Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094283175> ?p ?o ?g. }
- W2094283175 endingPage "1161" @default.
- W2094283175 startingPage "1145" @default.
- W2094283175 abstract "Truncated tau protein at Asp(421) is associated with neurofibrillary pathology in Alzheimer disease (AD); however, little is known about its presence in the form of nonfibrillary aggregates. Here, we report immunohistochemical staining of the Tau-C3 antibody, which recognizes Asp(421)-truncated tau, in a group of AD cases with different extents of cognitive impairment. In the hippocampus, we found distinct nonfibrillary aggregates of Asp(421)-truncated tau. Unlike Asp(421)-composed neurofibrillary tangles, however, these nonfibrillary pathologies did not increase significantly with respect to the Braak staging and, therefore, make no significant contribution to cognitive impairment. On the other hand, despite in vitro evidence that caspase-3 cleaves monomeric tau at Asp(421), to date, this truncation has not been demonstrated to be executed by this protease in polymeric tau entities. We determined that Asp(421) truncation can be produced by caspase-3 in oligomeric and multimeric complexes of recombinant full-length tau in isolated native tau filaments in vitro and in situ in neurofibrillary tangles analyzed in fresh brain slices from AD cases. Our data suggest that generation of this pathologic Asp(421) truncation of tau in long-lasting fibrillary structures may produce further permanent toxicity for neurons in the brains of patients with AD." @default.
- W2094283175 created "2016-06-24" @default.
- W2094283175 creator A5002037496 @default.
- W2094283175 creator A5012489837 @default.
- W2094283175 creator A5016149769 @default.
- W2094283175 creator A5031873973 @default.
- W2094283175 creator A5034670267 @default.
- W2094283175 creator A5041498492 @default.
- W2094283175 creator A5062529967 @default.
- W2094283175 creator A5085648694 @default.
- W2094283175 date "2013-12-01" @default.
- W2094283175 modified "2023-10-18" @default.
- W2094283175 title "Proteolytic Cleavage of Polymeric Tau Protein by Caspase-3: Implications for Alzheimer Disease" @default.
- W2094283175 cites W1500435375 @default.
- W2094283175 cites W1501799002 @default.
- W2094283175 cites W1529133753 @default.
- W2094283175 cites W1586569063 @default.
- W2094283175 cites W1656503843 @default.
- W2094283175 cites W1664805792 @default.
- W2094283175 cites W1675881254 @default.
- W2094283175 cites W1806182908 @default.
- W2094283175 cites W1863182174 @default.
- W2094283175 cites W1893669995 @default.
- W2094283175 cites W1965302577 @default.
- W2094283175 cites W1965709917 @default.
- W2094283175 cites W1966614543 @default.
- W2094283175 cites W1973997858 @default.
- W2094283175 cites W1977002082 @default.
- W2094283175 cites W1981105329 @default.
- W2094283175 cites W1981127983 @default.
- W2094283175 cites W1985351513 @default.
- W2094283175 cites W1986711635 @default.
- W2094283175 cites W1988147472 @default.
- W2094283175 cites W1993023011 @default.
- W2094283175 cites W1994539511 @default.
- W2094283175 cites W1995515835 @default.
- W2094283175 cites W1997426613 @default.
- W2094283175 cites W1998626820 @default.
- W2094283175 cites W2003377906 @default.
- W2094283175 cites W2011246846 @default.
- W2094283175 cites W2012076369 @default.
- W2094283175 cites W2016758992 @default.
- W2094283175 cites W2018908557 @default.
- W2094283175 cites W2021017365 @default.
- W2094283175 cites W2021753155 @default.
- W2094283175 cites W2025125795 @default.
- W2094283175 cites W2025714022 @default.
- W2094283175 cites W2025765615 @default.
- W2094283175 cites W2026263038 @default.
- W2094283175 cites W2026823930 @default.
- W2094283175 cites W2030997817 @default.
- W2094283175 cites W2032879521 @default.
- W2094283175 cites W2034295826 @default.
- W2094283175 cites W2035193789 @default.
- W2094283175 cites W2036036106 @default.
- W2094283175 cites W2036489475 @default.
- W2094283175 cites W2036755018 @default.
- W2094283175 cites W2039402963 @default.
- W2094283175 cites W2041003563 @default.
- W2094283175 cites W2044626031 @default.
- W2094283175 cites W2045089711 @default.
- W2094283175 cites W2046720254 @default.
- W2094283175 cites W2052742260 @default.
- W2094283175 cites W2056510710 @default.
- W2094283175 cites W2057682957 @default.
- W2094283175 cites W2057894590 @default.
- W2094283175 cites W2065327124 @default.
- W2094283175 cites W2069620193 @default.
- W2094283175 cites W2075503787 @default.
- W2094283175 cites W2075580913 @default.
- W2094283175 cites W2076533476 @default.
- W2094283175 cites W2077422298 @default.
- W2094283175 cites W2084079140 @default.
- W2094283175 cites W2084598728 @default.
- W2094283175 cites W2086729582 @default.
- W2094283175 cites W2086747568 @default.
- W2094283175 cites W2092607846 @default.
- W2094283175 cites W2092704615 @default.
- W2094283175 cites W2093822807 @default.
- W2094283175 cites W2093852116 @default.
- W2094283175 cites W2095860147 @default.
- W2094283175 cites W2100026237 @default.
- W2094283175 cites W2100359094 @default.
- W2094283175 cites W2112874709 @default.
- W2094283175 cites W2114358785 @default.
- W2094283175 cites W2115953703 @default.
- W2094283175 cites W2122437043 @default.
- W2094283175 cites W2124019813 @default.
- W2094283175 cites W2125172225 @default.
- W2094283175 cites W2130473558 @default.
- W2094283175 cites W2132315817 @default.
- W2094283175 cites W2133548029 @default.
- W2094283175 cites W2137176838 @default.
- W2094283175 cites W2145440751 @default.
- W2094283175 cites W2149005510 @default.
- W2094283175 cites W2158118162 @default.
- W2094283175 cites W2159377066 @default.
- W2094283175 cites W2162847877 @default.