FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094339487> ?p ?o ?g. }

• W2094339487 abstract "Two juxtaglomerular cell tumors (JGCTs) were investigated in comparison with 14 endocrine tumors of the pancreas (ETPs), focusing on the cell cycle, apoptosis, and cytogenetic changes. JGCTs revealed nuclear accumulation of Cyclin D(1), together with the cyclin-dependent kinase inhibitors p21(Cip1/Waf1) and p27(Kip1). In contrast, no accumulation of Cyclin D(3), p53, p16(INK4a), or Mdm-2 was seen. Bcl-2 protein was intensively, but Rb only moderately, expressed. This immunoreactive profile was not found in the ETPs, which were negative for Bcl-2, p27(Kip1), p21(Cip1/Waf1), and - with one exception - for Cyclin D(1) (1/14) but expressed Cyclin D(3) in 7/14 cases. JGCTs displayed characteristic genetic alterations with combined losses of chromosomes 9, 11, 15, and 21 and gains of chromosome 18. In contrast, no characteristic pattern of genetic alterations was found in ETPs. In both, the amount of chromosomal aberrations correlated with tumor size. In small ETPs and JGCTs, genetic losses dominated over gains of chromosomes, whereas in large/malignant ETPs, gains and losses were equally affected. Thus, JGCTs represent a special type of renal endocrine neoplasm characterized by deregulation of cell cycle components and a typical profile of chromosomal aberrations. Since only two JCTs were investigated, further studies for validation of these results are, however, necessary." @default.
• W2094339487 created "2016-06-24" @default.
• W2094339487 creator A5038155194 @default.
• W2094339487 creator A5043709743 @default.
• W2094339487 creator A5066663298 @default.
• W2094339487 creator A5074086478 @default.
• W2094339487 creator A5081378283 @default.
• W2094339487 date "2011-06-01" @default.
• W2094339487 modified "2023-10-01" @default.
• W2094339487 title "Dysregulation of the cell cycle and chromosomal imbalances in juxtaglomerular cell tumors – A comparative study with endocrine tumors of the pancreas" @default.
• W2094339487 cites W128711618 @default.
• W2094339487 cites W1509901905 @default.
• W2094339487 cites W1569698611 @default.
• W2094339487 cites W1844339134 @default.
• W2094339487 cites W1859306058 @default.
• W2094339487 cites W189730975 @default.
• W2094339487 cites W1963660050 @default.
• W2094339487 cites W1980063720 @default.
• W2094339487 cites W1980123375 @default.
• W2094339487 cites W1980720313 @default.
• W2094339487 cites W1981908755 @default.
• W2094339487 cites W1984223780 @default.
• W2094339487 cites W1992030598 @default.
• W2094339487 cites W1992465910 @default.
• W2094339487 cites W1997068466 @default.
• W2094339487 cites W1997293262 @default.
• W2094339487 cites W1999330214 @default.
• W2094339487 cites W2007948591 @default.
• W2094339487 cites W2011135749 @default.
• W2094339487 cites W2018331062 @default.
• W2094339487 cites W2022447670 @default.
• W2094339487 cites W2025930851 @default.
• W2094339487 cites W2030476652 @default.
• W2094339487 cites W2034240230 @default.
• W2094339487 cites W2035111136 @default.
• W2094339487 cites W2035320598 @default.
• W2094339487 cites W2041573061 @default.
• W2094339487 cites W2045898536 @default.
• W2094339487 cites W2052053645 @default.
• W2094339487 cites W2053299611 @default.
• W2094339487 cites W2053471352 @default.
• W2094339487 cites W2054598880 @default.
• W2094339487 cites W2058608998 @default.
• W2094339487 cites W2062809291 @default.
• W2094339487 cites W2067028787 @default.
• W2094339487 cites W2069501397 @default.
• W2094339487 cites W2070061120 @default.
• W2094339487 cites W2075444863 @default.
• W2094339487 cites W2076409816 @default.
• W2094339487 cites W2083122376 @default.
• W2094339487 cites W2084287056 @default.
• W2094339487 cites W2089522788 @default.
• W2094339487 cites W2092104789 @default.
• W2094339487 cites W2099245258 @default.
• W2094339487 cites W2102942479 @default.
• W2094339487 cites W2137124052 @default.
• W2094339487 cites W2142826725 @default.
• W2094339487 cites W2154546296 @default.
• W2094339487 cites W2162846788 @default.
• W2094339487 cites W2337481134 @default.
• W2094339487 cites W2391575159 @default.
• W2094339487 cites W2396213387 @default.
• W2094339487 cites W2414407772 @default.
• W2094339487 cites W2472147509 @default.
• W2094339487 cites W78569304 @default.
• W2094339487 cites W2409613836 @default.
• W2094339487 doi "https://doi.org/10.1016/j.prp.2011.02.009" @default.
• W2094339487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21482036" @default.
• W2094339487 hasPublicationYear "2011" @default.
• W2094339487 type Work @default.
• W2094339487 sameAs 2094339487 @default.
• W2094339487 citedByCount "3" @default.
• W2094339487 countsByYear W20943394872012 @default.
• W2094339487 countsByYear W20943394872017 @default.
• W2094339487 countsByYear W20943394872021 @default.
• W2094339487 crossrefType "journal-article" @default.
• W2094339487 hasAuthorship W2094339487A5038155194 @default.
• W2094339487 hasAuthorship W2094339487A5043709743 @default.
• W2094339487 hasAuthorship W2094339487A5066663298 @default.
• W2094339487 hasAuthorship W2094339487A5074086478 @default.
• W2094339487 hasAuthorship W2094339487A5081378283 @default.
• W2094339487 hasConcept C104317684 @default.
• W2094339487 hasConcept C120089663 @default.
• W2094339487 hasConcept C126322002 @default.
• W2094339487 hasConcept C134018914 @default.
• W2094339487 hasConcept C1491633281 @default.
• W2094339487 hasConcept C199835354 @default.
• W2094339487 hasConcept C2778764654 @default.
• W2094339487 hasConcept C29537977 @default.
• W2094339487 hasConcept C30481170 @default.
• W2094339487 hasConcept C46699223 @default.
• W2094339487 hasConcept C502942594 @default.
• W2094339487 hasConcept C54355233 @default.
• W2094339487 hasConcept C71315377 @default.
• W2094339487 hasConcept C71924100 @default.
• W2094339487 hasConcept C86803240 @default.
• W2094339487 hasConcept C9743823 @default.
• W2094339487 hasConceptScore W2094339487C104317684 @default.
• W2094339487 hasConceptScore W2094339487C120089663 @default.
• W2094339487 hasConceptScore W2094339487C126322002 @default.

• next