Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094321481> ?p ?o ?g. }
- W2094321481 endingPage "490" @default.
- W2094321481 startingPage "485" @default.
- W2094321481 abstract "The neuroprotective potential of mGluR1 and mGluR5 antagonists (group I), EMQMCM and MTEP, respectively was studied using the 3 min forebrain ischemia model in Mongolian gerbils and the hypoxia–ischemia model in 7-day-old rats. Hypoxia–ischemia was induced by unilateral carotid occlusion followed by 75 min exposure to hypoxia (7.3% O2 in N2), forebrain ischemia in gerbils was evoked by bilateral common carotid artery occlusion. The postischemic rectal body temperature in rat pups or brain temperature of gerbils was measured. The drugs were administered i.p. three times every 2 h after the insult, each time in equal doses of 1.25, 2.5 or 5.0 mg/kg. After 2 weeks brain damage was evaluated as weight decrease of the ipsilateral hemisphere in the rat pups or damage to CA1 pyramids in the gerbil hippocampus. The results demonstrated a dose dependent neuroprotection in both ischemic models by EMQMCM, while MTEP was neuroprotective only in the gerbil model of forebrain ischemia. EMQMCM reduced postischemic hyperthermia in gerbils. Thus, the antagonists of mGluR1 and mGluR5 show differential neuroprotective ability in two models of brain ischemia. Postischemic hypothermia may be partially involved in the mechanism of neuroprotection following EMQMCM in gerbils." @default.
- W2094321481 created "2016-06-24" @default.
- W2094321481 creator A5059942898 @default.
- W2094321481 creator A5060706996 @default.
- W2094321481 creator A5062271410 @default.
- W2094321481 creator A5075369944 @default.
- W2094321481 creator A5089913799 @default.
- W2094321481 date "2006-05-01" @default.
- W2094321481 modified "2023-10-16" @default.
- W2094321481 title "Neuroprotective potential of group I metabotropic glutamate receptor antagonists in two ischemic models" @default.
- W2094321481 cites W1541190820 @default.
- W2094321481 cites W1970427487 @default.
- W2094321481 cites W1970863115 @default.
- W2094321481 cites W1972131017 @default.
- W2094321481 cites W1977528259 @default.
- W2094321481 cites W1991597843 @default.
- W2094321481 cites W2002674888 @default.
- W2094321481 cites W2007411105 @default.
- W2094321481 cites W2010472439 @default.
- W2094321481 cites W2014874061 @default.
- W2094321481 cites W2017505808 @default.
- W2094321481 cites W2018229563 @default.
- W2094321481 cites W2023997512 @default.
- W2094321481 cites W2027792516 @default.
- W2094321481 cites W2031315226 @default.
- W2094321481 cites W2031898343 @default.
- W2094321481 cites W2034524677 @default.
- W2094321481 cites W2036755665 @default.
- W2094321481 cites W2044598463 @default.
- W2094321481 cites W2049830081 @default.
- W2094321481 cites W2060714812 @default.
- W2094321481 cites W2061268684 @default.
- W2094321481 cites W2067215294 @default.
- W2094321481 cites W2073732519 @default.
- W2094321481 cites W2080656191 @default.
- W2094321481 cites W2098150710 @default.
- W2094321481 cites W2126174089 @default.
- W2094321481 cites W2136967026 @default.
- W2094321481 cites W2144303480 @default.
- W2094321481 cites W2146638685 @default.
- W2094321481 cites W2149180221 @default.
- W2094321481 cites W2153262391 @default.
- W2094321481 cites W2319201633 @default.
- W2094321481 doi "https://doi.org/10.1016/j.neuint.2005.12.022" @default.
- W2094321481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16513218" @default.
- W2094321481 hasPublicationYear "2006" @default.
- W2094321481 type Work @default.
- W2094321481 sameAs 2094321481 @default.
- W2094321481 citedByCount "31" @default.
- W2094321481 countsByYear W20943214812012 @default.
- W2094321481 countsByYear W20943214812013 @default.
- W2094321481 countsByYear W20943214812014 @default.
- W2094321481 countsByYear W20943214812015 @default.
- W2094321481 countsByYear W20943214812017 @default.
- W2094321481 countsByYear W20943214812020 @default.
- W2094321481 countsByYear W20943214812021 @default.
- W2094321481 countsByYear W20943214812022 @default.
- W2094321481 countsByYear W20943214812023 @default.
- W2094321481 crossrefType "journal-article" @default.
- W2094321481 hasAuthorship W2094321481A5059942898 @default.
- W2094321481 hasAuthorship W2094321481A5060706996 @default.
- W2094321481 hasAuthorship W2094321481A5062271410 @default.
- W2094321481 hasAuthorship W2094321481A5075369944 @default.
- W2094321481 hasAuthorship W2094321481A5089913799 @default.
- W2094321481 hasConcept C126322002 @default.
- W2094321481 hasConcept C134018914 @default.
- W2094321481 hasConcept C170493617 @default.
- W2094321481 hasConcept C25498285 @default.
- W2094321481 hasConcept C2780222073 @default.
- W2094321481 hasConcept C2781161787 @default.
- W2094321481 hasConcept C42219234 @default.
- W2094321481 hasConcept C49051014 @default.
- W2094321481 hasConcept C541997718 @default.
- W2094321481 hasConcept C61174792 @default.
- W2094321481 hasConcept C71924100 @default.
- W2094321481 hasConcept C98274493 @default.
- W2094321481 hasConceptScore W2094321481C126322002 @default.
- W2094321481 hasConceptScore W2094321481C134018914 @default.
- W2094321481 hasConceptScore W2094321481C170493617 @default.
- W2094321481 hasConceptScore W2094321481C25498285 @default.
- W2094321481 hasConceptScore W2094321481C2780222073 @default.
- W2094321481 hasConceptScore W2094321481C2781161787 @default.
- W2094321481 hasConceptScore W2094321481C42219234 @default.
- W2094321481 hasConceptScore W2094321481C49051014 @default.
- W2094321481 hasConceptScore W2094321481C541997718 @default.
- W2094321481 hasConceptScore W2094321481C61174792 @default.
- W2094321481 hasConceptScore W2094321481C71924100 @default.
- W2094321481 hasConceptScore W2094321481C98274493 @default.
- W2094321481 hasIssue "6-7" @default.
- W2094321481 hasLocation W20943214811 @default.
- W2094321481 hasLocation W20943214812 @default.
- W2094321481 hasOpenAccess W2094321481 @default.
- W2094321481 hasPrimaryLocation W20943214811 @default.
- W2094321481 hasRelatedWork W1967466101 @default.
- W2094321481 hasRelatedWork W1987346984 @default.
- W2094321481 hasRelatedWork W2003781670 @default.
- W2094321481 hasRelatedWork W2020119741 @default.
- W2094321481 hasRelatedWork W2031525113 @default.