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• W2094302275 endingPage "e1004419" @default.
• W2094302275 startingPage "e1004419" @default.
• W2094302275 abstract "Translesion synthesis (TLS) enables DNA replication through damaged bases, increases cellular DNA damage tolerance, and maintains genomic stability. The sliding clamp PCNA and the adaptor polymerase Rev1 coordinate polymerase switching during TLS. The polymerases Pol η, ι, and κ insert nucleotides opposite damaged bases. Pol ζ, consisting of the catalytic subunit Rev3 and the regulatory subunit Rev7, then extends DNA synthesis past the lesion. Here, we show that Rev7 binds to the transcription factor TFII-I in human cells. TFII-I is required for TLS and DNA damage tolerance. The TLS function of TFII-I appears to be independent of its role in transcription, but requires homodimerization and binding to PCNA. We propose that TFII-I bridges PCNA and Pol ζ to promote TLS. Our findings extend the general principle of component sharing among divergent nuclear processes and implicate TLS deficiency as a possible contributing factor in Williams-Beuren syndrome." @default.
• W2094302275 created "2016-06-24" @default.
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• W2094302275 date "2014-06-12" @default.
• W2094302275 modified "2023-10-18" @default.
• W2094302275 title "The Transcription Factor TFII-I Promotes DNA Translesion Synthesis and Genomic Stability" @default.
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• W2094302275 doi "https://doi.org/10.1371/journal.pgen.1004419" @default.
• W2094302275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4055408" @default.
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• W2094302275 hasPublicationYear "2014" @default.
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