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- W2094209540 endingPage "595" @default.
- W2094209540 startingPage "585" @default.
- W2094209540 abstract "For many viruses, assembly and budding occur simultaneously during virion formation. Understanding the mechanisms underlying this process could promote biomedical efforts to block viral propagation and enable use of capsids in nanomaterials applications. To this end, we have performed molecular dynamics simulations on a coarse-grained model that describes virus assembly on a fluctuating lipid membrane. Our simulations show that the membrane can promote association of adsorbed subunits through dimensional reduction, but it also introduces thermodynamic and kinetic effects that can inhibit complete assembly. We find several mechanisms by which membrane microdomains, such as lipid rafts, reduce these effects, and thus, enhance assembly. We show how these predicted mechanisms can be experimentally tested. Furthermore, the simulations demonstrate that assembly and budding depend crucially on the system dynamics via multiple timescales related to membrane deformation, protein diffusion, association, and adsorption onto the membrane." @default.
- W2094209540 created "2016-06-24" @default.
- W2094209540 creator A5040956168 @default.
- W2094209540 creator A5083616699 @default.
- W2094209540 date "2015-02-01" @default.
- W2094209540 modified "2023-10-02" @default.
- W2094209540 title "Simulations Show that Virus Assembly and Budding Are Facilitated by Membrane Microdomains" @default.
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