FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094262605> ?p ?o ?g. }

• W2094262605 endingPage "1663" @default.
• W2094262605 startingPage "1656" @default.
• W2094262605 abstract "Mutations in fibroblast growth factor 23 (FGF-23) cause autosomal dominant hypophosphatemic rickets. Clinical and laboratory findings in this disorder are similar to those in oncogenic osteomalacia, in which tumors abundantly express FGF-23 messenger RNA, and to those in X-linked hypophosphatemia, which is caused by inactivating mutations in a phosphate-regulating endopeptidase called PHEX. Recombinant FGF-23 induces phosphaturia and hypophosphatemia in vivo, suggesting that it has a role in phosphate regulation. To determine whether FGF-23 circulates in healthy persons and whether it is elevated in those with oncogenic osteomalacia or X-linked hypophosphatemia, an immunometric assay was developed to measure it.Using affinity-purified, polyclonal antibodies against [Tyr223]FGF-23(206-222)amide and [Tyr224]FGF-23(225-244)amide, we developed a two-site enzyme-linked immunosorbent assay that detects equivalently recombinant human FGF-23, the mutant form in which glutamine is substituted for arginine at position 179 (R179Q), and synthetic human FGF-23(207-244)amide. Plasma or serum samples from 147 healthy adults (mean [+/-SD] age, 48.4+/-19.6 years) and 26 healthy children (mean age, 10.9+/-5.5 years) and from 17 patients with oncogenic osteomalacia (mean age, 43.0+/-13.3 years) and 21 patients with X-linked hypophosphatemia (mean age, 34.9+/-17.2 years) were studied.Mean FGF-23 concentrations in the healthy adults and children were 55+/-50 and 69+/-36 reference units (RU) per milliliter, respectively. Four patients with oncogenic osteomalacia had concentrations ranging from 426 to 7970 RU per milliliter, which normalized after tumor resection. FGF-23 concentrations were 481+/-528 RU per milliliter in those with suspected oncogenic osteomalacia and 353+/-510 RU per milliliter (range, 31 to 2335) in those with X-linked hypophosphatemia.FGF-23 is readily detectable in the plasma or serum of healthy persons and can be markedly elevated in those with oncogenic osteomalacia or X-linked hypophosphatemia, suggesting that this growth factor has a role in phosphate homeostasis. FGF-23 measurements might improve the management of phosphate-wasting disorders." @default.
• W2094262605 created "2016-06-24" @default.
• W2094262605 creator A5000844351 @default.
• W2094262605 creator A5001526094 @default.
• W2094262605 creator A5004405514 @default.
• W2094262605 creator A5004478129 @default.
• W2094262605 creator A5011066885 @default.
• W2094262605 creator A5019107478 @default.
• W2094262605 creator A5025555546 @default.
• W2094262605 creator A5031267390 @default.
• W2094262605 creator A5037643206 @default.
• W2094262605 creator A5049647988 @default.
• W2094262605 creator A5052702193 @default.
• W2094262605 creator A5061211092 @default.
• W2094262605 creator A5062703256 @default.
• W2094262605 creator A5065254316 @default.
• W2094262605 creator A5075515448 @default.
• W2094262605 creator A5086367634 @default.
• W2094262605 date "2003-04-24" @default.
• W2094262605 modified "2023-10-17" @default.
• W2094262605 title "Fibroblast Growth Factor 23 in Oncogenic Osteomalacia and X-Linked Hypophosphatemia" @default.
• W2094262605 cites W1563425273 @default.
• W2094262605 cites W1970305413 @default.
• W2094262605 cites W2045129957 @default.
• W2094262605 cites W2063765502 @default.
• W2094262605 cites W2068226571 @default.
• W2094262605 cites W2106503825 @default.
• W2094262605 cites W2134792323 @default.
• W2094262605 cites W2136483324 @default.
• W2094262605 cites W2170351820 @default.
• W2094262605 cites W2396989700 @default.
• W2094262605 cites W4252531423 @default.
• W2094262605 cites W4256049800 @default.
