FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094287260> ?p ?o ?g. }

• W2094287260 endingPage "89" @default.
• W2094287260 startingPage "81" @default.
• W2094287260 abstract "In this study, we have demonstrated the synthesis of a new series of cationic homopolymers based on 3-methacrylamidopropyl)-trimethylammonium chloride (MAPTAC) and block copolymers based on MAPTAC and poly(ethylene glycol) methyl ether acrylate (PEGMA), with the aim of studying their interactions with human serum albumin (HSA). The homopolymer (PMAPTAC) and its block copolymers containing 69 and 84 mol% PEGMA (PMAPTAC-b-PPEGMA69 and PMAPTAC-b-PPEGMA84 respectively) were prepared by RAFT technique. Interactions between human serum albumin (HSA) and these cationic polymers were studied using fluorescence spectroscopy, along with isothermal titration calorimetry (ITC) and circular dichroism (CD). The fluorescence spectra of these protein–polymer complexes revealed considerable binding affinity between PMAPTAC and HSA. However, the block copolymers exhibited relatively lower binding affinities with HSA that decreased with increase in PEGMA block length. CD studies corroborated the fluorescence data by suggesting the formation of protein–polymer complex that led to considerable loss in the negative ellipticity of HSA resulting from partial unfolding of the polypeptide chain. However, in case of the block copolymers, the presence of PEG partly prevented the perturbation of the polypeptide chain induced by polymer–protein interactions. ITC data suggested that the binding was an entropy-driven process. GdmCl denaturation curves showed increased stability of native HSA in presence of PMAPTAC, indicating higher conformational stability of HSA in presence of the cationic homopolymer." @default.
• W2094287260 created "2016-06-24" @default.
• W2094287260 creator A5022524918 @default.
• W2094287260 creator A5029421347 @default.
• W2094287260 creator A5049538348 @default.
• W2094287260 creator A5055686826 @default.
• W2094287260 creator A5082151065 @default.
• W2094287260 date "2014-01-01" @default.
• W2094287260 modified "2023-10-03" @default.
• W2094287260 title "Synthesis of PEG containing cationic block copolymers and their interaction with human serum albumin" @default.
• W2094287260 cites W1500954276 @default.
• W2094287260 cites W1504792186 @default.
• W2094287260 cites W1973238993 @default.
• W2094287260 cites W1973387903 @default.
• W2094287260 cites W1976221898 @default.
• W2094287260 cites W1976436661 @default.
• W2094287260 cites W1977584052 @default.
• W2094287260 cites W1979975654 @default.
• W2094287260 cites W1980106774 @default.
• W2094287260 cites W1990818787 @default.
• W2094287260 cites W1991474019 @default.
• W2094287260 cites W1995725157 @default.
• W2094287260 cites W2001642634 @default.
• W2094287260 cites W2011217599 @default.
• W2094287260 cites W2016227109 @default.
• W2094287260 cites W2018569753 @default.
• W2094287260 cites W2018771924 @default.
• W2094287260 cites W2018951658 @default.
• W2094287260 cites W2024791159 @default.
• W2094287260 cites W2026425764 @default.
• W2094287260 cites W2028729056 @default.
• W2094287260 cites W2036339247 @default.
• W2094287260 cites W2038284856 @default.
• W2094287260 cites W2045020855 @default.
• W2094287260 cites W2045678504 @default.
• W2094287260 cites W2047606685 @default.
• W2094287260 cites W2055393399 @default.
• W2094287260 cites W2056964775 @default.
• W2094287260 cites W2057855619 @default.
• W2094287260 cites W2060085637 @default.
• W2094287260 cites W2062528525 @default.
• W2094287260 cites W2062542146 @default.
• W2094287260 cites W2071055678 @default.
• W2094287260 cites W2075995140 @default.
• W2094287260 cites W2082549153 @default.
• W2094287260 cites W2084327943 @default.
• W2094287260 cites W2085078763 @default.
• W2094287260 cites W2091957363 @default.
• W2094287260 cites W2132827210 @default.
• W2094287260 cites W2137002844 @default.
• W2094287260 cites W2144122182 @default.
• W2094287260 cites W2166644926 @default.
• W2094287260 cites W2171193481 @default.
• W2094287260 cites W4233584722 @default.
• W2094287260 cites W4245614659 @default.
• W2094287260 cites W959649218 @default.
• W2094287260 doi "https://doi.org/10.1016/j.reactfunctpolym.2013.11.001" @default.
• W2094287260 hasPublicationYear "2014" @default.
• W2094287260 type Work @default.
• W2094287260 sameAs 2094287260 @default.
• W2094287260 citedByCount "16" @default.
• W2094287260 countsByYear W20942872602014 @default.
• W2094287260 countsByYear W20942872602015 @default.
• W2094287260 countsByYear W20942872602016 @default.
• W2094287260 countsByYear W20942872602017 @default.
• W2094287260 countsByYear W20942872602021 @default.
• W2094287260 countsByYear W20942872602022 @default.
• W2094287260 crossrefType "journal-article" @default.
• W2094287260 hasAuthorship W2094287260A5022524918 @default.
• W2094287260 hasAuthorship W2094287260A5029421347 @default.
• W2094287260 hasAuthorship W2094287260A5049538348 @default.
• W2094287260 hasAuthorship W2094287260A5055686826 @default.
• W2094287260 hasAuthorship W2094287260A5082151065 @default.
• W2094287260 hasConcept C10138342 @default.
• W2094287260 hasConcept C15920480 @default.
• W2094287260 hasConcept C162324750 @default.
• W2094287260 hasConcept C165616093 @default.
• W2094287260 hasConcept C178790620 @default.
• W2094287260 hasConcept C183882617 @default.
• W2094287260 hasConcept C185592680 @default.
• W2094287260 hasConcept C188027245 @default.
• W2094287260 hasConcept C2776125364 @default.
• W2094287260 hasConcept C2778597219 @default.
• W2094287260 hasConcept C3019038604 @default.
• W2094287260 hasConcept C43617362 @default.
• W2094287260 hasConcept C521977710 @default.
• W2094287260 hasConcept C54400483 @default.
• W2094287260 hasConcept C55493867 @default.
• W2094287260 hasConceptScore W2094287260C10138342 @default.
• W2094287260 hasConceptScore W2094287260C15920480 @default.
• W2094287260 hasConceptScore W2094287260C162324750 @default.
• W2094287260 hasConceptScore W2094287260C165616093 @default.
• W2094287260 hasConceptScore W2094287260C178790620 @default.
• W2094287260 hasConceptScore W2094287260C183882617 @default.
• W2094287260 hasConceptScore W2094287260C185592680 @default.
• W2094287260 hasConceptScore W2094287260C188027245 @default.
• W2094287260 hasConceptScore W2094287260C2776125364 @default.
• W2094287260 hasConceptScore W2094287260C2778597219 @default.

• next