Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094292688> ?p ?o ?g. }
- W2094292688 endingPage "217" @default.
- W2094292688 startingPage "208" @default.
- W2094292688 abstract "Lung carcinogenesis is a complex process involving the acquisition of genetic mutations that confer cancer development and the malignant phenotype, and is critically linked to apoptosis resistance, unregulated proliferation, invasion, metastasis, and angiogenesis. Epithelial mesenchymal transition (EMT) in cancer is an unregulated process in a host environment with deregulated inflammatory response that impairs cell-mediated immunity and permits cancer progression. Given the immunosuppressive tumor environment, strategies to reverse these events by stimulating host immune responses are an important area of investigation. Cyclooxygenase 2 (COX-2) and its downstream signaling pathways are potential targets for lung cancer chemoprevention and therapy. Clinical trials are underway to evaluate COX-2 inhibitors as adjuvants to chemotherapy in patients with lung cancer and to determine efficacy in prevention of bronchogenic carcinoma. The understanding of molecular mechanisms involved in inflammation and lung carcinogenesis provide insight for new drug development that target reversible, non-mutational events in the chemoprevention and treatment of lung cancer." @default.
- W2094292688 created "2016-06-24" @default.
- W2094292688 creator A5000739628 @default.
- W2094292688 creator A5002656601 @default.
- W2094292688 creator A5013898461 @default.
- W2094292688 creator A5030752382 @default.
- W2094292688 creator A5059818425 @default.
- W2094292688 creator A5073274148 @default.
- W2094292688 date "2008-06-01" @default.
- W2094292688 modified "2023-10-01" @default.
- W2094292688 title "Inflammation in lung carcinogenesis: New targets for lung cancer chemoprevention and treatment" @default.
- W2094292688 cites W1482218984 @default.
- W2094292688 cites W1515113188 @default.
- W2094292688 cites W1530782041 @default.
- W2094292688 cites W1611284225 @default.
- W2094292688 cites W1640854798 @default.
- W2094292688 cites W192003713 @default.
- W2094292688 cites W1957316132 @default.
- W2094292688 cites W1963272169 @default.
- W2094292688 cites W1963333787 @default.
- W2094292688 cites W1965734230 @default.
- W2094292688 cites W1966473790 @default.
- W2094292688 cites W1967257081 @default.
- W2094292688 cites W1973537311 @default.
- W2094292688 cites W1976999017 @default.
- W2094292688 cites W1985231066 @default.
- W2094292688 cites W1987473368 @default.
- W2094292688 cites W1993345123 @default.
- W2094292688 cites W1995528018 @default.
- W2094292688 cites W2001476006 @default.
- W2094292688 cites W2002955275 @default.
- W2094292688 cites W2007187686 @default.
- W2094292688 cites W2010831019 @default.
- W2094292688 cites W2010967782 @default.
- W2094292688 cites W2012592378 @default.
- W2094292688 cites W2017249285 @default.
- W2094292688 cites W2018029930 @default.
- W2094292688 cites W2019737644 @default.
- W2094292688 cites W2023389550 @default.
- W2094292688 cites W2023389612 @default.
- W2094292688 cites W2024289681 @default.
- W2094292688 cites W2024579029 @default.
- W2094292688 cites W2027274360 @default.
- W2094292688 cites W2038084627 @default.
- W2094292688 cites W2039298921 @default.
- W2094292688 cites W2043707891 @default.
- W2094292688 cites W2050310941 @default.
- W2094292688 cites W2050717908 @default.
- W2094292688 cites W2053945436 @default.
- W2094292688 cites W2054456797 @default.
- W2094292688 cites W2057251984 @default.
- W2094292688 cites W2062121229 @default.
- W2094292688 cites W2062142808 @default.
- W2094292688 cites W2067971586 @default.
- W2094292688 cites W2068806248 @default.
- W2094292688 cites W2073042812 @default.
- W2094292688 cites W2073738021 @default.
- W2094292688 cites W2074045134 @default.
- W2094292688 cites W2077462602 @default.
- W2094292688 cites W2077985675 @default.
- W2094292688 cites W2078422697 @default.
- W2094292688 cites W2079763362 @default.
- W2094292688 cites W2081951714 @default.
- W2094292688 cites W2083519527 @default.
- W2094292688 cites W2088179332 @default.
- W2094292688 cites W2090928408 @default.
- W2094292688 cites W2093654484 @default.
- W2094292688 cites W2094206460 @default.
- W2094292688 cites W2100201127 @default.
- W2094292688 cites W2101230909 @default.
- W2094292688 cites W2104387817 @default.
- W2094292688 cites W2105505234 @default.
- W2094292688 cites W2106052085 @default.
- W2094292688 cites W2106293055 @default.
- W2094292688 cites W2107402652 @default.
- W2094292688 cites W2111439621 @default.
- W2094292688 cites W2114866206 @default.
- W2094292688 cites W2115485344 @default.
- W2094292688 cites W2116508360 @default.
- W2094292688 cites W2124289149 @default.
- W2094292688 cites W2124781291 @default.
- W2094292688 cites W2125311191 @default.
- W2094292688 cites W2125594974 @default.
- W2094292688 cites W2126853519 @default.
- W2094292688 cites W2127773617 @default.
- W2094292688 cites W2127987617 @default.
- W2094292688 cites W2128905862 @default.
- W2094292688 cites W2129047107 @default.
- W2094292688 cites W2131578906 @default.
- W2094292688 cites W2135393211 @default.
- W2094292688 cites W2142899523 @default.
- W2094292688 cites W2144156694 @default.
- W2094292688 cites W2144320908 @default.
- W2094292688 cites W2146708145 @default.
- W2094292688 cites W2149233326 @default.
- W2094292688 cites W2156670712 @default.
- W2094292688 cites W2159725359 @default.
- W2094292688 cites W2159987448 @default.