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• W2094250024 abstract "When muscle fibres isolated from the frog's semitendinosus are placed in a calcium-free, bicarbonate buffered Ringer's solution the twitch declines in an irregular stepwise fashion and disappears usually within 1 to 9 min. There is often an initial period of twitch potentiation when the fibres are exposed to 0-Ca2+. Although considerably shorter than the time in 0-Ca2+ required to deplete intracellular calcium stores, the time required to eliminate the twitch is longer than estimates of the minimum time required to remove calcium from the fluid in the t-tubular network by free diffusion. When the calcium concentration was only partially reduced the twitch was potentiated at concentrations between 10 and 50% of the usual concentration in Ringer's. At lower calcium concentrations the potentiation is followed by a reduction, and in some fibres the twitch was eliminated without completely removing the calcium ions from the bathing solution. The results support the hypothesis that there is a store of calcium ions bound to the t-tubular membranes (trigger calcium) which is required for excitation-contraction coupling during the twitch." @default.
• W2094250024 created "2016-06-24" @default.
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• W2094250024 date "1982-01-01" @default.
• W2094250024 modified "2023-09-25" @default.
• W2094250024 title "The effects of reducing the extracellular calcium concentration on the twitch in isolated frog's skeletal muscle fibres." @default.
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• W2094250024 doi "https://doi.org/10.2170/jjphysiol.32.589" @default.
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