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• W2094198269 abstract "We previously showed that Nuclear Factor kappaB (NF-kappaB) inactivation in astrocytes leads to improved functional recovery following spinal cord injury (SCI). This correlated with reduced expression of pro-inflammatory mediators and chondroitin sulfate proteoglycans, and increased white matter preservation. Hence we hypothesized that inactivation of astrocytic NF-kappaB would create a more permissive environment for axonal sprouting and regeneration. We induced both contusive and complete transection SCI in GFAP-Inhibitor of kappaB-dominant negative (GFAP-IkappaBalpha-dn) and wild-type (WT) mice and performed retrograde [fluorogold (FG)] and anterograde [biotinylated dextran amine (BDA)] tracing 8 weeks after injury. Following contusive SCI, more FG-labeled cells were found in motor cortex, reticular formation, and raphe nuclei of transgenic mice. Spared and sprouting BDA-positive corticospinal axons were found caudal to the lesion in GFAP-IkappaBalpha-dn mice. Higher numbers of FG-labeled neurons were detected immediately rostral to the lesion in GFAP-IkappaBalpha-dn mice, accompanied by increased expression of synaptic and axonal growth-associated molecules. After transection, however, no FG-labeled neurons or BDA-filled axons were found rostral and caudal to the lesion, respectively, in either genotype. These data demonstrated that inhibiting astroglial NF-kappaB resulted in a growth-supporting terrain promoting sparing and sprouting, rather than regeneration, of supraspinal and propriospinal circuitries essential for locomotion, hence contributing to the improved functional recovery observed after SCI in GFAP-IkappaBalpha-dn mice." @default.
• W2094198269 created "2016-06-24" @default.
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• W2094198269 date "2009-07-01" @default.
• W2094198269 modified "2023-10-06" @default.
• W2094198269 title "Transgenic inhibition of astroglial NF-κB leads to increased axonal sparing and sprouting following spinal cord injury" @default.
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• W2094198269 cites W1779982979 @default.
• W2094198269 cites W1813767736 @default.
• W2094198269 cites W1963586813 @default.
• W2094198269 cites W1964947242 @default.
• W2094198269 cites W1966007526 @default.
• W2094198269 cites W1967116517 @default.
• W2094198269 cites W1970476447 @default.
• W2094198269 cites W1970901436 @default.
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• W2094198269 cites W1974319076 @default.
• W2094198269 cites W1979485742 @default.
• W2094198269 cites W1988868629 @default.
• W2094198269 cites W1998052230 @default.
• W2094198269 cites W1999810771 @default.
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• W2094198269 cites W202929248 @default.
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• W2094198269 cites W2030927825 @default.
• W2094198269 cites W2039779226 @default.
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• W2094198269 cites W2042756573 @default.
• W2094198269 cites W2049625461 @default.
• W2094198269 cites W2050526523 @default.
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• W2094198269 doi "https://doi.org/10.1111/j.1471-4159.2009.06190.x" @default.
• W2094198269 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4090052" @default.
• W2094198269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19522780" @default.
• W2094198269 hasPublicationYear "2009" @default.
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