FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094177876> ?p ?o ?g. }

• W2094177876 endingPage "F228" @default.
• W2094177876 startingPage "F220" @default.
• W2094177876 abstract "Epithelial sodium channels (ENaC) are critically important in the regulation of ion and fluid balance in both renal and respiratory epithelia. ENaC functional polymorphisms may contribute to alterations in blood pressure in the general population. We previously reported that the A663T polymorphism in the C terminus of the α-subunit altered ENaC functional and surface expression in Xenopus laevis oocytes (Samaha FF, Rubenstein RC, Yan W, Ramkumar M, Levy DI, Ahn YJ, Sheng S, Kleyman TR. J Biol Chem 279: 23900–23907, 2004). We examined whether sites in the vicinity of 663 influenced channel activity by performing scanning Ala mutagenesis. Interestingly, only αT663/G667Aβγ channels exhibited increased currents compared with αT663βγ. This increase in channel activity reflected an increase in channel open probability and not an increase in channel surface expression. In contrast, decreases in channel activity were observed with both αT663/C664Aβγ and αT663/C664Mβγ channels. The decrease in functional expression of αT663/C664Mβγ channels correlated with decreased surface expression, suggesting that the αC664M mutation altered the intracellular trafficking of the channel. While cytoplasmic Cys residues may be modified by the addition of palmitate, we did not observe palmitoylation of αC664. Our results suggest that multiple residues in the distal part of the cytoplasmic C terminus have roles in modulating channel activity." @default.
• W2094177876 created "2016-06-24" @default.
• W2094177876 creator A5002272100 @default.
• W2094177876 creator A5009040560 @default.
• W2094177876 creator A5017601084 @default.
• W2094177876 creator A5066242939 @default.
• W2094177876 creator A5068675129 @default.
• W2094177876 creator A5072047377 @default.
• W2094177876 creator A5075102222 @default.
• W2094177876 creator A5077733949 @default.
• W2094177876 creator A5085236573 @default.
• W2094177876 creator A5088195948 @default.
• W2094177876 date "2012-07-15" @default.
• W2094177876 modified "2023-09-26" @default.
• W2094177876 title "Multiple residues in the distal C terminus of the α-subunit have roles in modulating human epithelial sodium channel activity" @default.
• W2094177876 cites W1975983905 @default.
• W2094177876 cites W1983524637 @default.
• W2094177876 cites W1987616856 @default.
• W2094177876 cites W1995665478 @default.
• W2094177876 cites W2001295971 @default.
• W2094177876 cites W2006363853 @default.
• W2094177876 cites W2013711061 @default.
• W2094177876 cites W2034728504 @default.
• W2094177876 cites W2041344034 @default.
• W2094177876 cites W2059116113 @default.
• W2094177876 cites W2071201135 @default.
• W2094177876 cites W2072819360 @default.
• W2094177876 cites W2076996214 @default.
• W2094177876 cites W2080619896 @default.
• W2094177876 cites W2083639357 @default.
• W2094177876 cites W2091425609 @default.
• W2094177876 cites W2099258590 @default.
• W2094177876 cites W2107659950 @default.
• W2094177876 cites W2109328478 @default.
• W2094177876 cites W2124924883 @default.
• W2094177876 cites W2140853270 @default.
• W2094177876 cites W2145346414 @default.
• W2094177876 cites W2146061587 @default.
• W2094177876 cites W2150867522 @default.
• W2094177876 cites W2152909964 @default.
• W2094177876 cites W2158237852 @default.
• W2094177876 cites W2160567247 @default.
• W2094177876 cites W2160907651 @default.
• W2094177876 cites W2161647218 @default.
• W2094177876 cites W2162445321 @default.
• W2094177876 cites W2164709148 @default.
• W2094177876 cites W2171143022 @default.
• W2094177876 cites W2301973105 @default.
• W2094177876 cites W2312795520 @default.
• W2094177876 doi "https://doi.org/10.1152/ajprenal.00493.2011" @default.
• W2094177876 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3404586" @default.
• W2094177876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22573385" @default.
• W2094177876 hasPublicationYear "2012" @default.
• W2094177876 type Work @default.
• W2094177876 sameAs 2094177876 @default.
• W2094177876 citedByCount "9" @default.
• W2094177876 countsByYear W20941778762013 @default.
• W2094177876 countsByYear W20941778762014 @default.
• W2094177876 countsByYear W20941778762015 @default.
• W2094177876 countsByYear W20941778762016 @default.
• W2094177876 countsByYear W20941778762017 @default.
• W2094177876 countsByYear W20941778762018 @default.
• W2094177876 countsByYear W20941778762023 @default.
• W2094177876 crossrefType "journal-article" @default.
• W2094177876 hasAuthorship W2094177876A5002272100 @default.
• W2094177876 hasAuthorship W2094177876A5009040560 @default.
• W2094177876 hasAuthorship W2094177876A5017601084 @default.
• W2094177876 hasAuthorship W2094177876A5066242939 @default.
• W2094177876 hasAuthorship W2094177876A5068675129 @default.
• W2094177876 hasAuthorship W2094177876A5072047377 @default.
• W2094177876 hasAuthorship W2094177876A5075102222 @default.
• W2094177876 hasAuthorship W2094177876A5077733949 @default.
• W2094177876 hasAuthorship W2094177876A5085236573 @default.
• W2094177876 hasAuthorship W2094177876A5088195948 @default.
• W2094177876 hasBestOaLocation W20941778762 @default.
• W2094177876 hasConcept C104292427 @default.
• W2094177876 hasConcept C104317684 @default.
• W2094177876 hasConcept C134018914 @default.
• W2094177876 hasConcept C153911025 @default.
• W2094177876 hasConcept C170493617 @default.
• W2094177876 hasConcept C178790620 @default.
• W2094177876 hasConcept C185592680 @default.
• W2094177876 hasConcept C190062978 @default.
• W2094177876 hasConcept C2779535977 @default.
• W2094177876 hasConcept C2908647359 @default.
• W2094177876 hasConcept C50254741 @default.
• W2094177876 hasConcept C50952357 @default.
• W2094177876 hasConcept C537181965 @default.
• W2094177876 hasConcept C55493867 @default.
• W2094177876 hasConcept C6507245 @default.
• W2094177876 hasConcept C71924100 @default.
• W2094177876 hasConcept C86803240 @default.
• W2094177876 hasConcept C95444343 @default.
• W2094177876 hasConcept C99454951 @default.
• W2094177876 hasConceptScore W2094177876C104292427 @default.
• W2094177876 hasConceptScore W2094177876C104317684 @default.
• W2094177876 hasConceptScore W2094177876C134018914 @default.
• W2094177876 hasConceptScore W2094177876C153911025 @default.

• next