Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094347756> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2094347756 endingPage "226" @default.
- W2094347756 startingPage "219" @default.
- W2094347756 abstract "To define the mode of the vasorelaxing action of nicorandil as compared to nitroglycerin, the effects of the agent on the contractile response to various stimulations in rabbit aorta, cat coronary arteries and rabbit basilar arteries were evaluated. Nicorandil had a greater relaxing effect on the maximum response to norepinephrine (NE) than on the potassium (K+) response on all vascular smooth muscles used. In coronary and basilar arteries, however, the inhibitory action of nitroglycerin was not different on the response to both agonists. In coronary and basilar arteries the maximum inhibition of the NE response by nicorandil was greater than that by nitroglycerin. Nicorandil (10(-5) M) but not phentolamine (10(-5) M) inhibited the PGF2 alpha-induced contraction of the aorta. Either nicorandil or nitroglycerin suppressed the response of the aorta to the transmural stimulation. In a Ca2+-free medium containing K+ (40 mM), nicorandil decreased the response to excess Ca2+ in all preparations whereas, nifedipine (10(-6)-10(-5) M) abolished it. Nitroglycerin, however, had no effect on the Ca2+-induced contraction on basilar arteries. In a Ca2+-free medium, the residual NE-induced contraction was inhibited by nicorandil or nitroglycerin but not by nifedipine . The combined treatment with nicorandil and nitroglycerin caused a stronger suppression of residual NE response that that of a single treatment with either agent suggesting the different site of action for the two agents. These results suggest that the mode of vasorelaxing action of nicorandil may be due to the alteration (inhibition) of Ca2+ kinetics in the cell." @default.
- W2094347756 created "2016-06-24" @default.
- W2094347756 creator A5005970624 @default.
- W2094347756 creator A5017614330 @default.
- W2094347756 creator A5062723993 @default.
- W2094347756 creator A5073295534 @default.
- W2094347756 creator A5081014539 @default.
- W2094347756 date "1984-03-01" @default.
- W2094347756 modified "2023-10-17" @default.
- W2094347756 title "Relaxing effect of nicorandil (N-2-(hydroxyethyl)-nicotinamide nitrate), a new anti-angina agent, on the isolated vascular smooth muscle" @default.
- W2094347756 cites W1917840520 @default.
- W2094347756 cites W1961259257 @default.
- W2094347756 cites W1964567675 @default.
- W2094347756 cites W1967780571 @default.
- W2094347756 cites W1980474788 @default.
- W2094347756 cites W1998439339 @default.
- W2094347756 cites W2031922312 @default.
- W2094347756 cites W2038252466 @default.
- W2094347756 cites W2045187633 @default.
- W2094347756 cites W2057870784 @default.
- W2094347756 cites W2306217173 @default.
- W2094347756 cites W2403108297 @default.
- W2094347756 doi "https://doi.org/10.1016/0014-2999(84)90244-9" @default.
- W2094347756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6234181" @default.
- W2094347756 hasPublicationYear "1984" @default.
- W2094347756 type Work @default.
- W2094347756 sameAs 2094347756 @default.
- W2094347756 citedByCount "18" @default.
- W2094347756 crossrefType "journal-article" @default.
- W2094347756 hasAuthorship W2094347756A5005970624 @default.
- W2094347756 hasAuthorship W2094347756A5017614330 @default.
- W2094347756 hasAuthorship W2094347756A5062723993 @default.
- W2094347756 hasAuthorship W2094347756A5073295534 @default.
- W2094347756 hasAuthorship W2094347756A5081014539 @default.
- W2094347756 hasConcept C126322002 @default.
- W2094347756 hasConcept C163415756 @default.
- W2094347756 hasConcept C185592680 @default.
- W2094347756 hasConcept C24998067 @default.
- W2094347756 hasConcept C2776820930 @default.
- W2094347756 hasConcept C2778742706 @default.
- W2094347756 hasConcept C2778902376 @default.
- W2094347756 hasConcept C2779066535 @default.
- W2094347756 hasConcept C2779395532 @default.
- W2094347756 hasConcept C2779980429 @default.
- W2094347756 hasConcept C2780253649 @default.
- W2094347756 hasConcept C2781012200 @default.
- W2094347756 hasConcept C2992686903 @default.
- W2094347756 hasConcept C42219234 @default.
- W2094347756 hasConcept C519063684 @default.
- W2094347756 hasConcept C71924100 @default.
- W2094347756 hasConceptScore W2094347756C126322002 @default.
- W2094347756 hasConceptScore W2094347756C163415756 @default.
- W2094347756 hasConceptScore W2094347756C185592680 @default.
- W2094347756 hasConceptScore W2094347756C24998067 @default.
- W2094347756 hasConceptScore W2094347756C2776820930 @default.
- W2094347756 hasConceptScore W2094347756C2778742706 @default.
- W2094347756 hasConceptScore W2094347756C2778902376 @default.
- W2094347756 hasConceptScore W2094347756C2779066535 @default.
- W2094347756 hasConceptScore W2094347756C2779395532 @default.
- W2094347756 hasConceptScore W2094347756C2779980429 @default.
- W2094347756 hasConceptScore W2094347756C2780253649 @default.
- W2094347756 hasConceptScore W2094347756C2781012200 @default.
- W2094347756 hasConceptScore W2094347756C2992686903 @default.
- W2094347756 hasConceptScore W2094347756C42219234 @default.
- W2094347756 hasConceptScore W2094347756C519063684 @default.
- W2094347756 hasConceptScore W2094347756C71924100 @default.
- W2094347756 hasIssue "2-3" @default.
- W2094347756 hasLocation W20943477561 @default.
- W2094347756 hasLocation W20943477562 @default.
- W2094347756 hasOpenAccess W2094347756 @default.
- W2094347756 hasPrimaryLocation W20943477561 @default.
- W2094347756 hasRelatedWork W1978874226 @default.
- W2094347756 hasRelatedWork W1992244118 @default.
- W2094347756 hasRelatedWork W1996382392 @default.
- W2094347756 hasRelatedWork W2011861633 @default.
- W2094347756 hasRelatedWork W2015161697 @default.
- W2094347756 hasRelatedWork W2030925206 @default.
- W2094347756 hasRelatedWork W2089068807 @default.
- W2094347756 hasRelatedWork W2094347756 @default.
- W2094347756 hasRelatedWork W2366901417 @default.
- W2094347756 hasRelatedWork W2404937739 @default.
- W2094347756 hasVolume "99" @default.
- W2094347756 isParatext "false" @default.
- W2094347756 isRetracted "false" @default.
- W2094347756 magId "2094347756" @default.
- W2094347756 workType "article" @default.