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• W2094197344 abstract "Skin undergoes self-renewal throughout life. Terminally differentiated keratinocytes, namely the corneocytes, are continually shed from the surface of the skin, whereas immature cells produce progeny that proceed through the differentiation process. Notch signaling controls a number of cellular processes including cell fate decision, proliferation, differentiation and survival/apoptosis. Hence, Notch and its ligands are expressed in multiple tissues including the skin, where they are abundantly expressed in the epidermis. Notch activation results in the promotion of growth arrest and the onset of differentiation, therefore suggesting that specific Notch activation may regulate skin homeostasis by balancing these processes, i.e. Notch signaling functions as a molecular switch that controls the transition of cells between skin layers during the epidermal differentiation process. Recent advances in the study of Notch signaling have confirmed that there is cross-talk between the Notch signaling pathway and a variety of other signaling molecules including Sonic hedgehog (Shh), β-catenin and the p53 family member, p63. The absence of Notch activity allows Wnt and Shh signaling to persist in a tissue where they are normally repressed. In addition, Notch counteracts the action of p63 to maintain immature cell characteristics. However, aberrant Notch signaling results in the development of psoriasis and skin cancers such as squamous cell carcinoma, basal cell carcinoma and malignant melanoma. Future efforts to further define how Notch controls cell proliferation and differentiation may lead to the application of Notch in new therapies for various skin diseases. Skin undergoes self-renewal throughout life. Terminally differentiated keratinocytes, namely the corneocytes, are continually shed from the surface of the skin, whereas immature cells produce progeny that proceed through the differentiation process. Notch signaling controls a number of cellular processes including cell fate decision, proliferation, differentiation and survival/apoptosis. Hence, Notch and its ligands are expressed in multiple tissues including the skin, where they are abundantly expressed in the epidermis. Notch activation results in the promotion of growth arrest and the onset of differentiation, therefore suggesting that specific Notch activation may regulate skin homeostasis by balancing these processes, i.e. Notch signaling functions as a molecular switch that controls the transition of cells between skin layers during the epidermal differentiation process. Recent advances in the study of Notch signaling have confirmed that there is cross-talk between the Notch signaling pathway and a variety of other signaling molecules including Sonic hedgehog (Shh), β-catenin and the p53 family member, p63. The absence of Notch activity allows Wnt and Shh signaling to persist in a tissue where they are normally repressed. In addition, Notch counteracts the action of p63 to maintain immature cell characteristics. However, aberrant Notch signaling results in the development of psoriasis and skin cancers such as squamous cell carcinoma, basal cell carcinoma and malignant melanoma. Future efforts to further define how Notch controls cell proliferation and differentiation may lead to the application of Notch in new therapies for various skin diseases. Ryuhei Okuyama graduated and received the PhD degree from Tohoku University Graduate School of Medicine, Sendai, Japan, in 1995. After that he worked as a dermatologist at the Department of Dermatology, Tohoku University Graduate School of Medicine (Prof. Hachiro Tagami). From 1997 to 2000 he was a postdoctoral fellow at the Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, USA (Prof. G.P. Dotto). In 2000, he returned to Tohoku University (Prof. Setsuya Aiba), and since 2006 he has been an Associate Professor of Dermatology there. His scientific and clinical specialties are: skin cancer, psoriasis, burns, wound healing, connective tissue diseases, and molecular and cellular biology in the skin." @default.
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• W2094197344 date "2008-03-01" @default.
• W2094197344 modified "2023-09-26" @default.
• W2094197344 title "Notch signaling: Its role in epidermal homeostasis and in the pathogenesis of skin diseases" @default.
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• W2094197344 doi "https://doi.org/10.1016/j.jdermsci.2007.05.017" @default.
• W2094197344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17624739" @default.
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