FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094174707> ?p ?o ?g. }

• W2094174707 endingPage "197" @default.
• W2094174707 startingPage "191" @default.
• W2094174707 abstract "The ability of the human immunodeficiency virus (HIV) to replicate in CD4+ T lymphocytes and mononuclear phagocytes(MP) is strongly influenced by immunoregulatory cytokines. In the T cell system, interleukin-2 (IL-2) provides a mitogenic signal leading to both cell proliferation and virus replication. Among other HIV-inductive cytokines, only tumor necrosis factor-α or -β (TNF-β/-β) have been shown thus far to trigger virus expression both in T cells and MP. The mechanism of action of TNF involves the activation of the cellular transcription factor NF-kB which binds to specific consensus sequences present in the enhancer region of the HIV proviral LTR. In addition, several other cytokines (including colony stimulating factors, IL-1, IL-3, and IL-6) have demonstrated upregulatory effects on HIV production in MP, whereas nonimmune interferons (INF-β/-β) have been shown to suppress HIV replication in T cells and MP by acting at different phases in the virus life cycle. Finally, cytokines such as TGF-β, IFN-β, and IL-4 have demonstrated either upregulatory or suppressive effects on virus expression depending on the experimental conditions. This scenario indicates that HIV expression is under the control of a complex network of immunoregulatory cytokines, in addition to its own endogenous regulatory proteins, suggesting that new pharmacologic strategies may be aimed at either mimicking or interrupting cytokine-dependent virus expression. In this regard, a number of different physiologic and pharmacologic agents capable of interfering with cytokine-mediated events, including glucocorticoids, anti-oxidants, such as N-Acetyl-L-Cysteine (NAC), and retinoic acid (RA) have already been shown to profoundly affect HIV replication in vitro." @default.
• W2094174707 created "2016-06-24" @default.
• W2094174707 creator A5018618408 @default.
• W2094174707 creator A5031736334 @default.
• W2094174707 date "1992-02-01" @default.
• W2094174707 modified "2023-09-23" @default.
• W2094174707 title "The Effect of Cytokines and Pharmacologic Agents on Chronic HIV Infection" @default.
• W2094174707 cites W1519144004 @default.
• W2094174707 cites W1568529372 @default.
• W2094174707 cites W1591647953 @default.
• W2094174707 cites W1617254133 @default.
• W2094174707 cites W1696738055 @default.
• W2094174707 cites W1923033021 @default.
• W2094174707 cites W1966884218 @default.
• W2094174707 cites W1968336349 @default.
• W2094174707 cites W1971373864 @default.
• W2094174707 cites W1975258429 @default.
• W2094174707 cites W1976000267 @default.
• W2094174707 cites W1977282539 @default.
• W2094174707 cites W1978770042 @default.
• W2094174707 cites W1979568878 @default.
• W2094174707 cites W1979989842 @default.
• W2094174707 cites W1983671664 @default.
• W2094174707 cites W1984511547 @default.
• W2094174707 cites W1988464146 @default.
• W2094174707 cites W1989417613 @default.
• W2094174707 cites W1990273009 @default.
• W2094174707 cites W1991601077 @default.
• W2094174707 cites W2004405778 @default.
• W2094174707 cites W2010479937 @default.
• W2094174707 cites W2011406016 @default.
• W2094174707 cites W2012744796 @default.
• W2094174707 cites W2019508559 @default.
• W2094174707 cites W2020007222 @default.
• W2094174707 cites W2031089158 @default.
• W2094174707 cites W2035166969 @default.
• W2094174707 cites W2036086605 @default.
• W2094174707 cites W2036890038 @default.
• W2094174707 cites W2037696254 @default.
• W2094174707 cites W2041709827 @default.
• W2094174707 cites W2043541788 @default.
• W2094174707 cites W2044179867 @default.
• W2094174707 cites W2047385013 @default.
• W2094174707 cites W2048158801 @default.
• W2094174707 cites W2049100633 @default.
• W2094174707 cites W2050937329 @default.
• W2094174707 cites W2053905319 @default.
• W2094174707 cites W2054134754 @default.
• W2094174707 cites W2060383070 @default.
• W2094174707 cites W2067092255 @default.
• W2094174707 cites W2070558900 @default.
• W2094174707 cites W2072409481 @default.
• W2094174707 cites W2077468566 @default.
• W2094174707 cites W2077847842 @default.
• W2094174707 cites W2079999509 @default.
• W2094174707 cites W2081911212 @default.
• W2094174707 cites W2082912386 @default.
• W2094174707 cites W2085721436 @default.
• W2094174707 cites W2088493593 @default.
• W2094174707 cites W2094531254 @default.
• W2094174707 cites W2112620503 @default.
• W2094174707 cites W2116696460 @default.
• W2094174707 cites W2123742848 @default.
• W2094174707 cites W2128901455 @default.
• W2094174707 cites W2137267461 @default.
• W2094174707 cites W2141900205 @default.
• W2094174707 cites W2303775313 @default.
• W2094174707 cites W2327237185 @default.
• W2094174707 cites W2333133071 @default.
• W2094174707 cites W286305977 @default.
• W2094174707 cites W4240405306 @default.
• W2094174707 cites W4245957869 @default.
• W2094174707 cites W4293052535 @default.
• W2094174707 doi "https://doi.org/10.1089/aid.1992.8.191" @default.
• W2094174707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1540407" @default.
• W2094174707 hasPublicationYear "1992" @default.
• W2094174707 type Work @default.
• W2094174707 sameAs 2094174707 @default.
• W2094174707 citedByCount "229" @default.
• W2094174707 countsByYear W20941747072012 @default.
• W2094174707 countsByYear W20941747072013 @default.
• W2094174707 countsByYear W20941747072014 @default.
• W2094174707 countsByYear W20941747072015 @default.
• W2094174707 countsByYear W20941747072016 @default.
• W2094174707 countsByYear W20941747072018 @default.
• W2094174707 countsByYear W20941747072019 @default.
• W2094174707 countsByYear W20941747072020 @default.
• W2094174707 countsByYear W20941747072022 @default.
• W2094174707 countsByYear W20941747072023 @default.
• W2094174707 crossrefType "journal-article" @default.
• W2094174707 hasAuthorship W2094174707A5018618408 @default.
• W2094174707 hasAuthorship W2094174707A5031736334 @default.
• W2094174707 hasConcept C104317684 @default.
• W2094174707 hasConcept C136449434 @default.
• W2094174707 hasConcept C140704245 @default.
• W2094174707 hasConcept C159047783 @default.
• W2094174707 hasConcept C164027704 @default.
• W2094174707 hasConcept C17991360 @default.

• next