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- W2094207931 abstract "The capital role of nuclear glutathione in the control of cell physiology has been demonstrated in the last years. Here we provide preliminary reports showing that the role of glutathione in the control of important cellular function is partially due to the modification of several epigenetics factors. These changes have been described in a number of physiopathological processes. We will show that carbonylation of histones is decreased in plasma samples from centenarians when compared with young volunteers. Suggesting that carbonylation of histones is a marker for the degradation of histones. The pattern of carbonylation for the different histone isoforms will be described. Results correlate with Poly ADPribosylation. The lysil oxidase activity could be responsible of this action. These changes correlate with acetylation and methylation changes of different lysine residues in histones of lymphocytes from old volunteers. Using an in vitro model, NIH3T3 fibroblasts, we studied the dynamic changes of carbonylation and poly(ADPribosylation of histones during different times of cell culture. When cell proliferate carbonylation of histones increases. In addition, histone carbonylation decreases after nuclear proteasome activation, indicating that histone carbonylation may be a redox epigenetic mark to prevent the fatal event of histone accumulation. An important number of rare diseases are due to chromosomal instability and DNA damage. Many of these diseases have oxidative stress. We will provide information of the changes in PARP activity and DNA repair and the correlation with changes in the antioxidant machinery using fibroblasts from rare disease patients." @default.
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- W2094207931 date "2012-09-01" @default.
- W2094207931 modified "2023-09-27" @default.
- W2094207931 title "Nuclear glutathione and the cell cycle in plants" @default.
- W2094207931 doi "https://doi.org/10.1016/j.freeradbiomed.2012.08.141" @default.
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