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- W2094263092 abstract "In this work, a series of 10 structural procaine analogs have been synthesized in order to investigate the structural features affecting the stability of ion pair formation and its influence on the lipophilicity of ionizable compounds. The structural variation within this series was focused on the terminal nitrogen substituents and on the intermediate chain linkage nature. The hydrophobic parameters logP(n) and logP(i) (partition coefficient of the neutral and ionic species, respectively), as well as the ionization constants pK(a) and pK(a)(oct), were obtained from logD-pH profiles measured at pH values ranging from 2 to 12. The difference between logP(i) and logP(n) values (i.e. difflogP) of each prepared compound was considered a measure of the stability of ion pair formation. In this set, the difflogP values varied nearly over one log unit, ranging from -2.40 to -3.37. It has been observed that the presence of hydrogen bonding groups (especially donor) and low steric hindrance around the terminal amine ionizable group increases the relative lipophilicity of the ionic species as compared to the corresponding neutral species. These results were interpreted as due to the increased stability of ion pairs of the compounds bearing these structural features." @default.
- W2094263092 created "2016-06-24" @default.
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- W2094263092 date "2010-12-01" @default.
- W2094263092 modified "2023-09-23" @default.
- W2094263092 title "Ion pair stabilization effects on a series of procaine structural analogs" @default.
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- W2094263092 doi "https://doi.org/10.1016/j.ejps.2010.09.003" @default.
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