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• W2094314450 endingPage "613" @default.
• W2094314450 startingPage "593" @default.
• W2094314450 abstract "A major reason for clinical variations between opioids is differences in their physicochemical and pharmacokinetic properties. Important factors are pKa, lipid solubility and protein binding. Opioids are basic drugs that, with the exception of alfentanil, have pKa values greater than 7.4, so that the ionized form of the drug predominates in the blood. The pKa of alfentanil is 6.5 so that 90% of alfentanil is non-ionized at pH 7.4. This facilitates its access into the CNS. pKa is also an important determinant of absorption from the gastrointestinal tract. Opioid pharmacokinetics are also affected by changes in blood and tissue pH (e.g. during respiratory alkalosis). While morphine is mainly bound to albumin, the most important binding protein for the fentanyl analogues is α1-acid glycoprotein (AAG). Change in the concentration of this protein can affect opioid pharmacodynamics, and has special relevance during pregnancy and in the newborn. Because of immaturity of the cytochrome P-450 isoenzyme system, neonates metabolize opioids much less efficiently than older children or adults. Generally the pharmacokinetics of an opioid are similar in children and in young adults, although often clearance is greater in young children. In elderly patients the influence of age on opioid pharmacokinetics is less well defined and many of the clinical differences between young and elderly patients in their responses to opioids may be due to pharmacodynamic differences or attributable to concomitant diseases or medication. The pharmacokinetics of these drugs are also influenced by renal and hepatic disease, although the extent is very drug dependent. The elimination of morphine metabolites is especially affected by decreases in renal filtration. Not surprisingly, cardiac surgery with cardiopulmonary bypass markedly affects opioid pharmacokinetics. Apart from changes in distribution volume and hepatic clearance, sequestration of opioids on to the extracorporeal circuit may be important for some opioids. Significant uptake of opioids by the lungs has also been demonstrated." @default.
• W2094314450 created "2016-06-24" @default.
• W2094314450 creator A5033710492 @default.
• W2094314450 date "1991-12-01" @default.
• W2094314450 modified "2023-09-27" @default.
• W2094314450 title "Pharmacokinetics of opioid agonists and antagonists" @default.
• W2094314450 cites W1859104473 @default.
• W2094314450 cites W1964609099 @default.
• W2094314450 cites W1965799818 @default.
• W2094314450 cites W1968393056 @default.
• W2094314450 cites W1970648957 @default.
• W2094314450 cites W1972783861 @default.
• W2094314450 cites W1973043914 @default.
• W2094314450 cites W1974426685 @default.
• W2094314450 cites W1975183736 @default.
• W2094314450 cites W1979359878 @default.
• W2094314450 cites W1983672873 @default.
• W2094314450 cites W1984624729 @default.
• W2094314450 cites W1986565384 @default.
• W2094314450 cites W1986703676 @default.
• W2094314450 cites W1996565727 @default.
• W2094314450 cites W1997016310 @default.
• W2094314450 cites W1999196026 @default.
• W2094314450 cites W2002718858 @default.
• W2094314450 cites W2003005452 @default.
• W2094314450 cites W2006786717 @default.
• W2094314450 cites W2007663368 @default.
• W2094314450 cites W2008910823 @default.
• W2094314450 cites W2012513302 @default.
• W2094314450 cites W2012944396 @default.
• W2094314450 cites W2014219816 @default.
• W2094314450 cites W2014384466 @default.
• W2094314450 cites W2015208768 @default.
• W2094314450 cites W2015569636 @default.
• W2094314450 cites W2016169214 @default.
• W2094314450 cites W2018985419 @default.
• W2094314450 cites W2021373864 @default.
• W2094314450 cites W2023187279 @default.
• W2094314450 cites W2023741138 @default.
• W2094314450 cites W2026057791 @default.
• W2094314450 cites W2027210220 @default.
• W2094314450 cites W2030094679 @default.
• W2094314450 cites W2032671856 @default.
• W2094314450 cites W2034091997 @default.
• W2094314450 cites W2038635568 @default.
• W2094314450 cites W2041539882 @default.
• W2094314450 cites W2041830654 @default.
• W2094314450 cites W2044455629 @default.
• W2094314450 cites W2047326145 @default.
• W2094314450 cites W2047925069 @default.
• W2094314450 cites W2048885921 @default.
• W2094314450 cites W2049937760 @default.
• W2094314450 cites W2051545569 @default.
• W2094314450 cites W2054514234 @default.
• W2094314450 cites W2055387298 @default.
• W2094314450 cites W2056627166 @default.
• W2094314450 cites W2057132908 @default.
• W2094314450 cites W2058816390 @default.
• W2094314450 cites W2059767435 @default.
• W2094314450 cites W2059941531 @default.
• W2094314450 cites W2060435731 @default.
• W2094314450 cites W2061297691 @default.
• W2094314450 cites W2062860470 @default.
• W2094314450 cites W2066297221 @default.
• W2094314450 cites W2074357115 @default.
• W2094314450 cites W2075155877 @default.
• W2094314450 cites W2079309430 @default.
• W2094314450 cites W2082402996 @default.
• W2094314450 cites W2082874172 @default.
• W2094314450 cites W2082949601 @default.
• W2094314450 cites W2083903015 @default.
• W2094314450 cites W2084667341 @default.
• W2094314450 cites W2085093423 @default.
• W2094314450 cites W2085180010 @default.
• W2094314450 cites W2086748896 @default.
• W2094314450 cites W2087536686 @default.
• W2094314450 cites W2088488508 @default.
• W2094314450 cites W2092792187 @default.
• W2094314450 cites W2093412557 @default.
• W2094314450 cites W2095086150 @default.
• W2094314450 cites W2095533909 @default.
• W2094314450 cites W2107613102 @default.
• W2094314450 cites W2108546256 @default.
• W2094314450 cites W2110036437 @default.
• W2094314450 cites W2110115380 @default.
• W2094314450 cites W2110270487 @default.
• W2094314450 cites W2118093016 @default.
• W2094314450 cites W2128475256 @default.
• W2094314450 cites W2132711159 @default.
• W2094314450 cites W2135467624 @default.
• W2094314450 cites W2147577471 @default.
• W2094314450 cites W2256687902 @default.
• W2094314450 cites W4235129265 @default.
• W2094314450 cites W4243730411 @default.
• W2094314450 cites W4245793903 @default.
• W2094314450 cites W4249992022 @default.
• W2094314450 cites W4251693155 @default.
• W2094314450 cites W4301808520 @default.

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