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• W2094337804 abstract "The neuropathologic basis of white matter hyperintensity (WMH) volume accumulation observed on brain magnetic resonance imaging (MRI) is not known. Few studies have examined the neuropathologic correlates of cross-sectional WMH volumes and longitudinal WMH trajectories. Sixty-six elderly participants in the Oregon Brain Aging Study were included for having an autopsy, >1 MRI scan and the last MRI scan within 24 months of death. First, multiple regression analyses, adjusted for age at MRI and duration between MRI and death, were used to examine the association between cross-sectional WMH volume obtained on the MRI most proximal to death, and several neuropathologic measures including: myelin pallor, arteriosclerosis, microvascular disease, small vessel infarcts, large vessel infarcts, atherosclerosis, neurofibrillary tangle (NFT) and neuritic plaque (NP) scores. Second, a mixed-effects model was used to examine the association between longitudinal trajectory of WMH accumulation over time and neuropathologic measures. Time interaction terms for scores of myelin pallor, arteriosclerosis, microvascular disease, small vessel infarcts, large vessel infarcts, and atherosclerosis, NFT and NP scores, and APOE-ε4 presence were included. Analysis was adjusted for duration of follow up and age at death. Mean age at death was 94.54 (SD 5.45) years. Higher burdens of arteriosclerosis (P = 0.0002), microvascular disease (0.006) and small vessel infarcts (0.01) were significantly associated with larger cross-sectional WMH volume. No significant associations were observed with other pathologic measures. In the mixed-effects model, higher burdens of arteriosclerosis (P = 0.002) and NFT pathology (P = 0.02) showed more WMH accumulation over time. These findings suggest that WMH burden observed on MRI scans in very old individuals reflects the degree of small vessel ischemic disease burden, which is best captured by measures of arteriosclerosis on autopsy. Additionally, tau pathology may play a role in the processes leading to accumulation of WMH volume." @default.
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• W2094337804 date "2012-07-01" @default.
• W2094337804 modified "2023-09-27" @default.
• W2094337804 title "O4-02-05: Neuropathologic basis of white matter hyperintensity accumulation" @default.
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• W2094337804 doi "https://doi.org/10.1016/j.jalz.2012.05.1644" @default.
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