FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094313458> ?p ?o ?g. }

• W2094313458 endingPage "39" @default.
• W2094313458 startingPage "29" @default.
• W2094313458 abstract "An active pharmaceutical ingredient (API) was found to dissociate from the highly crystalline hydrochloride form to the amorphous free base form, with consequent alterations to tablet properties. Here, a wet granulation manufacturing process has been investigated using in situ Fourier transform (FT)-Raman spectroscopic analyses of granules and tablets prepared with different granulating fluids and under different manufacturing conditions. Dosage form stability under a range of storage stresses was also investigated. Despite the spectral similarities between the two drug forms, low levels of API dissociation could be quantified in the tablets; the technique allowed discrimination of around 4% of the API content as the amorphous free base (i.e. less than 1% of the tablet compression weight). API dissociation was shown to be promoted by extended exposure to moisture. Aqueous granulating fluids and manufacturing delays between granulation and drying stages and storage of the tablets in open conditions at 40 °C/75% relative humidity (RH) led to dissociation. In contrast, non-aqueous granulating fluids, with no delay in processing and storage of the tablets in either sealed containers or at lower temperature/humidity prevented detectable dissociation. It is concluded that appropriate manufacturing process and storage conditions for the finished product involved minimising exposure to moisture of the API. Analysis of the drug using FT-Raman spectroscopy allowed rapid optimisation of the process whilst offering quantitative molecular information concerning the dissociation of the drug salt to the amorphous free base form." @default.
• W2094313458 created "2016-06-24" @default.
• W2094313458 creator A5010310569 @default.
• W2094313458 creator A5014166303 @default.
• W2094313458 creator A5022568201 @default.
• W2094313458 creator A5031510424 @default.
• W2094313458 creator A5042453958 @default.
• W2094313458 creator A5077826287 @default.
• W2094313458 date "2004-05-01" @default.
• W2094313458 modified "2023-10-14" @default.
• W2094313458 title "Evaluation of drug physical form during granulation, tabletting and storage" @default.
• W2094313458 cites W130874531 @default.
• W2094313458 cites W1557336693 @default.
• W2094313458 cites W1988980384 @default.
• W2094313458 cites W1997373404 @default.
• W2094313458 cites W2003731034 @default.
• W2094313458 cites W2014911655 @default.
• W2094313458 cites W2024630219 @default.
• W2094313458 cites W2050273054 @default.
• W2094313458 cites W2052081265 @default.
• W2094313458 cites W2073372113 @default.
• W2094313458 cites W2078924544 @default.
• W2094313458 cites W3022113467 @default.
• W2094313458 cites W4248644392 @default.
• W2094313458 doi "https://doi.org/10.1016/j.ijpharm.2004.01.042" @default.
• W2094313458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15081136" @default.
• W2094313458 hasPublicationYear "2004" @default.
• W2094313458 type Work @default.
• W2094313458 sameAs 2094313458 @default.
• W2094313458 citedByCount "66" @default.
• W2094313458 countsByYear W20943134582012 @default.
• W2094313458 countsByYear W20943134582013 @default.
• W2094313458 countsByYear W20943134582014 @default.
• W2094313458 countsByYear W20943134582015 @default.
• W2094313458 countsByYear W20943134582016 @default.
• W2094313458 countsByYear W20943134582017 @default.
• W2094313458 countsByYear W20943134582018 @default.
• W2094313458 countsByYear W20943134582019 @default.
• W2094313458 countsByYear W20943134582020 @default.
• W2094313458 countsByYear W20943134582022 @default.
• W2094313458 countsByYear W20943134582023 @default.
• W2094313458 crossrefType "journal-article" @default.
• W2094313458 hasAuthorship W2094313458A5010310569 @default.
• W2094313458 hasAuthorship W2094313458A5014166303 @default.
• W2094313458 hasAuthorship W2094313458A5022568201 @default.
• W2094313458 hasAuthorship W2094313458A5031510424 @default.
• W2094313458 hasAuthorship W2094313458A5042453958 @default.
• W2094313458 hasAuthorship W2094313458A5077826287 @default.
• W2094313458 hasConcept C102931765 @default.
• W2094313458 hasConcept C120665830 @default.
• W2094313458 hasConcept C121332964 @default.
• W2094313458 hasConcept C127413603 @default.
• W2094313458 hasConcept C158960510 @default.
• W2094313458 hasConcept C159985019 @default.
• W2094313458 hasConcept C178144697 @default.
• W2094313458 hasConcept C178790620 @default.
• W2094313458 hasConcept C184651966 @default.
• W2094313458 hasConcept C185592680 @default.
• W2094313458 hasConcept C192562407 @default.
• W2094313458 hasConcept C40003534 @default.
• W2094313458 hasConcept C42360764 @default.
• W2094313458 hasConcept C43617362 @default.
• W2094313458 hasConcept C45904493 @default.
• W2094313458 hasConcept C4916135 @default.
• W2094313458 hasConcept C56052488 @default.
• W2094313458 hasConcept C60644358 @default.
• W2094313458 hasConcept C77281830 @default.
• W2094313458 hasConcept C86803240 @default.
• W2094313458 hasConcept C88463166 @default.
• W2094313458 hasConcept C97355855 @default.
• W2094313458 hasConceptScore W2094313458C102931765 @default.
• W2094313458 hasConceptScore W2094313458C120665830 @default.
• W2094313458 hasConceptScore W2094313458C121332964 @default.
• W2094313458 hasConceptScore W2094313458C127413603 @default.
• W2094313458 hasConceptScore W2094313458C158960510 @default.
• W2094313458 hasConceptScore W2094313458C159985019 @default.
• W2094313458 hasConceptScore W2094313458C178144697 @default.
• W2094313458 hasConceptScore W2094313458C178790620 @default.
• W2094313458 hasConceptScore W2094313458C184651966 @default.
• W2094313458 hasConceptScore W2094313458C185592680 @default.
• W2094313458 hasConceptScore W2094313458C192562407 @default.
• W2094313458 hasConceptScore W2094313458C40003534 @default.
• W2094313458 hasConceptScore W2094313458C42360764 @default.
• W2094313458 hasConceptScore W2094313458C43617362 @default.
• W2094313458 hasConceptScore W2094313458C45904493 @default.
• W2094313458 hasConceptScore W2094313458C4916135 @default.
• W2094313458 hasConceptScore W2094313458C56052488 @default.
• W2094313458 hasConceptScore W2094313458C60644358 @default.
• W2094313458 hasConceptScore W2094313458C77281830 @default.
• W2094313458 hasConceptScore W2094313458C86803240 @default.
• W2094313458 hasConceptScore W2094313458C88463166 @default.
• W2094313458 hasConceptScore W2094313458C97355855 @default.
• W2094313458 hasIssue "1-2" @default.
• W2094313458 hasLocation W20943134581 @default.
• W2094313458 hasLocation W20943134582 @default.
• W2094313458 hasOpenAccess W2094313458 @default.
• W2094313458 hasPrimaryLocation W20943134581 @default.
• W2094313458 hasRelatedWork W1984899361 @default.

• next