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• W2094362604 abstract "We have previously shown that persistent α-synuclein overexpression in ventral midbrain of marmoset leads to a distinctive neurodegenerative process and motor defects. The neurodegeneration was confined to caudate putamen dopaminergic fibers in animals overexpressing wild-type (wt) α-synuclein. However, A53T α-synuclein overexpression induced neurodegeneration that resulted in nigral dopaminergic cell death. Here, we analyze the microglia population in the midbrain of these animals by stereological quantification of Iba1+ cells. Our data here show that monkeys overexpressing A53T α-synuclein showed a long-term increase in microglia presenting macrophagic morphology. However, wt α-synuclein overexpression, despite the absence of dopaminergic cell death, resulted in a permanent robust increase of the microglia population characterized by a range of distinct morphological types that persisted after 1 year. These results confirm that the microglial response differs depending on the type of α-synuclein (wt/A53T) and/or whether α-synuclein expression results in cell death or not, suggesting that microglia may play different roles during disease progression. Furthermore, the microglial response is modulated by events related to α-synuclein expression in substantia nigra and persists in the long term. The data presented here is in agreement with that previously observed in a recombinant adeno-associated virus (rAAV) α-synuclein rat model, thereby validating both the findings and the model, and highlighting the translational potential of the rodent model to higher species closer to humans." @default.
• W2094362604 created "2016-06-24" @default.
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• W2094362604 creator A5019698136 @default.
• W2094362604 creator A5081650277 @default.
• W2094362604 creator A5083016310 @default.
• W2094362604 date "2012-04-01" @default.
• W2094362604 modified "2023-09-27" @default.
• W2094362604 title "Long-term polarization of microglia upon α-synuclein overexpression in nonhuman primates" @default.
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• W2094362604 doi "https://doi.org/10.1016/j.neuroscience.2012.02.004" @default.
• W2094362604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22342967" @default.
• W2094362604 hasPublicationYear "2012" @default.
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