Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094201582> ?p ?o ?g. }
- W2094201582 endingPage "661" @default.
- W2094201582 startingPage "654" @default.
- W2094201582 abstract "Severe aortic stenosis above the renal arteries leads to a reduction in renal perfusion, increased renin secretion, and elevation of arterial blood pressure above the stenotic site. Nitric oxide (NO) plays an important role in regulation of renal and systemic vascular resistance, renal blood flow, and Na(+) handling. Abdominal aortic banding provides an excellent model for simultaneous testing of the effects of increased and decreased pressure, flow, and shear stress in the same animal.We studied protein expressions of endothelial NO synthase (eNOS), inducible NOS (iNOS), and neuroneal NOS (nNOS) isotypes in the renal cortex, renal medulla, heart, brain, and aorta segments above and below the stenosis site three weeks after abdominal aortic banding above the renal arteries. The results were compared with those obtained in the sham-operated controls. NOS isotype proteins were measured by Western blot.Compared with the control group, the banded group showed significant up-regulations of eNOS, iNOS, and nNOS in renal cortex and medulla. Likewise, heart eNOS, brain nNOS, and thoracic aorta eNOS proteins were significantly increased in the banded group. However, eNOS and iNOS expressions were unchanged in the aorta segment below the stenotic site. Likewise, iNOS expression in the heart and thoracic aorta remained unchanged in the banded animals. No significant difference was found in creatinine clearance or urinary protein excretion between the two groups.These findings clearly demonstrate the up-regulatory action of increased pressure on eNOS expression in the thoracic aorta and heart and of nNOS expression in the brain. These data further show up-regulation of all NOS isotypes in the kidney, which must have helped to mitigate the associated hypoperfusion." @default.
- W2094201582 created "2016-06-24" @default.
- W2094201582 creator A5039394237 @default.
- W2094201582 creator A5056238061 @default.
- W2094201582 creator A5073150276 @default.
- W2094201582 date "2001-02-01" @default.
- W2094201582 modified "2023-10-14" @default.
- W2094201582 title "Effect of severe aortic banding above the renal arteries on nitric oxide synthase isotype expression" @default.
- W2094201582 cites W1883906051 @default.
- W2094201582 cites W1966322594 @default.
- W2094201582 cites W1973651651 @default.
- W2094201582 cites W1975896607 @default.
- W2094201582 cites W1986619455 @default.
- W2094201582 cites W1987165240 @default.
- W2094201582 cites W2001766586 @default.
- W2094201582 cites W2002255848 @default.
- W2094201582 cites W2003777560 @default.
- W2094201582 cites W2003912731 @default.
- W2094201582 cites W2024049544 @default.
- W2094201582 cites W2027245641 @default.
- W2094201582 cites W2046265270 @default.
- W2094201582 cites W2048635427 @default.
- W2094201582 cites W2063208027 @default.
- W2094201582 cites W2063267156 @default.
- W2094201582 cites W2068876774 @default.
- W2094201582 cites W2075608865 @default.
- W2094201582 cites W2076977434 @default.
- W2094201582 cites W2080601476 @default.
- W2094201582 cites W2089987432 @default.
- W2094201582 cites W2091220555 @default.
- W2094201582 cites W2097944953 @default.
- W2094201582 cites W2099831786 @default.
- W2094201582 cites W2100854904 @default.
- W2094201582 cites W2109893157 @default.
- W2094201582 cites W2134386806 @default.
- W2094201582 cites W2149405384 @default.
- W2094201582 cites W2149429779 @default.
- W2094201582 cites W2153889396 @default.
- W2094201582 cites W2157701601 @default.
- W2094201582 cites W2161134919 @default.
- W2094201582 cites W2168038844 @default.
- W2094201582 cites W2259482999 @default.
- W2094201582 cites W2339639271 @default.
- W2094201582 cites W2341645956 @default.
- W2094201582 cites W2395967558 @default.
- W2094201582 cites W4318751241 @default.
- W2094201582 doi "https://doi.org/10.1046/j.1523-1755.2001.059002654.x" @default.
- W2094201582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11168947" @default.
- W2094201582 hasPublicationYear "2001" @default.
- W2094201582 type Work @default.
- W2094201582 sameAs 2094201582 @default.
- W2094201582 citedByCount "43" @default.
- W2094201582 countsByYear W20942015822014 @default.
- W2094201582 countsByYear W20942015822015 @default.
- W2094201582 countsByYear W20942015822021 @default.
- W2094201582 crossrefType "journal-article" @default.
- W2094201582 hasAuthorship W2094201582A5039394237 @default.
- W2094201582 hasAuthorship W2094201582A5056238061 @default.
- W2094201582 hasAuthorship W2094201582A5073150276 @default.
- W2094201582 hasBestOaLocation W20942015821 @default.
- W2094201582 hasConcept C126322002 @default.
- W2094201582 hasConcept C134018914 @default.
- W2094201582 hasConcept C142225936 @default.
- W2094201582 hasConcept C164705383 @default.
- W2094201582 hasConcept C2776634560 @default.
- W2094201582 hasConcept C2776864027 @default.
- W2094201582 hasConcept C2777622882 @default.
- W2094201582 hasConcept C2778326061 @default.
- W2094201582 hasConcept C2779980429 @default.
- W2094201582 hasConcept C2780091579 @default.
- W2094201582 hasConcept C2780512574 @default.
- W2094201582 hasConcept C2780520971 @default.
- W2094201582 hasConcept C2781243531 @default.
- W2094201582 hasConcept C2909028682 @default.
- W2094201582 hasConcept C519581460 @default.
- W2094201582 hasConcept C71924100 @default.
- W2094201582 hasConceptScore W2094201582C126322002 @default.
- W2094201582 hasConceptScore W2094201582C134018914 @default.
- W2094201582 hasConceptScore W2094201582C142225936 @default.
- W2094201582 hasConceptScore W2094201582C164705383 @default.
- W2094201582 hasConceptScore W2094201582C2776634560 @default.
- W2094201582 hasConceptScore W2094201582C2776864027 @default.
- W2094201582 hasConceptScore W2094201582C2777622882 @default.
- W2094201582 hasConceptScore W2094201582C2778326061 @default.
- W2094201582 hasConceptScore W2094201582C2779980429 @default.
- W2094201582 hasConceptScore W2094201582C2780091579 @default.
- W2094201582 hasConceptScore W2094201582C2780512574 @default.
- W2094201582 hasConceptScore W2094201582C2780520971 @default.
- W2094201582 hasConceptScore W2094201582C2781243531 @default.
- W2094201582 hasConceptScore W2094201582C2909028682 @default.
- W2094201582 hasConceptScore W2094201582C519581460 @default.
- W2094201582 hasConceptScore W2094201582C71924100 @default.
- W2094201582 hasIssue "2" @default.
- W2094201582 hasLocation W20942015821 @default.
- W2094201582 hasLocation W20942015822 @default.
- W2094201582 hasOpenAccess W2094201582 @default.
- W2094201582 hasPrimaryLocation W20942015821 @default.
- W2094201582 hasRelatedWork W189824070 @default.