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- W2094316615 abstract "Fibrinogen has been included among the risk factors for vascular disease. Fibrinogen belongs with albumin, ceruloplasmin and transferrin to an acute phase protein group in the plasma. Albumin, ceruloplasmin and transferrin are already recognized as natural antioxidants. In the present study we used three different oxygen generating systems in order to test whether fibrinogen is able to act as an antioxidant in an in vitro system. We used 1) pyrogallol auto-oxidation, 2) the reaction catalysed by xanthine oxidase coupled with the reduction of ferricytochrome c and 3) chemiluminescence. We found that in a dose-dependent manner fibrinogen inhibited superoxide generation (pyrogallol and xanthine-xanthine oxidase reactions), ferrous ion oxidation and hydroxyl radical dependent degradation (of deoxyribose). Fibrinogen also inhibited LDL oxidation (copper and azo compound-induced), hydrogen peroxide oxidation and chemiluminescence produced by polymorphonuclear leukocytes. Fibrinogen, albumin, ceruloplasmin and transferrin act as a supplementary antioxidant defense mechanism against oxidative stress arising from inflammatory conditions." @default.
- W2094316615 created "2016-06-24" @default.
- W2094316615 creator A5005425815 @default.
- W2094316615 creator A5070597794 @default.
- W2094316615 date "2001-03-01" @default.
- W2094316615 modified "2023-10-17" @default.
- W2094316615 title "Fibrinogen is an efficient antioxidant" @default.
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- W2094316615 doi "https://doi.org/10.1016/s0955-2863(00)00147-9" @default.
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