FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094296799> ?p ?o ?g. }

• W2094296799 endingPage "258" @default.
• W2094296799 startingPage "244" @default.
• W2094296799 abstract "Actin pedestal formation by pathogenic E. coli requires signaling by the bacterial intimin receptor Tir, which induces host cell actin polymerization mediated by N-WASP and the Arp2/3 complex. Whereas canonical enteropathogenic E. coli (EPEC) recruit these actin regulators through tyrosine kinase signaling cascades, enterohemorrhagic E. coli (EHEC) O157:H7 employ the bacterial effector EspFU (TccP), a potent N-WASP activator. Here, we show that IRSp53 family members, key regulators of membrane and actin dynamics, directly interact with both Tir and EspFU. IRSp53 colocalizes with EspFU and N-WASP in actin pedestals. In addition, targeting of IRSp53 is independent of EspFU and N-WASP but requires Tir residues 454–463, previously shown to be essential for EspFU-dependent actin assembly. Genetic and functional loss of IRSp53 abrogates actin assembly mediated by EHEC. Collectively, these data indentify IRSp53 family proteins as the missing host cell factors linking bacterial Tir and EspFU in EHEC pedestal formation." @default.
• W2094296799 created "2016-06-24" @default.
• W2094296799 creator A5013634269 @default.
• W2094296799 creator A5015140374 @default.
• W2094296799 creator A5036132330 @default.
• W2094296799 creator A5037125160 @default.
• W2094296799 creator A5046499448 @default.
• W2094296799 creator A5056763437 @default.
• W2094296799 creator A5063042451 @default.
• W2094296799 creator A5065085141 @default.
• W2094296799 creator A5066456827 @default.
• W2094296799 creator A5068174660 @default.
• W2094296799 creator A5078950634 @default.
• W2094296799 creator A5084314638 @default.
• W2094296799 creator A5085532354 @default.
• W2094296799 creator A5088547780 @default.
• W2094296799 date "2009-03-01" @default.
• W2094296799 modified "2023-10-01" @default.
• W2094296799 title "IRSp53 Links the Enterohemorrhagic E. coli Effectors Tir and EspFU for Actin Pedestal Formation" @default.
• W2094296799 cites W1551012459 @default.
• W2094296799 cites W1571919210 @default.
• W2094296799 cites W1966081550 @default.
• W2094296799 cites W1968415876 @default.
• W2094296799 cites W1970046422 @default.
• W2094296799 cites W1970347595 @default.
• W2094296799 cites W1973247376 @default.
• W2094296799 cites W1978492395 @default.
• W2094296799 cites W1979143773 @default.
• W2094296799 cites W1981129391 @default.
• W2094296799 cites W1981593008 @default.
• W2094296799 cites W1982863538 @default.
• W2094296799 cites W1985830493 @default.
• W2094296799 cites W1988067222 @default.
• W2094296799 cites W1988771590 @default.
• W2094296799 cites W1994936546 @default.
• W2094296799 cites W1999820067 @default.
• W2094296799 cites W2005047484 @default.
• W2094296799 cites W2008916405 @default.
• W2094296799 cites W2009420240 @default.
• W2094296799 cites W2014913899 @default.
• W2094296799 cites W2020422209 @default.
• W2094296799 cites W2022548531 @default.
• W2094296799 cites W2025728213 @default.
• W2094296799 cites W2029022457 @default.
• W2094296799 cites W2044084413 @default.
• W2094296799 cites W2048428229 @default.
• W2094296799 cites W2053527054 @default.
• W2094296799 cites W2053994471 @default.
• W2094296799 cites W2057132767 @default.
• W2094296799 cites W2059477980 @default.
• W2094296799 cites W2063744622 @default.
• W2094296799 cites W2064258387 @default.
• W2094296799 cites W2072422743 @default.
• W2094296799 cites W2074215706 @default.
• W2094296799 cites W2080421926 @default.
• W2094296799 cites W2081076131 @default.
• W2094296799 cites W2087298251 @default.
• W2094296799 cites W2088812171 @default.
• W2094296799 cites W2092040620 @default.
• W2094296799 cites W2099544870 @default.
• W2094296799 cites W2101736420 @default.
• W2094296799 cites W2107625881 @default.
• W2094296799 cites W2131159435 @default.
• W2094296799 cites W2133258573 @default.
• W2094296799 cites W2135606345 @default.
• W2094296799 cites W2136163749 @default.
• W2094296799 cites W2139784023 @default.
• W2094296799 cites W2141365498 @default.
• W2094296799 cites W2152869773 @default.
• W2094296799 cites W2154824060 @default.
• W2094296799 cites W2155121556 @default.
• W2094296799 cites W2170996392 @default.
• W2094296799 doi "https://doi.org/10.1016/j.chom.2009.02.003" @default.
• W2094296799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19286134" @default.
• W2094296799 hasPublicationYear "2009" @default.
• W2094296799 type Work @default.
• W2094296799 sameAs 2094296799 @default.
• W2094296799 citedByCount "95" @default.
• W2094296799 countsByYear W20942967992012 @default.
• W2094296799 countsByYear W20942967992013 @default.
• W2094296799 countsByYear W20942967992014 @default.
• W2094296799 countsByYear W20942967992015 @default.
• W2094296799 countsByYear W20942967992016 @default.
• W2094296799 countsByYear W20942967992017 @default.
• W2094296799 countsByYear W20942967992018 @default.
• W2094296799 countsByYear W20942967992019 @default.
• W2094296799 countsByYear W20942967992020 @default.
• W2094296799 countsByYear W20942967992021 @default.
• W2094296799 countsByYear W20942967992022 @default.
• W2094296799 countsByYear W20942967992023 @default.
• W2094296799 crossrefType "journal-article" @default.
• W2094296799 hasAuthorship W2094296799A5013634269 @default.
• W2094296799 hasAuthorship W2094296799A5015140374 @default.
• W2094296799 hasAuthorship W2094296799A5036132330 @default.
• W2094296799 hasAuthorship W2094296799A5037125160 @default.
• W2094296799 hasAuthorship W2094296799A5046499448 @default.
• W2094296799 hasAuthorship W2094296799A5056763437 @default.
• W2094296799 hasAuthorship W2094296799A5063042451 @default.

• next