564 @default.
- W2094171472 cites W2004779806 @default.
- W2094171472 cites W2005572311 @default.
- W2094171472 cites W2025062631 @default.
- W2094171472 cites W2033882650 @default.
- W2094171472 cites W2034269086 @default.
- W2094171472 cites W2034625230 @default.
- W2094171472 cites W2037470777 @default.
- W2094171472 cites W2038053883 @default.
- W2094171472 cites W2042409437 @default.
- W2094171472 cites W2054198032 @default.
- W2094171472 cites W2061294496 @default.
- W2094171472 cites W2064299413 @default.
- W2094171472 cites W2065036369 @default.
- W2094171472 cites W2069800916 @default.
- W2094171472 cites W2080207536 @default.
- W2094171472 cites W2089994544 @default.
- W2094171472 cites W2095013915 @default.
- W2094171472 cites W2101976092 @default.
- W2094171472 cites W2107411016 @default.
- W2094171472 cites W2109069677 @default.
- W2094171472 cites W2110823811 @default.
- W2094171472 cites W2116609506 @default.
- W2094171472 cites W2120130492 @default.
- W2094171472 cites W2120956629 @default.
- W2094171472 cites W2123513769 @default.
- W2094171472 cites W2127281537 @default.
- W2094171472 cites W2153183522 @default.
- W2094171472 cites W2162653594 @default.
- W2094171472 cites W2162966642 @default.
- W2094171472 cites W2168919362 @default.
- W2094171472 doi "https://doi.org/10.1002/jcb.22346" @default.
- W2094171472 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3071149" @default.
- W2094171472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19739098" @default.
- W2094171472 hasPublicationYear "2009" @default.
- W2094171472 type Work @default.
- W2094171472 sameAs 2094171472 @default.
- W2094171472 citedByCount "11" @default.
- W2094171472 countsByYear W20941714722012 @default.
- W2094171472 countsByYear W20941714722013 @default.
- W2094171472 countsByYear W20941714722014 @default.
- W2094171472 countsByYear W20941714722015 @default.
- W2094171472 countsByYear W20941714722018 @default.
- W2094171472 crossrefType "journal-article" @default.
- W2094171472 hasAuthorship W2094171472A5000752349 @default.
- W2094171472 hasAuthorship W2094171472A5005424988 @default.
- W2094171472 hasAuthorship W2094171472A5007375337 @default.
- W2094171472 hasAuthorship W2094171472A5042489662 @default.
- W2094171472 hasAuthorship W2094171472A5049798132 @default.
- W2094171472 hasAuthorship W2094171472A5050015844 @default.
- W2094171472 hasBestOaLocation W20941714722 @default.
- W2094171472 hasConcept C109316439 @default.
- W2094171472 hasConcept C121608353 @default.
- W2094171472 hasConcept C128240485 @default.
- W2094171472 hasConcept C154317977 @default.
- W2094171472 hasConcept C17991360 @default.
- W2094171472 hasConcept C190283241 @default.
- W2094171472 hasConcept C202751555 @default.
- W2094171472 hasConcept C203014093 @default.
- W2094171472 hasConcept C2776080593 @default.
- W2094171472 hasConcept C2777730290 @default.
- W2094171472 hasConcept C2778004101 @default.
- W2094171472 hasConcept C2779054382 @default.
- W2094171472 hasConcept C502942594 @default.
- W2094171472 hasConcept C54355233 @default.
- W2094171472 hasConcept C55493867 @default.
- W2094171472 hasConcept C81885089 @default.
- W2094171472 hasConcept C86803240 @default.
- W2094171472 hasConcept C96232424 @default.
- W2094171472 hasConcept C98274493 @default.
- W2094171472 hasConceptScore W2094171472C109316439 @default.
- W2094171472 hasConceptScore W2094171472C121608353 @default.
- W2094171472 hasConceptScore W2094171472C128240485 @default.
- W2094171472 hasConceptScore W2094171472C154317977 @default.
- W2094171472 hasConceptScore W2094171472C17991360 @default.
- W2094171472 hasConceptScore W2094171472C190283241 @default.
- W2094171472 hasConceptScore W2094171472C202751555 @default.
- W2094171472 hasConceptScore W2094171472C203014093 @default.
- W2094171472 hasConceptScore W2094171472C2776080593 @default.
- W2094171472 hasConceptScore W2094171472C2777730290 @default.
- W2094171472 hasConceptScore W2094171472C2778004101 @default.
- W2094171472 hasConceptScore W2094171472C2779054382 @default.
- W2094171472 hasConceptScore W2094171472C502942594 @default.
- W2094171472 hasConceptScore W2094171472C54355233 @default.
- W2094171472 hasConceptScore W2094171472C55493867 @default.
- W2094171472 hasConceptScore W2094171472C81885089 @default.