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• W2094340322 abstract "Animals with neonatal ventral hippocampal lesions develop during or after adolescence abnormal behaviors related to schizophrenia such as anxiety and latent inhibition disruption. The aim of this study was to test whether haloperidol injection prior to pre-exposure session in the latent inhibition test would facilitate latent inhibition. Lesioned animals showed a significant decrease in the number and duration of social interactions, a decrease in the marbles buried, a significant increase in locomotor activity, and a disruption of latent inhibition. In the conditioned taste aversion test, injection of haloperidol produced the recovery of latent inhibition. These findings demonstrate that neonatal lidocaine lesion of the ventral hippocampus can induce behavioral changes related to schizophrenia, and injection of haloperidol, when restricted only to a three-day pre-exposure, is sufficient to facilitate latent inhibition. Les lésions néonatales de l’hippocampe ventral chez les rats provoquent des altérations comportementales, comme l’anxiété et la diminution de l’inhibition latente, deux comportements relatifs au phénotype schizophrène. Notre travail avait pour objectif de préciser l’effet facilitateur de l’halopéridol sur l’inhibition latente après son administration en phase de préexposition à la suite d’une lésion néonatale bilatérale de l’hippocampe ventral. Nos résultats montrent que les animaux lésés présentent une diminution significative aussi bien au niveau du nombre de leurs interactions sociales qu’à celui du nombre de billes enterrées. Chez ces animaux, l’activité locomotrice est largement augmentée par rapport aux témoins. Le conditionnement d’évitement a montré que la lésion altère de façon significative l’inhibition latente, qui se trouve diminuée par rapport au témoin. Ce résultat est confirmé par le test d’aversion gustative conditionnée. Cependant, nous avons pu montrer que l’administration d’halopéridol avant chaque session de pré-exposition permet de faciliter l’inhibition latente." @default.
• W2094340322 created "2016-06-24" @default.
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• W2094340322 date "2014-10-01" @default.
• W2094340322 modified "2023-10-18" @default.
• W2094340322 title "Haloperidol treatment at pre-exposure phase reduces the disturbance of latent inhibition in rats with neonatal ventral hippocampus lesions" @default.
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• W2094340322 doi "https://doi.org/10.1016/j.crvi.2014.07.005" @default.
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