Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094173634> ?p ?o ?g. }
- W2094173634 endingPage "E1622" @default.
- W2094173634 startingPage "E1615" @default.
- W2094173634 abstract "In Brief Study Design. A study of cervical interbody fusion using polyamino acid-based bioabsorbable fusion cages in a goat model. Objective. To compare interbody fusion of a bioabsorbable multiamino acid copolymer/α-tri-calcium phosphate (MAACP/α-TCP) fusion cage with an autologous tricortical iliac-crest bone graft and a titanium cage. Summary of Background Data. Polyamino acid is widely used as a carrier for drug delivery. To our knowledge, no study investigates interbody fusion cage made of polyamino acid. Methods. A total of 15 sheep underwent C3/C4 discectomy and fusion. The following stabilization techniques were used: group A, autologous tricortical iliac crest bone graft (n = 5); group B, MAACP/α-TCP cage filled with autologous cancellous bone graft (n = 5); group C, titanium cage filled with autologous cancellous bone graft (n = 5). Radiographic scans to determine disc space height were performed before and after surgery and after 4, 8, and 12 weeks, respectively. After 12 weeks, the C3/C4 motion segment was isolated and sectioned to create a 5-mm thick parasagittal section from which lateral radiographs were obtained. All the radiographs were encoded and reviewed in a blinded fashion to evaluate interbody fusion within the cage devices according to a three-point radiographic score. Biomechanical testing was performed in flexion, extension, axial rotation, and lateral bending to determine range of motion (ROM). Histomorphological and histomorphometrical analyses were performed to evaluate fusion and foreign-body reactions associated with the bioabsorbable cages. Results. Radiographic results showed that the disc space height (DSH) in MAACP/α-TCP cage group was better than that of bone graft group and the best radiographic score was found in MAACP/α-TCP cage group. Biomechanical test showed that no significant difference was found in ROM between MAACP/α-TCP cage group and titanium cage group whereas the value of ROM in bone graft group was the largest. Histologic evaluation showed a higher intervertebral bone volume/total volume ratio and a better interbody fusion in the MAACP/α-TCP cage group than in the other two groups. Two MAACP/α-TCP cages showed microcracks and the other three cages had maintained their original geometry. All MAACP/α-TCP cages showed excellent biocompatibility. Conclusion. After 12 weeks, there was no significant difference between the MAACP/α-TCP cage and the titanium cage in distractive properties and biomechanical properties. Compared with titanium cages, MAACP/α-TCP cages showed an advanced interbody fusion. Although MAACP/α-TCP cages developed cracks after only 12 weeks, they showed significantly better distractive properties, biomechanical properties, and an advanced interbody fusion than the tricortical iliac crest bone graft. Improvement should be made to insure the strength of MAACP/α-TCP cage last at least 6 month after implantion. This study compared interbody fusion of a bioabsorbable multiamino acid copolymer/α-tri-calcium phosphate (MAACP/α-TCP) cage with an autologous bone graft and a titanium cage in a goat model. Although MAACP/α-TCP cages showed cracks after 12 weeks, they demonstrated an advanced interbody fusion superior to the bone graft and the titanium cage." @default.
- W2094173634 created "2016-06-24" @default.
- W2094173634 creator A5001369345 @default.
- W2094173634 creator A5008037931 @default.
- W2094173634 creator A5039921012 @default.
- W2094173634 creator A5054546906 @default.
- W2094173634 creator A5078095227 @default.
- W2094173634 creator A5079746101 @default.
- W2094173634 creator A5085577165 @default.
- W2094173634 date "2011-12-01" @default.
- W2094173634 modified "2023-09-25" @default.
- W2094173634 title "Evaluation of Bioabsorbable Multiamino Acid Copolymer/α-Tri-Calcium Phosphate Interbody Fusion Cages in a Goat Model" @default.
- W2094173634 cites W1529040495 @default.
- W2094173634 cites W1963647565 @default.
- W2094173634 cites W1995457505 @default.
- W2094173634 cites W1996705833 @default.
- W2094173634 cites W1997720718 @default.
- W2094173634 cites W1998382163 @default.
- W2094173634 cites W2002992580 @default.
- W2094173634 cites W2008483247 @default.
- W2094173634 cites W2013300088 @default.