• W2094262605 doi "https://doi.org/10.1056/nejmoa020881" @default.
• W2094262605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12711740" @default.
• W2094262605 hasPublicationYear "2003" @default.
• W2094262605 type Work @default.
• W2094262605 sameAs 2094262605 @default.
• W2094262605 citedByCount "830" @default.
• W2094262605 countsByYear W20942626052012 @default.
• W2094262605 countsByYear W20942626052013 @default.
• W2094262605 countsByYear W20942626052014 @default.
• W2094262605 countsByYear W20942626052015 @default.
• W2094262605 countsByYear W20942626052016 @default.
• W2094262605 countsByYear W20942626052017 @default.
• W2094262605 countsByYear W20942626052018 @default.
• W2094262605 countsByYear W20942626052019 @default.
• W2094262605 countsByYear W20942626052020 @default.
• W2094262605 countsByYear W20942626052021 @default.
• W2094262605 countsByYear W20942626052022 @default.
• W2094262605 countsByYear W20942626052023 @default.
• W2094262605 crossrefType "journal-article" @default.
• W2094262605 hasAuthorship W2094262605A5000844351 @default.
• W2094262605 hasAuthorship W2094262605A5001526094 @default.
• W2094262605 hasAuthorship W2094262605A5004405514 @default.
• W2094262605 hasAuthorship W2094262605A5004478129 @default.
• W2094262605 hasAuthorship W2094262605A5011066885 @default.
• W2094262605 hasAuthorship W2094262605A5019107478 @default.
• W2094262605 hasAuthorship W2094262605A5025555546 @default.
• W2094262605 hasAuthorship W2094262605A5031267390 @default.
• W2094262605 hasAuthorship W2094262605A5037643206 @default.
• W2094262605 hasAuthorship W2094262605A5049647988 @default.
• W2094262605 hasAuthorship W2094262605A5052702193 @default.
• W2094262605 hasAuthorship W2094262605A5061211092 @default.
• W2094262605 hasAuthorship W2094262605A5062703256 @default.
• W2094262605 hasAuthorship W2094262605A5065254316 @default.
• W2094262605 hasAuthorship W2094262605A5075515448 @default.
• W2094262605 hasAuthorship W2094262605A5086367634 @default.
• W2094262605 hasBestOaLocation W20942626051 @default.
• W2094262605 hasConcept C114276007 @default.
• W2094262605 hasConcept C124490489 @default.
• W2094262605 hasConcept C126322002 @default.
• W2094262605 hasConcept C134018914 @default.
• W2094262605 hasConcept C2776338720 @default.
• W2094262605 hasConcept C2776489590 @default.
• W2094262605 hasConcept C2778049618 @default.
• W2094262605 hasConcept C2778573388 @default.
• W2094262605 hasConcept C2781208988 @default.
• W2094262605 hasConcept C519063684 @default.
• W2094262605 hasConcept C71924100 @default.
• W2094262605 hasConceptScore W2094262605C114276007 @default.
• W2094262605 hasConceptScore W2094262605C124490489 @default.
• W2094262605 hasConceptScore W2094262605C126322002 @default.
• W2094262605 hasConceptScore W2094262605C134018914 @default.
• W2094262605 hasConceptScore W2094262605C2776338720 @default.
• W2094262605 hasConceptScore W2094262605C2776489590 @default.
• W2094262605 hasConceptScore W2094262605C2778049618 @default.
• W2094262605 hasConceptScore W2094262605C2778573388 @default.
• W2094262605 hasConceptScore W2094262605C2781208988 @default.
• W2094262605 hasConceptScore W2094262605C519063684 @default.
• W2094262605 hasConceptScore W2094262605C71924100 @default.
• W2094262605 hasIssue "17" @default.
• W2094262605 hasLocation W20942626051 @default.
• W2094262605 hasLocation W20942626052 @default.
• W2094262605 hasOpenAccess W2094262605 @default.
• W2094262605 hasPrimaryLocation W20942626051 @default.
• W2094262605 hasRelatedWork W1564099730 @default.
• W2094262605 hasRelatedWork W2095116545 @default.

• next