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• W2094275732 abstract "Purpose To compare 3 different treatment positions in whole breast radiation therapy in terms of target volume coverage and doses to the organs at risk (OAR). Methods and Materials Thirty-four breast cancer (BC) patients (17 right-sided and 17 left-sided) were included in this dosimetric planning study. They all underwent a computed tomography (CT) scan in standard supine position in free-breathing (FB), supine position with gating in deep inspiratory breath hold (DIBH)(G), and prone position (P). Three-dimensional treatment plans were made for all 3 CTs. Target coverage and OAR sparing were evaluated. Results Breast volumes varied between 209 and 2814 cm3. The target coverage, expressed as the mean volume of the breast receiving at least 95% of the prescription dose, was similar for the 3 treatment positions. The mean lung dose and the volume of the lungs receiving >20 Gy were significantly lower in P (1.7 Gy; 2.3%) compared with G (3.4 Gy; 5.6%; P < .0001) and FB (4 Gy; 7.3%; P < .0001). The volume of the contralateral breast receiving >5 Gy was significantly lower in G (P = .001) or FB (P = .004) versus prone. The supine position with gating in DIBH significantly reduced the volume of the heart receiving >30 Gy (V30heart), the mean heart (Dheart), and mean left anterior descending coronary artery (LAD) dose (DLAD) for left-sided BC patients (V30heart 0.9%, Dheart 1.6 Gy, DLAD 22.4 Gy) with respect to FB (V30heart 4.3%, Dheart 3.5 Gy, DLAD 30.9 Gy)(V30heart and mean Dheart: P ≤ .0001; mean DLAD: P = .008) and P (V30heart 7.9%, Dheart 5.4 Gy, DLAD 36.4 Gy)(V30heart and mean Dheart: P = .0004; mean DLAD: P = .01). Conclusions The coverage of the planning target volume breast was equal for the 3 treatment positions. The lowest doses to the lungs were achieved in prone. The heart, LAD, and contralateral breast were best spared in the supine position with gating in DIBH." @default.
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• W2094275732 date "2014-03-01" @default.
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• W2094275732 title "Breathing adapted radiation therapy in comparison with prone position to reduce the doses to the heart, left anterior descending coronary artery, and contralateral breast in whole breast radiation therapy" @default.
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• W2094275732 doi "https://doi.org/10.1016/j.prro.2013.07.005" @default.
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