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• W2094279898 abstract "To determine whether the chloride channel protein CLC-3 is upregulated in patients with allergic rhinitis (AR) and whether topical corticosteroid treatment decreases the expression of CLC-3.Histologic study.Academic research.Eighteen patients with AR were included in the study.Expression of CLC-3 was detected by immunohistochemistry and by reverse transcription-polymerase chain reaction before and at 4 weeks after treatment with the topical corticosteroid mometasone furoate.Strong CLC-3 expression was detected in epithelium and in submucosal glands. An increased presence of CLC-3 was demonstrated in nasal mucosa compared with that in normal nasal tissue. A statistically significant difference in CLC-3 gene expression level was found in nasal tissues before vs at 4 weeks after treatment with mometasone.CLC-3 may have a role in modulating the pathogenesis of AR. Decreased expression of CLC-3 may be the mechanism of action of corticosteroid treatment in controlling AR." @default.
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• W2094279898 date "2008-03-01" @default.
• W2094279898 modified "2023-10-16" @default.
• W2094279898 title "Expression of Chloride Channel Protein CLC-3 in Patients With Allergic Rhinitis" @default.
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• W2094279898 doi "https://doi.org/10.1001/archoto.2007.45" @default.
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