- W2094173634 cites W2019672131 @default.
- W2094173634 cites W2020085931 @default.
- W2094173634 cites W2021407441 @default.
- W2094173634 cites W2030279549 @default.
- W2094173634 cites W2037170571 @default.
- W2094173634 cites W2037732161 @default.
- W2094173634 cites W2038958827 @default.
- W2094173634 cites W2042322894 @default.
- W2094173634 cites W2042560157 @default.
- W2094173634 cites W2048597321 @default.
- W2094173634 cites W2053115218 @default.
- W2094173634 cites W2053958852 @default.
- W2094173634 cites W2054121842 @default.
- W2094173634 cites W2058510952 @default.
- W2094173634 cites W2058759505 @default.
- W2094173634 cites W2060291349 @default.
- W2094173634 cites W2088228505 @default.
- W2094173634 cites W2089584512 @default.
- W2094173634 cites W2092283338 @default.
- W2094173634 cites W2102176544 @default.
- W2094173634 cites W2106799396 @default.
- W2094173634 cites W2109314518 @default.
- W2094173634 cites W2115223136 @default.
- W2094173634 cites W2138279679 @default.
- W2094173634 cites W2145747253 @default.
- W2094173634 cites W2151540091 @default.
- W2094173634 cites W2151767011 @default.
- W2094173634 cites W2152930324 @default.
- W2094173634 cites W2231775894 @default.
- W2094173634 cites W3023069978 @default.
- W2094173634 cites W54668368 @default.
- W2094173634 doi "https://doi.org/10.1097/brs.0b013e318210ca32" @default.
- W2094173634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21270683" @default.
- W2094173634 hasPublicationYear "2011" @default.
- W2094173634 type Work @default.
- W2094173634 sameAs 2094173634 @default.
- W2094173634 citedByCount "12" @default.
- W2094173634 countsByYear W20941736342013 @default.
- W2094173634 countsByYear W20941736342014 @default.
- W2094173634 countsByYear W20941736342016 @default.
- W2094173634 countsByYear W20941736342017 @default.
- W2094173634 countsByYear W20941736342018 @default.
- W2094173634 countsByYear W20941736342019 @default.
- W2094173634 countsByYear W20941736342020 @default.
- W2094173634 countsByYear W20941736342021 @default.
- W2094173634 crossrefType "journal-article" @default.
- W2094173634 hasAuthorship W2094173634A5001369345 @default.
- W2094173634 hasAuthorship W2094173634A5008037931 @default.
- W2094173634 hasAuthorship W2094173634A5039921012 @default.
- W2094173634 hasAuthorship W2094173634A5054546906 @default.
- W2094173634 hasAuthorship W2094173634A5078095227 @default.
- W2094173634 hasAuthorship W2094173634A5079746101 @default.
- W2094173634 hasAuthorship W2094173634A5085577165 @default.
- W2094173634 hasConcept C114614502 @default.
- W2094173634 hasConcept C141071460 @default.
- W2094173634 hasConcept C142724271 @default.
- W2094173634 hasConcept C160272327 @default.
- W2094173634 hasConcept C204787440 @default.
- W2094173634 hasConcept C2776008035 @default.
- W2094173634 hasConcept C2776350087 @default.
- W2094173634 hasConcept C2779079599 @default.
- W2094173634 hasConcept C2780375110 @default.
- W2094173634 hasConcept C2781298600 @default.
- W2094173634 hasConcept C2781430139 @default.
- W2094173634 hasConcept C2985379065 @default.
- W2094173634 hasConcept C33923547 @default.
- W2094173634 hasConcept C36454342 @default.
- W2094173634 hasConcept C44575665 @default.
- W2094173634 hasConcept C60465272 @default.
- W2094173634 hasConcept C71924100 @default.
- W2094173634 hasConceptScore W2094173634C114614502 @default.
- W2094173634 hasConceptScore W2094173634C141071460 @default.
- W2094173634 hasConceptScore W2094173634C142724271 @default.
- W2094173634 hasConceptScore W2094173634C160272327 @default.
- W2094173634 hasConceptScore W2094173634C204787440 @default.
- W2094173634 hasConceptScore W2094173634C2776008035 @default.
- W2094173634 hasConceptScore W2094173634C2776350087 @default.