Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094190939> ?p ?o ?g. }
- W2094190939 endingPage "109" @default.
- W2094190939 startingPage "99" @default.
- W2094190939 abstract "Single rat hepatocytes, microinjected with the Ca(2+)-sensitive photoprotein aequorin, respond to agonists acting through the phosphoinositide signalling pathway by the generation of oscillations in cytosolic free Ca2+ concentration ([Ca2+]i). The duration of [Ca2+]i transients generated is characteristic of the receptor species activated; the variability results in differences in the rate of fall of [Ca2+]i from its peak. It is conceivable that the plasma membrane Ca(2+)-ATPase (PM Ca2+ pump) may have an important role in the mechanism underlying agonist specificity. It has recently been shown that an esterified form of carboxyeosin, an inhibitor of the red cell PM Ca2+ pump, is suitable for use in whole cell studies. Glucagon-(19-29) (mini-glucagon) inhibits the Ca2+ pump in liver plasma membranes, mediated by Gs. We show here that carboxyeosin and mini-glucagon inhibit Ca2+ efflux from populations of intact rat hepatocytes. We show that carboxyeosin and mini-glucagon enhance the frequency of oscillations induced by Ca(2+)-mobilizing agonists in single hepatocytes, but do not affect the duration of individual transients. Furthermore, we demonstrate that inhibition of the hepatocyte PM Ca2+ pump enables the continued generation of [Ca2+]i oscillations for a prolonged period following the removal of extracellular Ca2+." @default.
- W2094190939 created "2016-06-24" @default.
- W2094190939 creator A5021381146 @default.
- W2094190939 creator A5025181117 @default.
- W2094190939 creator A5066322692 @default.
- W2094190939 date "1997-08-01" @default.
- W2094190939 modified "2023-10-15" @default.
- W2094190939 title "Effects on the hepatocyte [Ca2+]i oscillator of inhibition of the plasma membrane Ca2+ pump by carboxyeosin or glucagon-(19–29)" @default.
- W2094190939 cites W1487088904 @default.
- W2094190939 cites W1492343139 @default.
- W2094190939 cites W1494209531 @default.
- W2094190939 cites W1503015871 @default.
- W2094190939 cites W1511146279 @default.
- W2094190939 cites W1518984641 @default.
- W2094190939 cites W1524384907 @default.
- W2094190939 cites W1530488971 @default.
- W2094190939 cites W1581973776 @default.
- W2094190939 cites W1595287910 @default.
- W2094190939 cites W164157869 @default.
- W2094190939 cites W1673140014 @default.
- W2094190939 cites W172407834 @default.
- W2094190939 cites W1926574943 @default.
- W2094190939 cites W1934331785 @default.
- W2094190939 cites W1978621039 @default.
- W2094190939 cites W1980436095 @default.
- W2094190939 cites W1992629234 @default.
- W2094190939 cites W2006659213 @default.
- W2094190939 cites W2010070719 @default.
- W2094190939 cites W2027850598 @default.
- W2094190939 cites W2028469352 @default.
- W2094190939 cites W2043545589 @default.
- W2094190939 cites W2044070752 @default.
- W2094190939 cites W2049511901 @default.
- W2094190939 cites W2052540730 @default.
- W2094190939 cites W2055574874 @default.
- W2094190939 cites W2062456307 @default.
- W2094190939 cites W2065899907 @default.
- W2094190939 cites W2108169205 @default.
- W2094190939 cites W2132020713 @default.
- W2094190939 cites W2136623476 @default.
- W2094190939 cites W2164891652 @default.
- W2094190939 cites W2213628389 @default.
- W2094190939 cites W2232449214 @default.
- W2094190939 cites W2291772333 @default.
- W2094190939 cites W2309512786 @default.
- W2094190939 cites W2336225226 @default.
- W2094190939 cites W2414393060 @default.
- W2094190939 doi "https://doi.org/10.1016/s0143-4160(97)90110-x" @default.
- W2094190939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9292228" @default.
- W2094190939 hasPublicationYear "1997" @default.
- W2094190939 type Work @default.
- W2094190939 sameAs 2094190939 @default.
- W2094190939 citedByCount "29" @default.
- W2094190939 countsByYear W20941909392012 @default.
- W2094190939 countsByYear W20941909392013 @default.
- W2094190939 countsByYear W20941909392014 @default.
- W2094190939 countsByYear W20941909392017 @default.
- W2094190939 crossrefType "journal-article" @default.
- W2094190939 hasAuthorship W2094190939A5021381146 @default.
- W2094190939 hasAuthorship W2094190939A5025181117 @default.
- W2094190939 hasAuthorship W2094190939A5066322692 @default.
- W2094190939 hasConcept C12554922 @default.
- W2094190939 hasConcept C126322002 @default.
- W2094190939 hasConcept C134018914 @default.
- W2094190939 hasConcept C170493617 @default.
- W2094190939 hasConcept C17189327 @default.
- W2094190939 hasConcept C178790620 @default.
- W2094190939 hasConcept C181199279 @default.
- W2094190939 hasConcept C185592680 @default.
- W2094190939 hasConcept C202751555 @default.
- W2094190939 hasConcept C23265538 @default.
- W2094190939 hasConcept C2776200302 @default.
- W2094190939 hasConcept C2778563252 @default.
- W2094190939 hasConcept C2778938600 @default.
- W2094190939 hasConcept C28406088 @default.
- W2094190939 hasConcept C51705589 @default.
- W2094190939 hasConcept C519063684 @default.
- W2094190939 hasConcept C55493867 @default.
- W2094190939 hasConcept C71315377 @default.
- W2094190939 hasConcept C71924100 @default.
- W2094190939 hasConcept C79879829 @default.
- W2094190939 hasConcept C80933277 @default.
- W2094190939 hasConcept C86803240 @default.
- W2094190939 hasConcept C935647 @default.
- W2094190939 hasConcept C95444343 @default.
- W2094190939 hasConcept C98539663 @default.
- W2094190939 hasConceptScore W2094190939C12554922 @default.
- W2094190939 hasConceptScore W2094190939C126322002 @default.
- W2094190939 hasConceptScore W2094190939C134018914 @default.
- W2094190939 hasConceptScore W2094190939C170493617 @default.
- W2094190939 hasConceptScore W2094190939C17189327 @default.
- W2094190939 hasConceptScore W2094190939C178790620 @default.
- W2094190939 hasConceptScore W2094190939C181199279 @default.
- W2094190939 hasConceptScore W2094190939C185592680 @default.
- W2094190939 hasConceptScore W2094190939C202751555 @default.
- W2094190939 hasConceptScore W2094190939C23265538 @default.
- W2094190939 hasConceptScore W2094190939C2776200302 @default.
- W2094190939 hasConceptScore W2094190939C2778563252 @default.