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• W2094354503 startingPage "227" @default.
• W2094354503 abstract "The evolution of the genetic code is mapped out starting with the aminoacyl tRNA-synthetases and their interaction with the operational code in the tRNA acceptor arm. Combining this operational code with a metric based on the biosynthesis of amino acids from the Citric acid, we come to the conclusion that the earliest genetic code was a Guanine Cytosine (GC) code. This has implications for the likely earliest positively charged amino acids. The progression from this pure GC code to the extant one is traced out in the evolution of the Large Ribosomal Subunit, LSU, and its proteins; in particular those associated with the Peptidyl Transfer Center (PTC) and the nascent peptide exit tunnel. This progression has implications for the earliest encoded peptides and their evolutionary progression into full complex proteins." @default.
• W2094354503 created "2016-06-24" @default.
• W2094354503 creator A5058107013 @default.
• W2094354503 creator A5091890945 @default.
• W2094354503 date "2014-05-20" @default.
• W2094354503 modified "2023-10-06" @default.
• W2094354503 title "The Evolution of the Ribosome and the Genetic Code" @default.
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• W2094354503 doi "https://doi.org/10.3390/life4020227" @default.
• W2094354503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4187167" @default.
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• W2094354503 hasPublicationYear "2014" @default.
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