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- W2094342837 endingPage "906" @default.
- W2094342837 startingPage "895" @default.
- W2094342837 abstract "To compete in nature against other forms of life, microorganisms possess regulatory mechanisms which control production of their metabolites, thus, protecting against overproduction and excretion of these primary and secondary metabolites into the environment. To effect such an economical form of life, they possess regulatory mechanisms which control production of these metabolites and protect against overproduction and excretion into the environment of excess concentrations. In the field of industrial fermentation, the opposite concept prevails. Fermentation microbiologists search for a rare overproducing strain in nature, then further deregulate the microorganism so that it overproduces huge quantities of a desired commercially important product such as a metabolite or an enzyme. Deregulation is brought about by nutritional as well as classical and molecular genetic manipulations to bypass and/or remove negative regulatory mechanisms and to enhance positive regulatory mechanisms. These mechanisms include induction, nutritional regulation by sources of carbon, nitrogen and phosphorus, and feedback control. The controls and their modification by biotechnologists are the subjects of this review." @default.
- W2094342837 created "2016-06-24" @default.
- W2094342837 creator A5023185322 @default.
- W2094342837 creator A5081298367 @default.
- W2094342837 date "2002-12-01" @default.
- W2094342837 modified "2023-10-01" @default.
- W2094342837 title "Metabolic regulation of fermentation processes" @default.
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