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- W2094209212 abstract "The possible involvement of adrenergic mechanisms in regulating the secretion of growth hormone (GH)-releasing factor (GRF) from the rat hypothalamus was examined in vitro with a perifusion system. A high potassium concentration (56 mM) stimulated GRF release from the hypothalamus. The infusion of clonidine (10(-4) M), an alpha 2-adrenergic stimulant, resulted in an increase in the spontaneous release of GRF. In the presence of propranolol (10(-5) M), a beta-adrenergic blocking agent, clonidine (10(-5) and 10(-4) M) stimulated GRF release more prominently in a dose-related manner, whereas propranolol (10(-5) and 10(-4) M) by itself did not affect the spontaneous GRF release. The stimulatory effect of clonidine (10(-4) M) on GRF release in the presence of propranolol was inhibited by yohimbine (10(-4) M), an alpha 2-adrenergic blocking agent. These findings suggest that alpha 2-adrenergic mechanisms play a role in stimulating GRF release from the hypothalamus in rats." @default.
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- W2094209212 date "1986-07-01" @default.
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- W2094209212 title "STIMULATION BY ALPHA-ADRENERGIC MECHANISMS OF THE SECRETION OF GROWTH HORMONE-RELEASING FACTOR (GRF) FROM PERIFUSED RAT HYPOTHALAMUS" @default.
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- W2094209212 doi "https://doi.org/10.1210/endo-119-1-432" @default.
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