Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094329342> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2094329342 endingPage "721" @default.
- W2094329342 startingPage "716" @default.
- W2094329342 abstract "Left ventricular contractility and the energetic cost of contraction were assessed in various disease models in experimental animals utilizing frameworks of Emax (left ventricular contractility index) and pressure-volume area (PVA, a measure of total left ventricular mechanical energy expenditure) derived from the pressure-volume (P-V) diagram. Under various contractile conditions, PVA linearly correlates with myocardial oxygen consumption per beat (VO2) in a load-independent manner. The reciprocal of the slope of the linear VO2-PVA relation indicates contractile efficiency (the energy transduction efficiency from oxygen to total mechanical energy). It was similar between dog and rabbit hearts (about 40%) and was not significantly affected by enhanced contractility with calcium, epinephrine, or cardiac cooling, or by depressed contractility with propranolol, decreased coronary perfusion pressure, or stunned myocardium. However, in thyrotoxic rabbit hearts contractile efficiency was significantly depressed compared to normal hearts. On the other hand, the VO2 intercept of the VO2-PVA relation (PVA-independent VO2), which reflects VO2 for non-mechanical activities such as excitation-contraction coupling and basal metabolism, positively correlates with Emax' Therefore, the ratio of an increase in PVA-independent VO2 to an increase in Emax indicates oxygen cost of contractility. Oxygen cost of contractility was higher in stunned myocardium than in normal hearts, suggesting that the energy cost of calcium handling is elevated in stunned myocardium. Thus, using the frameworks of Emax and PVA, we can interconnect cardiac mechanics and energetics. Further, using the concepts of contractile efficiency and oxygen cost of contractility, we can approach the pathogenesis of variously altered contractile conditions." @default.
- W2094329342 created "2016-06-24" @default.
- W2094329342 creator A5038063671 @default.
- W2094329342 creator A5044676548 @default.
- W2094329342 creator A5048246357 @default.
- W2094329342 creator A5054598335 @default.
- W2094329342 creator A5060203512 @default.
- W2094329342 creator A5065308273 @default.
- W2094329342 creator A5081419924 @default.
- W2094329342 creator A5085089306 @default.
- W2094329342 date "1992-01-01" @default.
- W2094329342 modified "2023-09-25" @default.
- W2094329342 title "Left Ventricular Contractility and Energetic Cost in Disease Models. An approach from the pressure-volume diagram." @default.
- W2094329342 doi "https://doi.org/10.1253/jcj.56.716" @default.
- W2094329342 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1495163" @default.
- W2094329342 hasPublicationYear "1992" @default.
- W2094329342 type Work @default.
- W2094329342 sameAs 2094329342 @default.
- W2094329342 citedByCount "6" @default.
- W2094329342 countsByYear W20943293422014 @default.
- W2094329342 countsByYear W20943293422018 @default.
- W2094329342 countsByYear W20943293422020 @default.
- W2094329342 crossrefType "journal-article" @default.
- W2094329342 hasAuthorship W2094329342A5038063671 @default.
- W2094329342 hasAuthorship W2094329342A5044676548 @default.
- W2094329342 hasAuthorship W2094329342A5048246357 @default.
- W2094329342 hasAuthorship W2094329342A5054598335 @default.
- W2094329342 hasAuthorship W2094329342A5060203512 @default.
- W2094329342 hasAuthorship W2094329342A5065308273 @default.
- W2094329342 hasAuthorship W2094329342A5081419924 @default.
- W2094329342 hasAuthorship W2094329342A5085089306 @default.
- W2094329342 hasBestOaLocation W20943293421 @default.
- W2094329342 hasConcept C126322002 @default.
- W2094329342 hasConcept C163415756 @default.
- W2094329342 hasConcept C164705383 @default.
- W2094329342 hasConcept C178790620 @default.
- W2094329342 hasConcept C185592680 @default.
- W2094329342 hasConcept C26635844 @default.
- W2094329342 hasConcept C39078644 @default.
- W2094329342 hasConcept C39133596 @default.
- W2094329342 hasConcept C540031477 @default.
- W2094329342 hasConcept C57900726 @default.
- W2094329342 hasConcept C71924100 @default.
- W2094329342 hasConcept C84393581 @default.
- W2094329342 hasConceptScore W2094329342C126322002 @default.
- W2094329342 hasConceptScore W2094329342C163415756 @default.
- W2094329342 hasConceptScore W2094329342C164705383 @default.
- W2094329342 hasConceptScore W2094329342C178790620 @default.
- W2094329342 hasConceptScore W2094329342C185592680 @default.
- W2094329342 hasConceptScore W2094329342C26635844 @default.
- W2094329342 hasConceptScore W2094329342C39078644 @default.
- W2094329342 hasConceptScore W2094329342C39133596 @default.
- W2094329342 hasConceptScore W2094329342C540031477 @default.
- W2094329342 hasConceptScore W2094329342C57900726 @default.
- W2094329342 hasConceptScore W2094329342C71924100 @default.
- W2094329342 hasConceptScore W2094329342C84393581 @default.
- W2094329342 hasIssue "7" @default.
- W2094329342 hasLocation W20943293421 @default.
- W2094329342 hasLocation W20943293422 @default.
- W2094329342 hasOpenAccess W2094329342 @default.
- W2094329342 hasPrimaryLocation W20943293421 @default.
- W2094329342 hasRelatedWork W2003762691 @default.
- W2094329342 hasRelatedWork W2016818225 @default.
- W2094329342 hasRelatedWork W2079871045 @default.
- W2094329342 hasRelatedWork W2081706813 @default.
- W2094329342 hasRelatedWork W2088651346 @default.
- W2094329342 hasRelatedWork W2090128822 @default.
- W2094329342 hasRelatedWork W2415499762 @default.
- W2094329342 hasRelatedWork W2495173672 @default.
- W2094329342 hasRelatedWork W299801359 @default.
- W2094329342 hasRelatedWork W3043028179 @default.
- W2094329342 hasVolume "56" @default.
- W2094329342 isParatext "false" @default.
- W2094329342 isRetracted "false" @default.
- W2094329342 magId "2094329342" @default.
- W2094329342 workType "article" @default.