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- W2094267811 endingPage "033101" @default.
- W2094267811 startingPage "033101" @default.
- W2094267811 abstract "In eukaryotes, the genome is packed into chromosomes, each consisting of large polymeric fibers made of DNA bound with proteins (mainly histones) and RNA molecules. The nature and precise 3D organization of this fiber has been a matter of intense speculations and debates. In the emerging picture, the local chromatin state plays a critical role in all fundamental DNA transactions, such as transcriptional control, DNA replication or repair. However, the molecular and structural mechanisms involved remain elusive. The purpose of this review is to give an overview of the tremendous efforts that have been made for almost 40 years to build physiologically relevant models of chromatin structure. The motivation behind building such models was to shift our representation and understanding of DNA transactions from a too simplistic 'naked DNA' view to a more realistic 'coated DNA' view, as a step towards a better framework in which to interpret mechanistically the control of genetic expression and other DNA metabolic processes. The field has evolved from a speculative point of view towards in vitro biochemistry and in silico modeling, but is still longing for experimental in vivo validations of the proposed structures or even proof of concept experiments demonstrating a clear role of a given structure in a metabolic transaction. The mere existence of a chromatin fiber as a relevant biological entity in vivo has been put into serious questioning. Current research is suggesting a possible reconciliation between theoretical studies and experiments, pointing towards a view where the polymorphic and dynamic nature of the chromatin fiber is essential to support its function in genome metabolism." @default.
- W2094267811 created "2016-06-24" @default.
- W2094267811 creator A5025770177 @default.
- W2094267811 creator A5027346778 @default.
- W2094267811 creator A5067936176 @default.
- W2094267811 date "2014-12-01" @default.
- W2094267811 modified "2023-10-16" @default.
- W2094267811 title "The polymorphisms of the chromatin fiber" @default.
- W2094267811 cites W1585671632 @default.
- W2094267811 cites W1596356932 @default.
- W2094267811 cites W1693372251 @default.
- W2094267811 cites W1927250746 @default.
- W2094267811 cites W1929242319 @default.
- W2094267811 cites W1963491706 @default.
- W2094267811 cites W1963835418 @default.
- W2094267811 cites W1967560809 @default.
- W2094267811 cites W1967631673 @default.
- W2094267811 cites W1968894421 @default.
- W2094267811 cites W1973771110 @default.
- W2094267811 cites W1974292158 @default.
- W2094267811 cites W1975135992 @default.
- W2094267811 cites W1975191033 @default.
- W2094267811 cites W1976206664 @default.
- W2094267811 cites W1976280587 @default.
- W2094267811 cites W1977760022 @default.
- W2094267811 cites W1978107331 @default.
- W2094267811 cites W1980153321 @default.
- W2094267811 cites W1981033633 @default.
- W2094267811 cites W1981037598 @default.
- W2094267811 cites W1983159345 @default.
- W2094267811 cites W1983369082 @default.
- W2094267811 cites W1988997227 @default.
- W2094267811 cites W1990268713 @default.
- W2094267811 cites W1993822465 @default.
- W2094267811 cites W1996106014 @default.
- W2094267811 cites W1997896590 @default.
- W2094267811 cites W2001616038 @default.
- W2094267811 cites W2001929989 @default.
- W2094267811 cites W2002197756 @default.
- W2094267811 cites W2002718343 @default.
- W2094267811 cites W2003266654 @default.
- W2094267811 cites W2003569868 @default.
- W2094267811 cites W2004694336 @default.
- W2094267811 cites W2004791897 @default.
- W2094267811 cites W2005282195 @default.
- W2094267811 cites W2012525958 @default.
- W2094267811 cites W2013571070 @default.
- W2094267811 cites W2013656803 @default.
- W2094267811 cites W2016183391 @default.
- W2094267811 cites W2016554962 @default.
- W2094267811 cites W2017314177 @default.
- W2094267811 cites W2018626566 @default.
- W2094267811 cites W2020285079 @default.
- W2094267811 cites W2023621898 @default.
- W2094267811 cites W2024224240 @default.
- W2094267811 cites W2029873987 @default.
- W2094267811 cites W2029931866 @default.
- W2094267811 cites W2030023744 @default.
- W2094267811 cites W2030905174 @default.
- W2094267811 cites W2033725633 @default.
- W2094267811 cites W2034340491 @default.
- W2094267811 cites W2037121171 @default.
- W2094267811 cites W2038132544 @default.
- W2094267811 cites W2040048585 @default.
- W2094267811 cites W2040109903 @default.
- W2094267811 cites W2043379799 @default.
- W2094267811 cites W2044825578 @default.
- W2094267811 cites W2050445493 @default.
- W2094267811 cites W2050830515 @default.
- W2094267811 cites W2051277445 @default.
- W2094267811 cites W2052842503 @default.
- W2094267811 cites W2054669424 @default.
- W2094267811 cites W2056276733 @default.
- W2094267811 cites W2059477887 @default.
- W2094267811 cites W2059777793 @default.
- W2094267811 cites W2060058004 @default.
- W2094267811 cites W2062728251 @default.
- W2094267811 cites W2063031607 @default.
- W2094267811 cites W2065571115 @default.
- W2094267811 cites W2066715102 @default.
- W2094267811 cites W2066774009 @default.
- W2094267811 cites W2069536617 @default.
- W2094267811 cites W2070224244 @default.
- W2094267811 cites W2074201030 @default.
- W2094267811 cites W2075167717 @default.
- W2094267811 cites W2079973370 @default.
- W2094267811 cites W2080172907 @default.
- W2094267811 cites W2080641060 @default.
- W2094267811 cites W2081127803 @default.
- W2094267811 cites W2082123987 @default.
- W2094267811 cites W2084765876 @default.
- W2094267811 cites W2085458595 @default.
- W2094267811 cites W2087932896 @default.
- W2094267811 cites W2093351957 @default.
- W2094267811 cites W2096194364 @default.
- W2094267811 cites W2099114692 @default.
- W2094267811 cites W2100581810 @default.
- W2094267811 cites W2104939587 @default.