FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094238617> ?p ?o ?g. }

• W2094238617 endingPage "1423" @default.
• W2094238617 startingPage "1416" @default.
• W2094238617 abstract "Objectives: Cholinergic projections to cerebral cortical and subcortical regions are decreased in Parkinson disease (PD), but not evaluated in the parkinsonian syndromes of multiple system atrophy (MSA-P) and progressive supranuclear palsy (PSP). We studied cholinergic innervation in these disorders as compared to age-appropriate normal control subjects. Methods: We used PET with [ 11 C]PMP to measure acetylcholinesterase (AChE) activity in multiple cerebral cortical and subcortical regions. We studied 22 normal controls, 12 patients with PD, 13 patients with MSA-P, and 4 patients with PSP. Results: We found significantly decreased AChE activity in most cerebral cortical regions in PD and MSA-P, and a similar but nonsignificant decrease in PSP. No differences were found between PD and MSA-P. Significantly decreased AChE activity was found in PD in striatum, cerebellum, and thalamus, with a marginally significant decrease in mesencephalon and no change in pons. Significantly greater declines in AChE activity in all subcortical regions were seen in MSA-P and PSP vs in PD. Decreased AChE activity in brainstem and cerebellum of all 3 disorders correlated with disturbances of balance and gait. Conclusions: Cerebral cortical cholinergic activity is decreased to a similar level in Parkinson disease (PD), parkinsonian syndromes of multiple system atrophy (MSA-P), and progressive supranuclear palsy (PSP) as compared to normal controls. Subcortical cholinergic activity is significantly more decreased in MSA-P and PSP than in PD. The more substantial decrease reflects greater impairment in the pontine cholinergic group, which is important in motor activity, particularly gait. These differences may account for the greater gait disturbances in the early stages of MSA-P and PSP than in PD." @default.
• W2094238617 created "2016-06-24" @default.
• W2094238617 creator A5002998745 @default.
• W2094238617 creator A5009800657 @default.
• W2094238617 creator A5016361796 @default.
• W2094238617 creator A5026885325 @default.
• W2094238617 creator A5032373120 @default.
• W2094238617 creator A5034370633 @default.
• W2094238617 creator A5070014519 @default.
• W2094238617 creator A5083886913 @default.
• W2094238617 creator A5091584382 @default.
• W2094238617 date "2010-05-03" @default.
• W2094238617 modified "2023-09-25" @default.
• W2094238617 title "Cerebral cortical and subcortical cholinergic deficits in parkinsonian syndromes" @default.
• W2094238617 cites W1923741810 @default.
• W2094238617 cites W1966684691 @default.
• W2094238617 cites W1971579987 @default.
• W2094238617 cites W1981488967 @default.
• W2094238617 cites W1985908228 @default.
• W2094238617 cites W1986283880 @default.
• W2094238617 cites W1997004893 @default.
• W2094238617 cites W2003471045 @default.
• W2094238617 cites W2008827081 @default.
• W2094238617 cites W2009021103 @default.
• W2094238617 cites W2009804051 @default.
• W2094238617 cites W2020232311 @default.
• W2094238617 cites W2020279062 @default.
• W2094238617 cites W2021280501 @default.
• W2094238617 cites W2033523068 @default.
• W2094238617 cites W2034046047 @default.
• W2094238617 cites W2042431851 @default.
• W2094238617 cites W2047038935 @default.
• W2094238617 cites W2048755200 @default.
• W2094238617 cites W2065727812 @default.
• W2094238617 cites W2074682417 @default.
• W2094238617 cites W2078603523 @default.
• W2094238617 cites W2085594747 @default.
• W2094238617 cites W2086822708 @default.
• W2094238617 cites W2087485448 @default.
• W2094238617 cites W2089017290 @default.
• W2094238617 cites W2093330582 @default.
• W2094238617 cites W2093613378 @default.
• W2094238617 cites W2107251479 @default.
• W2094238617 cites W2136557657 @default.
• W2094238617 cites W2144623340 @default.
• W2094238617 cites W2151885529 @default.
• W2094238617 cites W2155299862 @default.
• W2094238617 cites W77026836 @default.
• W2094238617 doi "https://doi.org/10.1212/wnl.0b013e3181dc1a55" @default.
• W2094238617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2871002" @default.
• W2094238617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20439843" @default.
• W2094238617 hasPublicationYear "2010" @default.
• W2094238617 type Work @default.
• W2094238617 sameAs 2094238617 @default.
• W2094238617 citedByCount "131" @default.
• W2094238617 countsByYear W20942386172012 @default.
• W2094238617 countsByYear W20942386172013 @default.
• W2094238617 countsByYear W20942386172014 @default.
• W2094238617 countsByYear W20942386172015 @default.
• W2094238617 countsByYear W20942386172016 @default.
• W2094238617 countsByYear W20942386172017 @default.
• W2094238617 countsByYear W20942386172018 @default.
• W2094238617 countsByYear W20942386172019 @default.
• W2094238617 countsByYear W20942386172020 @default.
• W2094238617 countsByYear W20942386172021 @default.
• W2094238617 countsByYear W20942386172022 @default.
• W2094238617 countsByYear W20942386172023 @default.
• W2094238617 crossrefType "journal-article" @default.
• W2094238617 hasAuthorship W2094238617A5002998745 @default.
• W2094238617 hasAuthorship W2094238617A5009800657 @default.
• W2094238617 hasAuthorship W2094238617A5016361796 @default.
• W2094238617 hasAuthorship W2094238617A5026885325 @default.
• W2094238617 hasAuthorship W2094238617A5032373120 @default.
• W2094238617 hasAuthorship W2094238617A5034370633 @default.
• W2094238617 hasAuthorship W2094238617A5070014519 @default.
• W2094238617 hasAuthorship W2094238617A5083886913 @default.
• W2094238617 hasAuthorship W2094238617A5091584382 @default.
• W2094238617 hasBestOaLocation W20942386172 @default.
• W2094238617 hasConcept C126322002 @default.
• W2094238617 hasConcept C134018914 @default.
• W2094238617 hasConcept C15744967 @default.
• W2094238617 hasConcept C169760540 @default.
• W2094238617 hasConcept C181199279 @default.
• W2094238617 hasConcept C22885893 @default.
• W2094238617 hasConcept C2776477761 @default.
• W2094238617 hasConcept C2778816929 @default.
• W2094238617 hasConcept C2778897929 @default.
• W2094238617 hasConcept C2779134260 @default.
• W2094238617 hasConcept C2779246727 @default.
• W2094238617 hasConcept C2779652256 @default.
• W2094238617 hasConcept C2779734285 @default.
• W2094238617 hasConcept C2780062018 @default.
• W2094238617 hasConcept C2781041448 @default.
• W2094238617 hasConcept C2781172350 @default.
• W2094238617 hasConcept C513476851 @default.
• W2094238617 hasConcept C551621295 @default.
• W2094238617 hasConcept C55493867 @default.
• W2094238617 hasConcept C71924100 @default.

• next