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- W2094216819 abstract "The present study evaluated the effects of thimerosal, a vaccine preservative, on cytosolic free Ca2+ concentrations ([Ca2+]i) in human prostate cancer cells (PC3). Thimerosal (10–200 µM) increased [Ca2+]i in a concentration-dependent manner. The Ca2+ signal was reduced partly by removing extracellular Ca2+. Thimerosal-induced Ca2+ influx was inhibited by econazole, SKF963656, the phospholipase A2 inhibitor aristolochic acid, and protein kinase C modulators [phorbol 12-myristate 13-acetate (PMA) and GF109203X]. In Ca2+-free medium, a 200-µM thimerosal-induced [Ca2+]i rise was partly inhibited after pretreatment with 2,5-di-tert-butylhydroquinone (BHQ) (an endoplasmic reticulum Ca2+ pump inhibitor). Thimerosal at 1–7 µM induced cell death in a concentration-dependent manner that was not reversed when cytosolic Ca2+ was chelated with 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (BAPTA). Propidium iodide staining suggests that apoptosis played a role in the death. Collectively, in PC3 cells, thimerosal induced [Ca2+]i rise by causing Ca2+ release from the endoplasmic reticulum and Ca2+ influx via store-operated Ca2+ channels in a manner regulated by protein kinase C and phospholipase A2. Thimerosal also induced cell death in a Ca2+-independent apoptotic manner. Drug Dev Res 72: 330–336, 2011. © 2011 Wiley-Liss, Inc." @default.
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- W2094216819 date "2011-03-09" @default.
- W2094216819 modified "2023-09-25" @default.
- W2094216819 title "Effect of thimerosal on Ca2+ movement and apoptosis in PC3 prostate cancer cells" @default.
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- W2094216819 doi "https://doi.org/10.1002/ddr.20434" @default.
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